KATNA1 — 65 ClinVar variants
All ClinVar germline KATNA1 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 65 flagged for review →
65 Uncertain significance
Full KATNA1 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 65
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 51
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- KATNA1 p.Ala172Val Uncertain significance Single submitter
- KATNA1 p.Ala217Pro Uncertain significance Single submitter
- KATNA1 p.Ala25Val Uncertain significance Single submitter
- KATNA1 p.Ala297Gly Uncertain significance Single submitter
- KATNA1 p.Ala428Gly Uncertain significance Single submitter
- KATNA1 p.Ala85Pro Uncertain significance Single submitter
- KATNA1 p.Ala85Val Uncertain significance Single submitter
- KATNA1 p.Arg115Cys Uncertain significance Single submitter
- KATNA1 p.Arg115His Uncertain significance Single submitter
- KATNA1 p.Arg129His Uncertain significance Single submitter
- KATNA1 p.Arg135Thr Uncertain significance Single submitter
- KATNA1 p.Arg14Cys Uncertain significance Single submitter
- KATNA1 p.Arg14His Uncertain significance Single submitter
- KATNA1 p.Arg153Cys Uncertain significance Single submitter
- KATNA1 p.Arg153His Uncertain significance Single submitter
- KATNA1 p.Arg155Cys Uncertain significance Single submitter
- KATNA1 p.Arg155His Uncertain significance Single submitter
- KATNA1 p.Arg291His Uncertain significance Single submitter
- KATNA1 p.Arg317Gln Uncertain significance Single submitter
- KATNA1 p.Arg392Gln Uncertain significance Single submitter
- KATNA1 p.Asn128Ser Uncertain significance Single submitter
- KATNA1 p.Asn146Asp Uncertain significance Single submitter
- KATNA1 p.Asn60Tyr Uncertain significance Single submitter
- KATNA1 p.Asp122Glu Uncertain significance Single submitter
- KATNA1 p.Asp364Ala Uncertain significance Single submitter
- KATNA1 p.Asp477Tyr Uncertain significance Single submitter
- KATNA1 p.Asp68Gly Uncertain significance Single submitter
- KATNA1 p.Glu156Lys Uncertain significance Single submitter
- KATNA1 p.Glu96Lys Uncertain significance Single submitter
- KATNA1 p.Gly249Ser Uncertain significance Single submitter
- KATNA1 p.Gly418Ser Uncertain significance Single submitter
- KATNA1 p.Ile377Met Uncertain significance Single submitter
- KATNA1 p.Ile393Val Uncertain significance Single submitter
- KATNA1 p.Leu391Phe Uncertain significance Single submitter
- KATNA1 p.Leu3Val Uncertain significance Single submitter
- KATNA1 p.Leu406Pro Uncertain significance Single submitter
- KATNA1 p.Lys150Arg Uncertain significance Single submitter
- KATNA1 p.Lys236Asn Uncertain significance Single submitter
- KATNA1 p.Lys67Thr Uncertain significance Single submitter
- KATNA1 p.Met26Val Uncertain significance Single submitter
- KATNA1 p.Met36Ile Uncertain significance Single submitter
- KATNA1 p.Met70Val Uncertain significance Single submitter
- KATNA1 p.Phe486Leu Uncertain significance Single submitter
- KATNA1 p.Pro130Ser Uncertain significance Single submitter
- KATNA1 p.Ser184Gly Uncertain significance Single submitter
- KATNA1 p.Ser24Phe Uncertain significance Single submitter
- KATNA1 p.Thr264Ile Uncertain significance Single submitter
- KATNA1 p.Tyr22Cys Uncertain significance Single submitter
- KATNA1 p.Tyr378Cys Uncertain significance Single submitter
- KATNA1 p.Val102Ile Uncertain significance Single submitter
- KATNA1 p.Val10Ala Uncertain significance Single submitter
Predictors split 14
The independent predictors disagree with each other — read with care.
- KATNA1 p.Arg107Gly Uncertain significance Single submitter
- KATNA1 p.Arg396Cys Uncertain significance Single submitter
- KATNA1 p.Arg436Cys Uncertain significance Single submitter
- KATNA1 p.Arg446Gln Uncertain significance Single submitter
- KATNA1 p.Asn9Lys Uncertain significance Single submitter
- KATNA1 p.Asp348Ala Uncertain significance Single submitter
- KATNA1 p.Ile305Val Uncertain significance Single submitter
- KATNA1 p.Ile485Val Uncertain significance Single submitter
- KATNA1 p.Leu406Phe Uncertain significance Single submitter
- KATNA1 p.Lys219Gln Uncertain significance Single submitter
- KATNA1 p.Lys483Arg Uncertain significance Single submitter
- KATNA1 p.Met229Val Uncertain significance Single submitter
- KATNA1 p.Met352Val Uncertain significance Single submitter
- KATNA1 p.Val225Ile Uncertain significance Single submitter
All KATNA1 variants
Uncertain significance 65
- p.Ala172Val Single submitter ⚠
- p.Ala217Pro Single submitter ⚠
- p.Ala25Val Single submitter ⚠
- p.Ala297Gly Single submitter ⚠
- p.Ala428Gly Single submitter ⚠
- p.Ala85Pro Single submitter ⚠
- p.Ala85Val Single submitter ⚠
- p.Arg107Gly Single submitter ⚠
- p.Arg115Cys Single submitter ⚠
- p.Arg115His Single submitter ⚠
- p.Arg129His Single submitter ⚠
- p.Arg135Thr Single submitter ⚠
- p.Arg14Cys Single submitter ⚠
- p.Arg14His Single submitter ⚠
- p.Arg153Cys Single submitter ⚠
- p.Arg153His Single submitter ⚠
- p.Arg155Cys Single submitter ⚠
- p.Arg155His Single submitter ⚠
- p.Arg291His Single submitter ⚠
- p.Arg317Gln Single submitter ⚠
- p.Arg392Gln Single submitter ⚠
- p.Arg396Cys Single submitter ⚠
- p.Arg436Cys Single submitter ⚠
- p.Arg446Gln Single submitter ⚠
- p.Asn128Ser Single submitter ⚠
- p.Asn146Asp Single submitter ⚠
- p.Asn60Tyr Single submitter ⚠
- p.Asn9Lys Single submitter ⚠
- p.Asp122Glu Single submitter ⚠
- p.Asp348Ala Single submitter ⚠
- p.Asp364Ala Single submitter ⚠
- p.Asp477Tyr Single submitter ⚠
- p.Asp68Gly Single submitter ⚠
- p.Glu156Lys Single submitter ⚠
- p.Glu96Lys Single submitter ⚠
- p.Gly249Ser Single submitter ⚠
- p.Gly418Ser Single submitter ⚠
- p.Ile305Val Single submitter ⚠
- p.Ile377Met Single submitter ⚠
- p.Ile393Val Single submitter ⚠
- p.Ile485Val Single submitter ⚠
- p.Leu391Phe Single submitter ⚠
- p.Leu3Val Single submitter ⚠
- p.Leu406Phe Single submitter ⚠
- p.Leu406Pro Single submitter ⚠
- p.Lys150Arg Single submitter ⚠
- p.Lys219Gln Single submitter ⚠
- p.Lys236Asn Single submitter ⚠
- p.Lys483Arg Single submitter ⚠
- p.Lys67Thr Single submitter ⚠
- p.Met229Val Single submitter ⚠
- p.Met26Val Single submitter ⚠
- p.Met352Val Single submitter ⚠
- p.Met36Ile Single submitter ⚠
- p.Met70Val Single submitter ⚠
- p.Phe486Leu Single submitter ⚠
- p.Pro130Ser Single submitter ⚠
- p.Ser184Gly Single submitter ⚠
- p.Ser24Phe Single submitter ⚠
- p.Thr264Ile Single submitter ⚠
- p.Tyr22Cys Single submitter ⚠
- p.Tyr378Cys Single submitter ⚠
- p.Val102Ile Single submitter ⚠
- p.Val10Ala Single submitter ⚠
- p.Val225Ile Single submitter ⚠