ITGAL — 108 ClinVar variants
All ClinVar germline ITGAL variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 85 flagged for review →
6 Benign · 1 Benign/Likely benign · 13 Likely benign · 88 Uncertain significance
Full ITGAL gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 85
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 70
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- ITGAL p.Ala1072Thr Uncertain significance Single submitter
- ITGAL p.Ala1127Pro Uncertain significance Single submitter
- ITGAL p.Ala1149Pro Uncertain significance Single submitter
- ITGAL p.Ala33Thr Uncertain significance Single submitter
- ITGAL p.Ala363Thr Uncertain significance Single submitter
- ITGAL p.Ala482Asp Uncertain significance Single submitter
- ITGAL p.Ala527Ser Uncertain significance Single submitter
- ITGAL p.Ala799Asp Uncertain significance Single submitter
- ITGAL p.Arg246Gln Uncertain significance Single submitter
- ITGAL p.Arg520Gln Uncertain significance Single submitter
- ITGAL p.Arg741Lys Uncertain significance Single submitter
- ITGAL p.Arg956Lys Uncertain significance Single submitter
- ITGAL p.Asn238Ser Uncertain significance Single submitter
- ITGAL p.Asn897His Uncertain significance Single submitter
- ITGAL p.Asn897Ser Uncertain significance Single submitter
- ITGAL p.Asp1170Asn Uncertain significance Single submitter
- ITGAL p.Asp120Gly Uncertain significance Single submitter
- ITGAL p.Asp322Val Uncertain significance Single submitter
- ITGAL p.Asp709Glu Uncertain significance Single submitter
- ITGAL p.Cys111Tyr Uncertain significance Single submitter
- ITGAL p.Gln1032Glu Uncertain significance Single submitter
- ITGAL p.Gln428Glu Uncertain significance Single submitter
- ITGAL p.Gln548Glu Uncertain significance Single submitter
- ITGAL p.Gln954Arg Uncertain significance Single submitter
- ITGAL p.Gln991Arg Uncertain significance Single submitter
- ITGAL p.Glu1164Gly Uncertain significance Single submitter
- ITGAL p.Glu761Gly Uncertain significance Single submitter
- ITGAL p.Glu778Asp Uncertain significance Single submitter
- ITGAL p.Glu850Gly Uncertain significance Single submitter
- ITGAL p.Gly1153Ser Uncertain significance Single submitter
- ITGAL p.Gly68Arg Uncertain significance Single submitter
- ITGAL p.Gly747Asp Uncertain significance Single submitter
- ITGAL p.His226Pro Uncertain significance Single submitter
- ITGAL p.His759Arg Uncertain significance Single submitter
- ITGAL p.His962Arg Uncertain significance Single submitter
- ITGAL p.Ile283Leu Uncertain significance Single submitter
- ITGAL p.Ile451Met Uncertain significance Single submitter
- ITGAL p.Ile553Leu Uncertain significance Single submitter
- ITGAL p.Ile608Met Uncertain significance Single submitter
- ITGAL p.Leu591Phe Uncertain significance Single submitter
- ITGAL p.Leu795Val Uncertain significance Single submitter
- ITGAL p.Lys1161Asn Uncertain significance Single submitter
- ITGAL p.Lys293Glu Uncertain significance Single submitter
- ITGAL p.Lys657Thr Uncertain significance Single submitter
- ITGAL p.Lys945Asn Uncertain significance Single submitter
- ITGAL p.Met1048Val Uncertain significance Single submitter
- ITGAL p.Met430Lys Uncertain significance Single submitter
- ITGAL p.Met644Leu Uncertain significance Single submitter
- ITGAL p.Phe829Cys Uncertain significance Single submitter
- ITGAL p.Pro1007Leu Uncertain significance Single submitter
- ITGAL p.Pro22Leu Uncertain significance Single submitter
- ITGAL p.Pro751Leu Uncertain significance Single submitter
- ITGAL p.Pro825Leu Uncertain significance Single submitter
- ITGAL p.Pro825Thr Uncertain significance Single submitter
- ITGAL p.Pro976Ser Uncertain significance Single submitter
- ITGAL p.Ser308Asn Uncertain significance Single submitter
- ITGAL p.Ser35Arg Uncertain significance Single submitter
- ITGAL p.Ser418Leu Uncertain significance Single submitter
- ITGAL p.Ser760Leu Uncertain significance Single submitter
- ITGAL p.Thr475Ile Uncertain significance Single submitter
- ITGAL p.Thr572Asn Uncertain significance Single submitter
- ITGAL p.Thr739Ala Uncertain significance Single submitter
- ITGAL p.Tyr1000Cys Uncertain significance Single submitter
- ITGAL p.Tyr406Ser Uncertain significance Single submitter
- ITGAL p.Tyr638Cys Uncertain significance Single submitter
- ITGAL p.Val365Met Uncertain significance Single submitter
- ITGAL p.Val408Leu Uncertain significance Single submitter
- ITGAL p.Val609Met Uncertain significance Single submitter
- ITGAL p.Val884Ala Uncertain significance Single submitter
-
ITGAL p.Arg34Gln
Uncertain significance
No assertion criteria
myoepithelial tumor
Predictors split 15
The independent predictors disagree with each other — read with care.
- ITGAL p.Arg1020His Benign/Likely benign Multiple submitters
- ITGAL p.Ala1045Pro Uncertain significance Single submitter
- ITGAL p.Ala421Ser Uncertain significance Single submitter
- ITGAL p.Arg252Gln Uncertain significance Single submitter
- ITGAL p.Arg520Trp Uncertain significance Single submitter
- ITGAL p.Glu1126Ala Uncertain significance Single submitter
- ITGAL p.Ile390Thr Uncertain significance Single submitter
- ITGAL p.Leu1103Met Uncertain significance Single submitter
- ITGAL p.Leu479Val Uncertain significance Single submitter
- ITGAL p.Met1125Ile Uncertain significance Single submitter
- ITGAL p.Pro113Ser Uncertain significance Single submitter
- ITGAL p.Pro145Leu Uncertain significance Single submitter
- ITGAL p.Pro994Ser Uncertain significance Single submitter
- ITGAL p.Ser66Cys Uncertain significance Single submitter
- ITGAL p.Val615Met Uncertain significance Single submitter
All ITGAL variants
Benign 6
- c.1213+9T>G Multiple submitters
- p.Ala307= Multiple submitters
- p.Pro1152= Multiple submitters
- p.Ser891= Multiple submitters
- c.1080+5G>A Single submitter
- p.Arg144His Single submitter
Benign/Likely benign 1
- p.Arg1020His Multiple submitters ⚠
Likely benign 13
- p.Ala219Val Single submitter
- p.Ala307Val Single submitter
- p.Arg414Gln Single submitter
- p.Arg432Gln Single submitter
- p.Arg666His Single submitter
- p.Ile496Val Single submitter
- p.Ile652Val Single submitter
- p.Leu160= Single submitter
- p.Leu502= Single submitter
- p.Pro1132Ser Single submitter
- p.Ser891Leu Single submitter
- p.Thr396= Single submitter
- p.Val467Ile Single submitter
Uncertain significance 88
- p.Ala1045Pro Single submitter ⚠
- p.Ala1072Thr Single submitter ⚠
- p.Ala1127Pro Single submitter ⚠
- p.Ala1149Pro Single submitter ⚠
- p.Ala33Thr Single submitter ⚠
- p.Ala363Thr Single submitter ⚠
- p.Ala421Ser Single submitter ⚠
- p.Ala482Asp Single submitter ⚠
- p.Ala524Asp Single submitter
- p.Ala527Ser Single submitter ⚠
- p.Ala799Asp Single submitter ⚠
- p.Arg246Gln Single submitter ⚠
- p.Arg252Gln Single submitter ⚠
- p.Arg520Gln Single submitter ⚠
- p.Arg520Trp Single submitter ⚠
- p.Arg741Lys Single submitter ⚠
- p.Arg956Lys Single submitter ⚠
- p.Asn238Ser Single submitter ⚠
- p.Asn897His Single submitter ⚠
- p.Asn897Ser Single submitter ⚠
- p.Asp1170Asn Single submitter ⚠
- p.Asp120Gly Single submitter ⚠
- p.Asp322Val Single submitter ⚠
- p.Asp709Glu Single submitter ⚠
- p.Cys111Tyr Single submitter ⚠
- p.Gln1032Glu Single submitter ⚠
- p.Gln428Glu Single submitter ⚠
- p.Gln548Glu Single submitter ⚠
- p.Gln954Arg Single submitter ⚠
- p.Gln991Arg Single submitter ⚠
- p.Glu1126Ala Single submitter ⚠
- p.Glu1164Gly Single submitter ⚠
- p.Glu761Gly Single submitter ⚠
- p.Glu778Asp Single submitter ⚠
- p.Glu850Gly Single submitter ⚠
- p.Gly1153Ser Single submitter ⚠
- p.Gly68Arg Single submitter ⚠
- p.Gly747Asp Single submitter ⚠
- p.Gly826Arg Single submitter
- p.His226Pro Single submitter ⚠
- p.His759Arg Single submitter ⚠
- p.His962Arg Single submitter ⚠
- p.Ile283Leu Single submitter ⚠
- p.Ile390Thr Single submitter ⚠
- p.Ile451Met Single submitter ⚠
- p.Ile553Leu Single submitter ⚠
- p.Ile608Met Single submitter ⚠
- p.Leu1103Met Single submitter ⚠
- p.Leu479Val Single submitter ⚠
- p.Leu591Phe Single submitter ⚠
- p.Leu795Val Single submitter ⚠
- p.Lys1161Asn Single submitter ⚠
- p.Lys293Glu Single submitter ⚠
- p.Lys319Asn Single submitter
- p.Lys657Thr Single submitter ⚠
- p.Lys945Asn Single submitter ⚠
- p.Met1048Val Single submitter ⚠
- p.Met1125Ile Single submitter ⚠
- p.Met430Lys Single submitter ⚠
- p.Met644Leu Single submitter ⚠
- p.Phe829Cys Single submitter ⚠
- p.Pro1007Leu Single submitter ⚠
- p.Pro113Ser Single submitter ⚠
- p.Pro145Leu Single submitter ⚠
- p.Pro22Leu Single submitter ⚠
- p.Pro751Leu Single submitter ⚠
- p.Pro766Arg Single submitter
- p.Pro825Leu Single submitter ⚠
- p.Pro825Thr Single submitter ⚠
- p.Pro976Ser Single submitter ⚠
- p.Pro994Ser Single submitter ⚠
- p.Ser308Asn Single submitter ⚠
- p.Ser35Arg Single submitter ⚠
- p.Ser418Leu Single submitter ⚠
- p.Ser66Cys Single submitter ⚠
- p.Ser760Leu Single submitter ⚠
- p.Thr475Ile Single submitter ⚠
- p.Thr572Asn Single submitter ⚠
- p.Thr739Ala Single submitter ⚠
- p.Tyr1000Cys Single submitter ⚠
- p.Tyr406Ser Single submitter ⚠
- p.Tyr638Cys Single submitter ⚠
- p.Val365Met Single submitter ⚠
- p.Val408Leu Single submitter ⚠
- p.Val609Met Single submitter ⚠
- p.Val615Met Single submitter ⚠
- p.Val884Ala Single submitter ⚠
- p.Arg34Gln No assertion criteria myoepithelial tumor ⚠