JUN — 24 ClinVar variants
All ClinVar germline JUN variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 21 flagged for review →
1 Pathogenic · 1 Benign · 1 Likely benign · 21 Uncertain significance
Full JUN gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 21
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 19
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- JUN p.Ala148Val Uncertain significance Single submitter
- JUN p.Ala161Ser Uncertain significance Single submitter
- JUN p.Ala187Ser Uncertain significance Single submitter
- JUN p.Ala224Gly Uncertain significance Single submitter
- JUN p.Asn175Asp Uncertain significance Single submitter
- JUN p.Gln218Arg Uncertain significance Single submitter
- JUN p.Gln290Arg Uncertain significance Single submitter
- JUN p.Gln290Glu Uncertain significance Single submitter
- JUN p.Glu303Val Uncertain significance Single submitter
- JUN p.Gly157Cys Uncertain significance Single submitter
- JUN p.Gly158Asp Uncertain significance Single submitter
- JUN p.Leu14Phe Uncertain significance Single submitter
- JUN p.Lys288Ile Uncertain significance Single submitter
- JUN p.Pro207Gln Uncertain significance Single submitter
- JUN p.Pro220Ala Uncertain significance Single submitter
- JUN p.Pro94Arg Uncertain significance Single submitter
- JUN p.Ser132Pro Uncertain significance Single submitter
- JUN p.Ser182Asn Uncertain significance Single submitter
- JUN p.Val130Ala Uncertain significance Single submitter
Predictors split 2
The independent predictors disagree with each other — read with care.
All JUN variants
Pathogenic 1
- p.Pro220fs No assertion criteria breast neoplasm
Benign 1
- p.Ser73= Single submitter
Likely benign 1
- p.Gly155= Single submitter
Uncertain significance 21
- p.Ala148Val Single submitter ⚠
- p.Ala161Ser Single submitter ⚠
- p.Ala187Ser Single submitter ⚠
- p.Ala224Gly Single submitter ⚠
- p.Asn175Asp Single submitter ⚠
- p.Asn314Lys Single submitter ⚠
- p.Gln218Arg Single submitter ⚠
- p.Gln290Arg Single submitter ⚠
- p.Gln290Glu Single submitter ⚠
- p.Glu303Val Single submitter ⚠
- p.Gly157Cys Single submitter ⚠
- p.Gly158Asp Single submitter ⚠
- p.Leu14Phe Single submitter ⚠
- p.Leu173Val Single submitter ⚠
- p.Lys288Ile Single submitter ⚠
- p.Pro207Gln Single submitter ⚠
- p.Pro220Ala Single submitter ⚠
- p.Pro94Arg Single submitter ⚠
- p.Ser132Pro Single submitter ⚠
- p.Ser182Asn Single submitter ⚠
- p.Val130Ala Single submitter ⚠