KAT7 — 54 ClinVar variants
All ClinVar germline KAT7 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 48 flagged for review →
1 Benign · 53 Uncertain significance
Full KAT7 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 48
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 34
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- KAT7 p.Ala133Val Uncertain significance Single submitter
- KAT7 p.Ala154Thr Uncertain significance Single submitter
- KAT7 p.Ala40Thr Uncertain significance Single submitter
- KAT7 p.Ala8Val Uncertain significance Single submitter
- KAT7 p.Arg344Leu Uncertain significance Single submitter
- KAT7 p.Arg37Gln Uncertain significance Single submitter
- KAT7 p.Asn595Ser Uncertain significance Single submitter
- KAT7 p.Gln546Glu Uncertain significance Single submitter
- KAT7 p.Glu123Lys Uncertain significance Single submitter
- KAT7 p.Glu219Lys Uncertain significance Single submitter
- KAT7 p.Glu25Gly Uncertain significance Single submitter
- KAT7 p.Glu278Asp Uncertain significance Single submitter
- KAT7 p.Gly402Ser Uncertain significance Single submitter
- KAT7 p.His168Arg Uncertain significance Single submitter
- KAT7 p.His238Tyr Uncertain significance Single submitter
- KAT7 p.Ile140Thr Uncertain significance Single submitter
- KAT7 p.Ile153Thr Uncertain significance Single submitter
- KAT7 p.Ile340Val Uncertain significance Single submitter
- KAT7 p.Ile404Val Uncertain significance Single submitter
- KAT7 p.Leu24Pro Uncertain significance Single submitter
- KAT7 p.Lys391Gln Uncertain significance Single submitter
- KAT7 p.Lys537Gln Uncertain significance Single submitter
- KAT7 p.Lys537Glu Uncertain significance Single submitter
- KAT7 p.Lys566Thr Uncertain significance Single submitter
- KAT7 p.Met157Ile Uncertain significance Single submitter
- KAT7 p.Pro86Ala Uncertain significance Single submitter
- KAT7 p.Pro93His Uncertain significance Single submitter
- KAT7 p.Ser135Pro Uncertain significance Single submitter
- KAT7 p.Ser273Ala Uncertain significance Single submitter
- KAT7 p.Ser494Gly Uncertain significance Single submitter
- KAT7 p.Ser53Pro Uncertain significance Single submitter
- KAT7 p.Thr118Ala Uncertain significance Single submitter
- KAT7 p.Thr379Met Uncertain significance Single submitter
- KAT7 p.Tyr212Phe Uncertain significance Single submitter
Predictors split 14
The independent predictors disagree with each other — read with care.
- KAT7 p.Arg382His Uncertain significance Single submitter
- KAT7 p.Arg6Thr Uncertain significance Single submitter
- KAT7 p.Arg75Gly Uncertain significance Single submitter
- KAT7 p.Arg79Cys Uncertain significance Single submitter
- KAT7 p.Arg98Cys Uncertain significance Single submitter
- KAT7 p.Gly274Glu Uncertain significance Single submitter
- KAT7 p.Gly610Arg Uncertain significance Single submitter
- KAT7 p.His176Gln Uncertain significance Single submitter
- KAT7 p.His286Leu Uncertain significance Single submitter
- KAT7 p.Lys609Asn Uncertain significance Single submitter
- KAT7 p.Ser46Leu Uncertain significance Single submitter
- KAT7 p.Thr254Met Uncertain significance Single submitter
- KAT7 p.Thr339Ile Uncertain significance Single submitter
- KAT7 p.Tyr260His Uncertain significance Single submitter
All KAT7 variants
Benign 1
- p.Ala449= Multiple submitters
Uncertain significance 53
- c.580+1G>A Single submitter
- p.Ala133Val Single submitter ⚠
- p.Ala154Thr Single submitter ⚠
- p.Ala40Thr Single submitter ⚠
- p.Ala8Val Single submitter ⚠
- p.Arg344Leu Single submitter ⚠
- p.Arg37Gln Single submitter ⚠
- p.Arg382His Single submitter ⚠
- p.Arg6Thr Single submitter ⚠
- p.Arg75Gly Single submitter ⚠
- p.Arg79Cys Single submitter ⚠
- p.Arg98Cys Single submitter ⚠
- p.Asn595Ser Single submitter ⚠
- p.Gln546Glu Single submitter ⚠
- p.Glu123Lys Single submitter ⚠
- p.Glu219Lys Single submitter ⚠
- p.Glu25Gly Single submitter ⚠
- p.Glu278Asp Single submitter ⚠
- p.Gly274Glu Single submitter ⚠
- p.Gly402Ser Single submitter ⚠
- p.Gly610Arg Single submitter ⚠
- p.His168Arg Single submitter ⚠
- p.His176Gln Single submitter ⚠
- p.His238Tyr Single submitter ⚠
- p.His286Leu Single submitter ⚠
- p.Ile140Thr Single submitter ⚠
- p.Ile153Thr Single submitter ⚠
- p.Ile340Val Single submitter ⚠
- p.Ile404Val Single submitter ⚠
- p.Ile544Met Single submitter
- p.Leu24Pro Single submitter ⚠
- p.Lys391Gln Single submitter ⚠
- p.Lys537Gln Single submitter ⚠
- p.Lys537Glu Single submitter ⚠
- p.Lys566Thr Single submitter ⚠
- p.Lys609Asn Single submitter ⚠
- p.Met157Ile Single submitter ⚠
- p.Pro86Ala Single submitter ⚠
- p.Pro93His Single submitter ⚠
- p.Ser135Pro Single submitter ⚠
- p.Ser178fs Single submitter
- p.Ser273Ala Single submitter ⚠
- p.Ser46Leu Single submitter ⚠
- p.Ser494Gly Single submitter ⚠
- p.Ser53Pro Single submitter ⚠
- p.Thr118Ala Single submitter ⚠
- p.Thr254Met Single submitter ⚠
- p.Thr293Ile Single submitter
- p.Thr339Ile Single submitter ⚠
- p.Thr379Met Single submitter ⚠
- p.Tyr212Phe Single submitter ⚠
- p.Tyr260His Single submitter ⚠
- p.Gln563Ter No assertion criteria prostate cancer