JMJD6 — 48 ClinVar variants
All ClinVar germline JMJD6 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 45 flagged for review →
1 Benign · 47 Uncertain significance
Full JMJD6 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 45
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 33
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- JMJD6 p.Ala40Thr Uncertain significance Single submitter
- JMJD6 p.Ala49Glu Uncertain significance Single submitter
- JMJD6 p.Ala51Val Uncertain significance Single submitter
- JMJD6 p.Arg373Cys Uncertain significance Single submitter
- JMJD6 p.Asn2Thr Uncertain significance Single submitter
- JMJD6 p.Asn74Ser Uncertain significance Single submitter
- JMJD6 p.Asp368Asn Uncertain significance Single submitter
- JMJD6 p.Gln201Lys Uncertain significance Single submitter
- JMJD6 p.Gln82Arg Uncertain significance Single submitter
- JMJD6 p.Glu33Lys Uncertain significance Single submitter
- JMJD6 p.Glu362Lys Uncertain significance Single submitter
- JMJD6 p.Glu366Lys Uncertain significance Single submitter
- JMJD6 p.Gly192Arg Uncertain significance Single submitter
- JMJD6 p.Gly384Glu Uncertain significance Single submitter
- JMJD6 p.Gly386Arg Uncertain significance Single submitter
- JMJD6 p.His372Arg Uncertain significance Single submitter
- JMJD6 p.Ile284Val Uncertain significance Single submitter
- JMJD6 p.Lys111Glu Uncertain significance Single submitter
- JMJD6 p.Lys311Glu Uncertain significance Single submitter
- JMJD6 p.Pro141Ser Uncertain significance Single submitter
- JMJD6 p.Pro210Ala Uncertain significance Single submitter
- JMJD6 p.Pro214Ala Uncertain significance Single submitter
- JMJD6 p.Pro254Leu Uncertain significance Single submitter
- JMJD6 p.Pro254Thr Uncertain significance Single submitter
- JMJD6 p.Pro261Thr Uncertain significance Single submitter
- JMJD6 p.Pro69Leu Uncertain significance Single submitter
- JMJD6 p.Ser123Asn Uncertain significance Single submitter
- JMJD6 p.Ser15Thr Uncertain significance Single submitter
- JMJD6 p.Ser34Asn Uncertain significance Single submitter
- JMJD6 p.Tyr108Cys Uncertain significance Single submitter
- JMJD6 p.Val274Ile Uncertain significance Single submitter
- JMJD6 p.Val330Ile Uncertain significance Single submitter
- JMJD6 p.Val371Gly Uncertain significance Single submitter
Predictors split 12
The independent predictors disagree with each other — read with care.
- JMJD6 p.Arg242Gln Uncertain significance Single submitter
- JMJD6 p.Arg28Gly Uncertain significance Single submitter
- JMJD6 p.Arg92Thr Uncertain significance Single submitter
- JMJD6 p.His203Gln Uncertain significance Single submitter
- JMJD6 p.Leu217Phe Uncertain significance Single submitter
- JMJD6 p.Lys260Asn Uncertain significance Single submitter
- JMJD6 p.Ser329Trp Uncertain significance Single submitter
- JMJD6 p.Ser352Ala Uncertain significance Single submitter
- JMJD6 p.Ser359Leu Uncertain significance Single submitter
- JMJD6 p.Ser363Cys Uncertain significance Single submitter
- JMJD6 p.Ser365Tyr Uncertain significance Single submitter
- JMJD6 p.Ser55Cys Uncertain significance Single submitter
All JMJD6 variants
Benign 1
- p.Asp159= Multiple submitters
Uncertain significance 47
- p.Ala40Thr Single submitter ⚠
- p.Ala49Glu Single submitter ⚠
- p.Ala51Val Single submitter ⚠
- p.Arg242Gln Single submitter ⚠
- p.Arg28Gly Single submitter ⚠
- p.Arg373Cys Single submitter ⚠
- p.Arg411Gln Single submitter
- p.Arg92Thr Single submitter ⚠
- p.Asn2Thr Single submitter ⚠
- p.Asn74Ser Single submitter ⚠
- p.Asp368Asn Single submitter ⚠
- p.Gln201Lys Single submitter ⚠
- p.Gln82Arg Single submitter ⚠
- p.Glu33Lys Single submitter ⚠
- p.Glu362Lys Single submitter ⚠
- p.Glu366Lys Single submitter ⚠
- p.Gly192Arg Single submitter ⚠
- p.Gly384Glu Single submitter ⚠
- p.Gly386Arg Single submitter ⚠
- p.His203Gln Single submitter ⚠
- p.His372Arg Single submitter ⚠
- p.Ile284Val Single submitter ⚠
- p.Leu217Phe Single submitter ⚠
- p.Lys111Glu Single submitter ⚠
- p.Lys260Asn Single submitter ⚠
- p.Lys311fs Single submitter
- p.Lys311Glu Single submitter ⚠
- p.Pro141Ser Single submitter ⚠
- p.Pro210Ala Single submitter ⚠
- p.Pro214Ala Single submitter ⚠
- p.Pro254Leu Single submitter ⚠
- p.Pro254Thr Single submitter ⚠
- p.Pro261Thr Single submitter ⚠
- p.Pro69Leu Single submitter ⚠
- p.Ser123Asn Single submitter ⚠
- p.Ser15Thr Single submitter ⚠
- p.Ser329Trp Single submitter ⚠
- p.Ser34Asn Single submitter ⚠
- p.Ser352Ala Single submitter ⚠
- p.Ser359Leu Single submitter ⚠
- p.Ser363Cys Single submitter ⚠
- p.Ser365Tyr Single submitter ⚠
- p.Ser55Cys Single submitter ⚠
- p.Tyr108Cys Single submitter ⚠
- p.Val274Ile Single submitter ⚠
- p.Val330Ile Single submitter ⚠
- p.Val371Gly Single submitter ⚠