Sugi Variant

Sugi Variant/KANK1

KANK1 — 1129 ClinVar variants

All ClinVar germline KANK1 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 591 flagged for review →

1 Likely pathogenic · 62 Conflicting · 85 Benign · 42 Benign/Likely benign · 315 Likely benign · 624 Uncertain significance

Full KANK1 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions

⚑ Evidence disagreements 591

Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.

Predictors vs ClinVar 1

ClinVar calls these pathogenic, but the computational predictors lean tolerated — the highest-value review flag.

Predictors agree, ClinVar conflicts 46

ClinVar submitters conflict, but the independent predictors unanimously agree — a QC review flag, not a reclassification.

Predictors lean, ClinVar uncertain 462

ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification. · showing the 150 best-reviewed of 462

Predictors split 82

The independent predictors disagree with each other — read with care.

All KANK1 variants

Likely pathogenic 1

Conflicting classifications of pathogenicity 62

Benign 85

Benign/Likely benign 42

Likely benign 315

Showing the top 300 by review status; the full set is in the sitemap.

Uncertain significance 624

Showing the top 300 by review status; the full set is in the sitemap.