IRAK2 — 102 ClinVar variants

All ClinVar germline IRAK2 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 85 flagged for review →

1 Benign · 9 Likely benign · 92 Uncertain significance

Full IRAK2 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions

⚑ Evidence disagreements 85

Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.

Predictors lean, ClinVar uncertain 70

ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.

Predictors split 15

The independent predictors disagree with each other — read with care.

All IRAK2 variants

Benign 1

p.Leu392Val Multiple submitters

Likely benign 9

c.-2C>T Single submitter
p.Ala87= Single submitter
p.Asp168Asn Single submitter
p.Asp202= Single submitter
p.Glu472Lys Single submitter
p.Gly328Ser Single submitter
p.Met369Val Single submitter
p.Thr508Met Single submitter
p.Val336Ile Single submitter

Uncertain significance 92

p.Ala152Thr Single submitter ⚠
p.Ala192Thr Single submitter ⚠
p.Ala451Ser Single submitter ⚠
p.Ala477Thr Single submitter ⚠
p.Ala573Ser Single submitter ⚠
p.Ala601Val Single submitter ⚠
p.Arg312His Single submitter
p.Arg388Trp Single submitter
p.Arg395Gln Single submitter ⚠
p.Arg485Cys Single submitter ⚠
p.Arg485Pro Single submitter
p.Arg502Trp Single submitter ⚠
p.Arg50Gln Single submitter ⚠
p.Arg58Gln Single submitter ⚠
p.Arg58Trp Single submitter ⚠
p.Arg67Gly Single submitter ⚠
p.Arg80Cys Single submitter ⚠
p.Asn211His Single submitter ⚠
p.Asn268Ile Single submitter ⚠
p.Asn268Ser Single submitter ⚠
p.Asn524Lys Single submitter ⚠
p.Asp108Asn Single submitter ⚠
p.Asp202Val Single submitter ⚠
p.Cys261Arg Single submitter
p.Cys79Ser Single submitter ⚠
p.Gln150Arg Single submitter ⚠
p.Glu124Lys Single submitter ⚠
p.Glu251Lys Single submitter ⚠
p.Glu324Lys Single submitter ⚠
p.Glu447Lys Single submitter ⚠
p.Glu453Asp Single submitter ⚠
p.Glu517Lys Single submitter ⚠
p.Gly130Arg Single submitter ⚠
p.Gly219Glu Single submitter ⚠
p.Gly227Val Single submitter ⚠
p.Gly462Ser Single submitter ⚠
p.Gly464Arg Single submitter ⚠
p.Gly518Asp Single submitter ⚠
p.Gly582Cys Single submitter ⚠
p.His266Tyr Single submitter ⚠
p.Ile315Leu Single submitter ⚠
p.Ile332Phe Single submitter ⚠
p.Ile596Ser Single submitter ⚠
p.Ile5Val Single submitter ⚠
p.Ile90Thr Single submitter ⚠
p.Leu342Phe Single submitter ⚠
p.Leu428Phe Single submitter ⚠
p.Leu537Phe Single submitter ⚠
p.Leu74Pro Single submitter ⚠
p.Leu78Pro Single submitter ⚠
p.Leu83Phe Single submitter
p.Lys238Arg Single submitter ⚠
p.Lys44Asn Single submitter ⚠
p.Lys452Thr Single submitter ⚠
p.Lys602Glu Single submitter ⚠
p.Met289Thr Single submitter
p.Met543Leu Single submitter ⚠
p.Pro104Arg Single submitter ⚠
p.Pro139Leu Single submitter ⚠
p.Pro151Leu Single submitter ⚠
p.Pro306Ala Single submitter ⚠
p.Pro306Arg Single submitter ⚠
p.Pro306Ser Single submitter ⚠
p.Pro349Ser Single submitter ⚠
p.Pro360Ala Single submitter ⚠
p.Pro413Arg Single submitter ⚠
p.Pro433Ser Single submitter ⚠
p.Pro95Leu Single submitter ⚠
p.Ser10Cys Single submitter ⚠
p.Ser199Asn Single submitter ⚠
p.Ser217Arg Single submitter ⚠
p.Ser304Leu Single submitter ⚠
p.Ser33Phe Single submitter ⚠
p.Ser420Asn Single submitter ⚠
p.Ser434Thr Single submitter ⚠
p.Ser516Cys Single submitter ⚠
p.Ser521Phe Single submitter ⚠
p.Ser522Phe Single submitter ⚠
p.Ser575Phe Single submitter ⚠
p.Thr242Arg Single submitter ⚠
p.Thr377Met Single submitter ⚠
p.Thr410Met Single submitter ⚠
p.Thr508Ser Single submitter ⚠
p.Trp63Ser Single submitter
p.Tyr381His Single submitter ⚠
p.Tyr423Phe Single submitter ⚠
p.Tyr4Cys Single submitter ⚠
p.Tyr6Cys Single submitter ⚠
p.Val120Ile Single submitter ⚠
p.Val269Phe Single submitter ⚠
p.Val35Leu Single submitter ⚠
p.Val532Ile Single submitter ⚠