Sugi Variant

Sugi Variant/IRS1

IRS1 — 222 ClinVar variants

All ClinVar germline IRS1 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 167 flagged for review →

2 Pathogenic · 2 Conflicting · 8 Benign · 8 Benign/Likely benign · 35 Likely benign · 167 Uncertain significance

Full IRS1 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions

⚑ Evidence disagreements 167

Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.

Predictors vs ClinVar 1

ClinVar calls these pathogenic, but the computational predictors lean tolerated — the highest-value review flag.

Predictors agree, ClinVar conflicts 2

ClinVar submitters conflict, but the independent predictors unanimously agree — a QC review flag, not a reclassification.

Predictors lean, ClinVar uncertain 132

ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.

Predictors split 32

The independent predictors disagree with each other — read with care.

All IRS1 variants

Pathogenic 2

Conflicting classifications of pathogenicity 2

Benign 8

Benign/Likely benign 8

Likely benign 35

Uncertain significance 167