Sugi Variant

Sugi Variant/KCNA6

KCNA6 — 82 ClinVar variants

All ClinVar germline KCNA6 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 70 flagged for review →

1 Pathogenic · 2 Likely pathogenic · 1 Conflicting · 2 Likely benign · 76 Uncertain significance

Full KCNA6 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions

⚑ Evidence disagreements 70

Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.

Predictors agree, ClinVar conflicts 1

ClinVar submitters conflict, but the independent predictors unanimously agree — a QC review flag, not a reclassification.

Predictors lean, ClinVar uncertain 60

ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.

Predictors split 9

The independent predictors disagree with each other — read with care.

All KCNA6 variants

Pathogenic 1

Likely pathogenic 2

Conflicting classifications of pathogenicity 1

Likely benign 2

Uncertain significance 76