KCNA7 — 88 ClinVar variants
All ClinVar germline KCNA7 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 84 flagged for review →
88 Uncertain significance
Full KCNA7 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 84
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 74
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- KCNA7 p.Ala141Thr Uncertain significance Single submitter
- KCNA7 p.Ala178Asp Uncertain significance Single submitter
- KCNA7 p.Ala182Thr Uncertain significance Single submitter
- KCNA7 p.Ala188Thr Uncertain significance Single submitter
- KCNA7 p.Ala188Val Uncertain significance Single submitter
- KCNA7 p.Ala235Val Uncertain significance Single submitter
- KCNA7 p.Ala275Thr Uncertain significance Single submitter
- KCNA7 p.Ala28Glu Uncertain significance Single submitter
- KCNA7 p.Ala329Thr Uncertain significance Single submitter
- KCNA7 p.Ala333Asp Uncertain significance Single submitter
- KCNA7 p.Ala352Val Uncertain significance Single submitter
- KCNA7 p.Ala381Val Uncertain significance Single submitter
- KCNA7 p.Ala52Val Uncertain significance Single submitter
- KCNA7 p.Arg107Ser Uncertain significance Single submitter
- KCNA7 p.Arg202Cys Uncertain significance Single submitter
- KCNA7 p.Arg263Pro Uncertain significance Single submitter
- KCNA7 p.Arg27Gly Uncertain significance Single submitter
- KCNA7 p.Arg284His Uncertain significance Single submitter
- KCNA7 p.Arg287Cys Uncertain significance Single submitter
- KCNA7 p.Arg287His Uncertain significance Single submitter
- KCNA7 p.Arg293Trp Uncertain significance Single submitter
- KCNA7 p.Arg337Trp Uncertain significance Single submitter
- KCNA7 p.Arg403Trp Uncertain significance Single submitter
- KCNA7 p.Arg44Ser Uncertain significance Single submitter
- KCNA7 p.Arg4Gln Uncertain significance Single submitter
- KCNA7 p.Arg80Gln Uncertain significance Single submitter
- KCNA7 p.Asn18Lys Uncertain significance Single submitter
- KCNA7 p.Asp41Tyr Uncertain significance Single submitter
- KCNA7 p.Asp41Val Uncertain significance Single submitter
- KCNA7 p.Asp50Gly Uncertain significance Single submitter
- KCNA7 p.Gln128Lys Uncertain significance Single submitter
- KCNA7 p.Glu455Lys Uncertain significance Single submitter
- KCNA7 p.Gly184Ser Uncertain significance Single submitter
- KCNA7 p.Gly258Asp Uncertain significance Single submitter
- KCNA7 p.Gly258Cys Uncertain significance Single submitter
- KCNA7 p.Gly297Arg Uncertain significance Single submitter
- KCNA7 p.Gly322Cys Uncertain significance Single submitter
- KCNA7 p.Gly322Ser Uncertain significance Single submitter
- KCNA7 p.Gly370Asp Uncertain significance Single submitter
- KCNA7 p.Gly407Asp Uncertain significance Single submitter
- KCNA7 p.Gly426Ser Uncertain significance Single submitter
- KCNA7 p.Gly426Val Uncertain significance Single submitter
- KCNA7 p.His83Pro Uncertain significance Single submitter
- KCNA7 p.Ile393Val Uncertain significance Single submitter
- KCNA7 p.Leu103Gln Uncertain significance Single submitter
- KCNA7 p.Leu120Arg Uncertain significance Single submitter
- KCNA7 p.Leu38Met Uncertain significance Single submitter
- KCNA7 p.Leu444Phe Uncertain significance Single submitter
- KCNA7 p.Leu69Ile Uncertain significance Single submitter
- KCNA7 p.Met412Leu Uncertain significance Single submitter
- KCNA7 p.Phe133Val Uncertain significance Single submitter
- KCNA7 p.Phe34Cys Uncertain significance Single submitter
- KCNA7 p.Phe89Leu Uncertain significance Single submitter
- KCNA7 p.Pro113Arg Uncertain significance Single submitter
- KCNA7 p.Pro121Ser Uncertain significance Single submitter
- KCNA7 p.Pro166Arg Uncertain significance Single submitter
- KCNA7 p.Pro185Gln Uncertain significance Single submitter
- KCNA7 p.Pro208Gln Uncertain significance Single submitter
- KCNA7 p.Pro208Leu Uncertain significance Single submitter
- KCNA7 p.Pro232Ala Uncertain significance Single submitter
- KCNA7 p.Pro346Leu Uncertain significance Single submitter
- KCNA7 p.Pro447Ser Uncertain significance Single submitter
- KCNA7 p.Pro448Gln Uncertain significance Single submitter
- KCNA7 p.Ser292Phe Uncertain significance Single submitter
- KCNA7 p.Thr175Arg Uncertain significance Single submitter
- KCNA7 p.Thr175Lys Uncertain significance Single submitter
- KCNA7 p.Tyr96His Uncertain significance Single submitter
- KCNA7 p.Val211Met Uncertain significance Single submitter
- KCNA7 p.Val241Leu Uncertain significance Single submitter
- KCNA7 p.Val241Met Uncertain significance Single submitter
- KCNA7 p.Val324Ala Uncertain significance Single submitter
- KCNA7 p.Val367Ile Uncertain significance Single submitter
- KCNA7 p.Val374Ala Uncertain significance Single submitter
- KCNA7 p.Val84Leu Uncertain significance Single submitter
Predictors split 10
The independent predictors disagree with each other — read with care.
- KCNA7 p.Arg263Trp Uncertain significance Single submitter
- KCNA7 p.Arg306Trp Uncertain significance Single submitter
- KCNA7 p.Arg403Gln Uncertain significance Single submitter
- KCNA7 p.Ile157Leu Uncertain significance Single submitter
- KCNA7 p.Ile316Leu Uncertain significance Single submitter
- KCNA7 p.Leu22Met Uncertain significance Single submitter
- KCNA7 p.Thr214Ser Uncertain significance Single submitter
- KCNA7 p.Val330Ile Uncertain significance Single submitter
- KCNA7 p.Val369Gly Uncertain significance Single submitter
- KCNA7 p.Val93Met Uncertain significance Single submitter
All KCNA7 variants
Uncertain significance 88
- p.Ala141Thr Single submitter ⚠
- p.Ala178Asp Single submitter ⚠
- p.Ala182Thr Single submitter ⚠
- p.Ala188Thr Single submitter ⚠
- p.Ala188Val Single submitter ⚠
- p.Ala235Val Single submitter ⚠
- p.Ala275Thr Single submitter ⚠
- p.Ala28Glu Single submitter ⚠
- p.Ala329Thr Single submitter ⚠
- p.Ala333Asp Single submitter ⚠
- p.Ala352Val Single submitter ⚠
- p.Ala381Val Single submitter ⚠
- p.Ala52Val Single submitter ⚠
- p.Arg107Ser Single submitter ⚠
- p.Arg202Cys Single submitter ⚠
- p.Arg263Pro Single submitter ⚠
- p.Arg263Trp Single submitter ⚠
- p.Arg27Gly Single submitter ⚠
- p.Arg284His Single submitter ⚠
- p.Arg287Cys Single submitter ⚠
- p.Arg287His Single submitter ⚠
- p.Arg293Trp Single submitter ⚠
- p.Arg306Trp Single submitter ⚠
- p.Arg337Trp Single submitter ⚠
- p.Arg403Gln Single submitter ⚠
- p.Arg403Trp Single submitter ⚠
- p.Arg44Ser Single submitter ⚠
- p.Arg4Gln Single submitter ⚠
- p.Arg80Gln Single submitter ⚠
- p.Asn18Lys Single submitter ⚠
- p.Asn191Ile Single submitter
- p.Asp41Tyr Single submitter ⚠
- p.Asp41Val Single submitter ⚠
- p.Asp50Gly Single submitter ⚠
- p.Cys12Trp Single submitter
- p.Gln128Lys Single submitter ⚠
- p.Glu13Lys Single submitter
- p.Glu455Lys Single submitter ⚠
- p.Gly184Ser Single submitter ⚠
- p.Gly258Asp Single submitter ⚠
- p.Gly258Cys Single submitter ⚠
- p.Gly297Arg Single submitter ⚠
- p.Gly322Cys Single submitter ⚠
- p.Gly322Ser Single submitter ⚠
- p.Gly370Asp Single submitter ⚠
- p.Gly407Asp Single submitter ⚠
- p.Gly426Ser Single submitter ⚠
- p.Gly426Val Single submitter ⚠
- p.His83Pro Single submitter ⚠
- p.Ile157Leu Single submitter ⚠
- p.Ile316Leu Single submitter ⚠
- p.Ile393Val Single submitter ⚠
- p.Leu103Gln Single submitter ⚠
- p.Leu120Arg Single submitter ⚠
- p.Leu22Met Single submitter ⚠
- p.Leu377Val Single submitter
- p.Leu38Met Single submitter ⚠
- p.Leu444Phe Single submitter ⚠
- p.Leu69Ile Single submitter ⚠
- p.Met412Leu Single submitter ⚠
- p.Phe133Val Single submitter ⚠
- p.Phe34Cys Single submitter ⚠
- p.Phe89Leu Single submitter ⚠
- p.Pro113Arg Single submitter ⚠
- p.Pro121Ser Single submitter ⚠
- p.Pro166Arg Single submitter ⚠
- p.Pro185Gln Single submitter ⚠
- p.Pro208Gln Single submitter ⚠
- p.Pro208Leu Single submitter ⚠
- p.Pro232Ala Single submitter ⚠
- p.Pro346Leu Single submitter ⚠
- p.Pro447Ser Single submitter ⚠
- p.Pro448Gln Single submitter ⚠
- p.Ser292Phe Single submitter ⚠
- p.Thr175Arg Single submitter ⚠
- p.Thr175Lys Single submitter ⚠
- p.Thr214Ser Single submitter ⚠
- p.Tyr96His Single submitter ⚠
- p.Val211Met Single submitter ⚠
- p.Val241Leu Single submitter ⚠
- p.Val241Met Single submitter ⚠
- p.Val324Ala Single submitter ⚠
- p.Val330Ile Single submitter ⚠
- p.Val367Ile Single submitter ⚠
- p.Val369Gly Single submitter ⚠
- p.Val374Ala Single submitter ⚠
- p.Val84Leu Single submitter ⚠
- p.Val93Met Single submitter ⚠