IRF3 — 96 ClinVar variants
All ClinVar germline IRF3 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 63 flagged for review →
3 Conflicting · 6 Benign · 2 Benign/Likely benign · 23 Likely benign · 62 Uncertain significance
Full IRF3 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 63
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors agree, ClinVar conflicts 2
ClinVar submitters conflict, but the independent predictors unanimously agree — a QC review flag, not a reclassification.
-
IRF3 p.Ala277Thr
Conflicting
Single submitter
herpes simplex encephalitis, susceptibility to, 7
- IRF3 p.Asn178Ser Conflicting Single submitter
Predictors lean, ClinVar uncertain 28
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
-
IRF3 p.Arg213Cys
Uncertain significance
Multiple submitters
herpes simplex encephalitis, susceptibility to, 7
- IRF3 p.Asn28Lys Uncertain significance Multiple submitters
- IRF3 p.Gln15Arg Uncertain significance Multiple submitters
- IRF3 p.Ser97Arg Uncertain significance Multiple submitters
- IRF3 p.Ala163Ser Uncertain significance Single submitter
- IRF3 p.Arg236Ser Uncertain significance Single submitter
- IRF3 p.Asp102Asn Uncertain significance Single submitter
- IRF3 p.Asp355Asn Uncertain significance Single submitter
- IRF3 p.Gln20Glu Uncertain significance Single submitter
- IRF3 p.Gln354His Uncertain significance Single submitter
-
IRF3 p.Glu417Asp
Uncertain significance
Single submitter
developmental and epileptic encephalopathy, 26
- IRF3 p.Glu426Lys Uncertain significance Single submitter
- IRF3 p.Gly304Arg Uncertain significance Single submitter
- IRF3 p.His305Gln Uncertain significance Single submitter
- IRF3 p.Ile220Thr Uncertain significance Single submitter
- IRF3 p.Leu176Ser Uncertain significance Single submitter
- IRF3 p.Leu401Val Uncertain significance Single submitter
- IRF3 p.Met250Thr Uncertain significance Single submitter
- IRF3 p.Pro151Ser Uncertain significance Single submitter
- IRF3 p.Pro153Ala Uncertain significance Single submitter
- IRF3 p.Pro181Leu Uncertain significance Single submitter
- IRF3 p.Pro198Leu Uncertain significance Single submitter
- IRF3 p.Pro198Ser Uncertain significance Single submitter
- IRF3 p.Pro324Leu Uncertain significance Single submitter
- IRF3 p.Ser398Arg Uncertain significance Single submitter
- IRF3 p.Thr132Ile Uncertain significance Single submitter
- IRF3 p.Thr132Ser Uncertain significance Single submitter
- IRF3 p.Trp241Cys Uncertain significance Single submitter
Predictors split 33
The independent predictors disagree with each other — read with care.
- IRF3 p.Arg96Gln Benign Multiple submitters
- IRF3 p.Arg96Trp Uncertain significance Multiple submitters
-
IRF3 p.Leu344Phe
Uncertain significance
Multiple submitters
herpes simplex encephalitis, susceptibility to, 7
- IRF3 p.Ala379Thr Uncertain significance Single submitter
- IRF3 p.Arg31Gly Uncertain significance Single submitter
- IRF3 p.Arg341Cys Uncertain significance Single submitter
- IRF3 p.Arg86Cys Uncertain significance Single submitter
- IRF3 p.Arg86His Uncertain significance Single submitter
- IRF3 p.Asn146Lys Uncertain significance Single submitter
- IRF3 p.Asp321Glu Uncertain significance Single submitter
- IRF3 p.Asp45Asn Uncertain significance Single submitter
- IRF3 p.Glu189Lys Uncertain significance Single submitter
- IRF3 p.Glu232Lys Uncertain significance Single submitter
- IRF3 p.Gly199Ala Uncertain significance Single submitter
- IRF3 p.Gly19Glu Uncertain significance Single submitter
- IRF3 p.Gly335Glu Uncertain significance Single submitter
-
IRF3 p.Gly337Arg
Uncertain significance
Single submitter
herpes simplex encephalitis, susceptibility to, 7
- IRF3 p.Gly382Glu Likely benign Single submitter
- IRF3 p.His394Arg Likely benign Single submitter
- IRF3 p.Ile220Ser Uncertain significance Single submitter
- IRF3 p.Leu18Met Uncertain significance Single submitter
-
IRF3 p.Leu21Pro
Uncertain significance
Single submitter
herpes simplex encephalitis, susceptibility to, 7
- IRF3 p.Leu322Pro Uncertain significance Single submitter
- IRF3 p.Lys315Asn Uncertain significance Single submitter
- IRF3 p.Pro223Leu Uncertain significance Single submitter
- IRF3 p.Ser339Leu Likely benign Single submitter
- IRF3 p.Thr291Ile Uncertain significance Single submitter
- IRF3 p.Tyr342Cys Likely benign Single submitter
- IRF3 p.Val261Met Uncertain significance Single submitter
- IRF3 p.Val319Met Uncertain significance Single submitter
- IRF3 p.Val363Leu Uncertain significance Single submitter
- IRF3 p.Val363Met Benign Single submitter
-
IRF3 p.Arg276Gln
Likely benign
No assertion criteria
IRF3-related disorder
All IRF3 variants
Conflicting classifications of pathogenicity 3
- p.Ala277Thr Single submitter herpes simplex encephalitis, susceptibility to, 7 ⚠
- p.Ala379= Single submitter
- p.Asn178Ser Single submitter ⚠
Benign 6
- p.Arg96Gln Multiple submitters ⚠
- p.Ser427Thr Multiple submitters
- c.166-24A>G Single submitter
- p.Val363Met Single submitter ⚠
- p.Leu403= No assertion criteria IRF3-related disorder
- p.Ser175Gly No assertion criteria IRF3-related disorder
Benign/Likely benign 2
Likely benign 23
- c.602-12_602-4del Single submitter
- p.Ala163= Single submitter
- p.Arg380Gln Single submitter
- p.Arg7= Single submitter
- p.Glu88Asp Single submitter
- p.Gly382Glu Single submitter ⚠
- p.His394Arg Single submitter ⚠
- p.Ile106Val Single submitter
- p.Leu415= Single submitter
- p.Pro198= Single submitter
- p.Ser296= Single submitter
- p.Ser339Leu Single submitter ⚠
- p.Thr126= Single submitter
- p.Thr331Ala Single submitter
- p.Thr333= Single submitter
- p.Thr333Met Single submitter
- p.Tyr342Cys Single submitter ⚠
- p.Arg276Gln No assertion criteria IRF3-related disorder ⚠
- p.Asn127Ser No assertion criteria IRF3-related disorder
- p.Gly278= No assertion criteria IRF3-related disorder
- p.Pro223= No assertion criteria IRF3-related disorder
- p.Ser405= No assertion criteria IRF3-related disorder
- p.Val295= No assertion criteria IRF3-related disorder
Uncertain significance 62
- p.Arg213Cys Multiple submitters herpes simplex encephalitis, susceptibility to, 7 ⚠
- p.Arg96Trp Multiple submitters ⚠
- p.Asn28Lys Multiple submitters ⚠
- p.Gln15Arg Multiple submitters ⚠
- p.Leu344Phe Multiple submitters herpes simplex encephalitis, susceptibility to, 7 ⚠
- p.Ser97Arg Multiple submitters ⚠
- c.983-10G>T Single submitter
- c.*30C>G Single submitter
- c.*36G>A Single submitter
- p.Ala163Ser Single submitter ⚠
- p.Ala379Thr Single submitter ⚠
- p.Arg236Ser Single submitter ⚠
- p.Arg31Gly Single submitter ⚠
- p.Arg341Cys Single submitter ⚠
- p.Arg86Cys Single submitter ⚠
- p.Arg86His Single submitter ⚠
- p.Asn146Lys Single submitter ⚠
- p.Asp102Asn Single submitter ⚠
- p.Asp321Glu Single submitter ⚠
- p.Asp355Asn Single submitter ⚠
- p.Asp45Asn Single submitter ⚠
- p.Gln20Glu Single submitter ⚠
- p.Gln354His Single submitter ⚠
- p.Gln356Ter Single submitter IRF3-related disorder
- p.Gln422= Single submitter
- p.Glu189Lys Single submitter ⚠
- p.Glu232Lys Single submitter ⚠
- p.Glu417= Single submitter
- p.Glu417Asp Single submitter developmental and epileptic encephalopathy, 26 ⚠
- p.Glu426Lys Single submitter ⚠
- p.Gly115= Single submitter
- p.Gly199Ala Single submitter ⚠
- p.Gly19Glu Single submitter ⚠
- p.Gly304Arg Single submitter ⚠
- p.Gly335Glu Single submitter ⚠
- p.Gly337Arg Single submitter herpes simplex encephalitis, susceptibility to, 7 ⚠
- p.Gly383= Single submitter
- p.His305Gln Single submitter ⚠
- p.Ile220Ser Single submitter ⚠
- p.Ile220Thr Single submitter ⚠
- p.Leu176Ser Single submitter ⚠
- p.Leu18Met Single submitter ⚠
- p.Leu21Pro Single submitter herpes simplex encephalitis, susceptibility to, 7 ⚠
- p.Leu322Pro Single submitter ⚠
- p.Leu401Val Single submitter ⚠
- p.Lys315Asn Single submitter ⚠
- p.Met250Thr Single submitter ⚠
- p.Pro151Ser Single submitter ⚠
- p.Pro153Ala Single submitter ⚠
- p.Pro181Leu Single submitter ⚠
- p.Pro198Leu Single submitter ⚠
- p.Pro198Ser Single submitter ⚠
- p.Pro223Leu Single submitter ⚠
- p.Pro324Leu Single submitter ⚠
- p.Ser398Arg Single submitter ⚠
- p.Thr132Ile Single submitter ⚠
- p.Thr132Ser Single submitter ⚠
- p.Thr291Ile Single submitter ⚠
- p.Trp241Cys Single submitter ⚠
- p.Val261Met Single submitter ⚠
- p.Val319Met Single submitter ⚠
- p.Val363Leu Single submitter ⚠