ITGA1 — 162 ClinVar variants

All ClinVar germline ITGA1 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 145 flagged for review →

7 Benign · 6 Likely benign · 149 Uncertain significance

Full ITGA1 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions

⚑ Evidence disagreements 145

Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.

Predictors lean, ClinVar uncertain 115

ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.

Predictors split 30

The independent predictors disagree with each other — read with care.

All ITGA1 variants

Benign 7

c.1455+7T>C Multiple submitters
p.Glu221= Multiple submitters
p.Phe737= Multiple submitters
p.Pro83= Multiple submitters
p.Ser1096= Multiple submitters
p.Ser1121Arg Multiple submitters
p.Val158Met Single submitter

Likely benign 6

p.Arg1110Gln Single submitter
p.Asp1061= Single submitter
p.Glu928= Single submitter
p.Met1047Thr Single submitter
p.Ser954= Single submitter
p.Lys81Thr No assertion criteria EBV-positive nodal T- and NK-cell lymphoma

Uncertain significance 149

p.Ala823Thr Multiple submitters ⚠
p.Asn966Ser Multiple submitters ⚠
p.Ala2Ser Single submitter ⚠
p.Ala371Val Single submitter ⚠
p.Ala395Thr Single submitter
p.Ala410Pro Single submitter ⚠
p.Ala660Thr Single submitter ⚠
p.Arg1110Trp Single submitter ⚠
p.Arg137Gly Single submitter ⚠
p.Arg24Cys Single submitter ⚠
p.Arg24His Single submitter ⚠
p.Arg266Gln Single submitter ⚠
p.Arg289Gln Single submitter ⚠
p.Arg458Gln Single submitter ⚠
p.Arg4Pro Single submitter ⚠
p.Arg553Gln Single submitter ⚠
p.Arg570His Single submitter ⚠
p.Arg614Thr Single submitter ⚠
p.Arg620His Single submitter ⚠
p.Arg665Gln Single submitter ⚠
p.Arg6Ser Single submitter ⚠
p.Arg723Cys Single submitter ⚠
p.Arg723His Single submitter ⚠
p.Arg734Gly Single submitter ⚠
p.Arg752Gln Single submitter ⚠
p.Asn1029Asp Single submitter ⚠
p.Asn1083Asp Single submitter ⚠
p.Asn181Asp Single submitter ⚠
p.Asn460Asp Single submitter
p.Asn532Ser Single submitter ⚠
p.Asn582Ser Single submitter ⚠
p.Asn587Lys Single submitter ⚠
p.Asn699Ser Single submitter ⚠
p.Asn74Tyr Single submitter ⚠
p.Asn981His Single submitter ⚠
p.Asp1037Val Single submitter ⚠
p.Asp172Gly Single submitter ⚠
p.Asp172Tyr Single submitter ⚠
p.Asp187Asn Single submitter ⚠
p.Asp367Glu Single submitter ⚠
p.Asp978Asn Single submitter ⚠
p.Cys1062Trp Single submitter ⚠
p.Cys148Ser Single submitter ⚠
p.Cys167Trp Single submitter ⚠
p.Cys297Arg Single submitter ⚠
p.Cys297Trp Single submitter ⚠
p.Cys558Tyr Single submitter ⚠
p.Cys697Arg Single submitter ⚠
p.Gln206His Single submitter ⚠
p.Glu1178Lys Single submitter ⚠
p.Glu232Asp Single submitter ⚠
p.Glu484Gln Single submitter ⚠
p.Glu543Asp Single submitter ⚠
p.Glu57Val Single submitter ⚠
p.Glu871Lys Single submitter ⚠
p.Glu967Asp Single submitter ⚠
p.Glu967Gly Single submitter ⚠
p.Gly1021Glu Single submitter ⚠
p.Gly126Arg Single submitter ⚠
p.Gly655Asp Single submitter ⚠
p.Gly809Glu Single submitter ⚠
p.Gly87Ala Single submitter ⚠
p.Gly896Glu Single submitter ⚠
p.His220Tyr Single submitter ⚠
p.His288Tyr Single submitter ⚠
p.His607Asp Single submitter ⚠
p.His860Arg Single submitter ⚠
p.Ile254Met Single submitter ⚠
p.Ile467Val Single submitter ⚠
p.Ile507Met Single submitter ⚠
p.Ile507Val Single submitter ⚠
p.Ile653Thr Single submitter ⚠
p.Ile749Phe Single submitter ⚠
p.Ile802Val Single submitter ⚠
p.Ile815Asn Single submitter ⚠
p.Ile963Val Single submitter ⚠
p.Ile979Met Single submitter ⚠
p.Ile985Val Single submitter ⚠
p.Leu1022Phe Single submitter ⚠
p.Leu1158Pro Single submitter ⚠
p.Leu1163Met Single submitter
p.Leu18Phe Single submitter ⚠
p.Leu393Phe Single submitter ⚠
p.Leu451Phe Single submitter ⚠
p.Leu643Val Single submitter ⚠
p.Leu656Phe Single submitter ⚠
p.Leu661His Single submitter ⚠
p.Leu933Pro Single submitter ⚠
p.Lys1133Glu Single submitter ⚠
p.Lys1170Gln Single submitter ⚠
p.Lys428Asn Single submitter ⚠
p.Lys631Asn Single submitter ⚠
p.Lys81Arg Single submitter ⚠
p.Lys94Asn Single submitter ⚠
p.Met276Thr Single submitter ⚠
p.Met392Ile Single submitter ⚠
p.Met514Lys Single submitter ⚠
p.Met514Thr Single submitter ⚠
p.Met997Val Single submitter ⚠
p.Phe1093Ser Single submitter ⚠
p.Phe632Cys Single submitter ⚠
p.Phe839Tyr Single submitter ⚠
p.Pro1019Ala Single submitter ⚠
p.Pro1137Gln Single submitter ⚠
p.Pro1137Leu Single submitter ⚠
p.Pro153Arg Single submitter ⚠
p.Pro42Leu Single submitter ⚠
p.Pro431Gln Single submitter ⚠
p.Pro544Ser Single submitter ⚠
p.Pro67Leu Single submitter ⚠
p.Pro795Thr Single submitter ⚠
p.Pro83Ser Single submitter ⚠
p.Pro929Thr Single submitter ⚠
p.Pro943Leu Single submitter ⚠
p.Ser1076Tyr Single submitter ⚠
p.Ser1096Leu Single submitter ⚠
p.Ser149Ala Single submitter ⚠
p.Ser332Asn Single submitter ⚠
p.Ser387Leu Single submitter ⚠
p.Ser609Ile Single submitter ⚠
p.Ser710Phe Single submitter
p.Ser793Ala Single submitter ⚠
p.Ser851Thr Single submitter ⚠
p.Ser921Arg Single submitter ⚠
p.Ser921Cys Single submitter ⚠
p.Ser955Pro Single submitter ⚠
p.Thr1010Lys Single submitter ⚠
p.Thr154Ser Single submitter ⚠
p.Thr420Ile Single submitter ⚠
p.Thr462Arg Single submitter ⚠
p.Thr548Met Single submitter ⚠
p.Thr695Ala Single submitter ⚠
p.Thr776Met Single submitter ⚠
p.Trp1164Arg Single submitter ⚠
p.Trp17Arg Single submitter ⚠
p.Trp186Ser Single submitter ⚠
p.Tyr399Ser Single submitter ⚠
p.Tyr49Cys Single submitter ⚠
p.Tyr80Cys Single submitter ⚠
p.Val176Gly Single submitter ⚠
p.Val209Ile Single submitter ⚠
p.Val218Leu Single submitter ⚠
p.Val440Ile Single submitter ⚠
p.Val526Met Single submitter ⚠
p.Val706Leu Single submitter ⚠
p.Val751Gly Single submitter ⚠
p.Val798Ala Single submitter ⚠
p.Val841Ile Single submitter ⚠
p.Val969Ala Single submitter ⚠