KCNK10 — 68 ClinVar variants
All ClinVar germline KCNK10 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 60 flagged for review →
1 Benign · 5 Likely benign · 62 Uncertain significance
Full KCNK10 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 60
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 45
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- KCNK10 p.Ala115Val Uncertain significance Single submitter
- KCNK10 p.Ala22Thr Uncertain significance Single submitter
- KCNK10 p.Ala293Ser Uncertain significance Single submitter
- KCNK10 p.Ala293Thr Uncertain significance Single submitter
- KCNK10 p.Ala41Thr Uncertain significance Single submitter
- KCNK10 p.Arg119Gln Uncertain significance Single submitter
- KCNK10 p.Arg373Trp Uncertain significance Single submitter
- KCNK10 p.Arg378Cys Uncertain significance Single submitter
- KCNK10 p.Arg383Trp Uncertain significance Single submitter
- KCNK10 p.Arg412Cys Uncertain significance Single submitter
- KCNK10 p.Arg47Cys Uncertain significance Single submitter
- KCNK10 p.Arg47His Uncertain significance Single submitter
- KCNK10 p.Arg482Gln Uncertain significance Single submitter
- KCNK10 p.Arg482Trp Uncertain significance Single submitter
- KCNK10 p.Arg531Trp Uncertain significance Single submitter
- KCNK10 p.Asn351Ser Uncertain significance Single submitter
- KCNK10 p.Asn500Asp Uncertain significance Single submitter
- KCNK10 p.Asp465Glu Uncertain significance Single submitter
- KCNK10 p.Glu299Asp Uncertain significance Single submitter
- KCNK10 p.Glu488Lys Uncertain significance Single submitter
- KCNK10 p.Glu489Asp Uncertain significance Single submitter
- KCNK10 p.Gly411Ser Uncertain significance Single submitter
- KCNK10 p.His135Arg Uncertain significance Single submitter
- KCNK10 p.His439Pro Uncertain significance Single submitter
- KCNK10 p.His439Tyr Uncertain significance Single submitter
- KCNK10 p.Ile147Val Uncertain significance Single submitter
- KCNK10 p.Leu98Ser Uncertain significance Single submitter
- KCNK10 p.Lys438Arg Uncertain significance Single submitter
- KCNK10 p.Lys491Thr Uncertain significance Single submitter
- KCNK10 p.Met523Thr Uncertain significance Single submitter
- KCNK10 p.Pro126Leu Uncertain significance Single submitter
- KCNK10 p.Pro25Arg Uncertain significance Single submitter
- KCNK10 p.Pro40Leu Uncertain significance Single submitter
- KCNK10 p.Ser31Asn Uncertain significance Single submitter
- KCNK10 p.Thr33Ala Uncertain significance Single submitter
- KCNK10 p.Thr43Ala Uncertain significance Single submitter
- KCNK10 p.Thr480Ile Uncertain significance Single submitter
- KCNK10 p.Thr526Met Uncertain significance Single submitter
- KCNK10 p.Thr76Met Uncertain significance Single submitter
- KCNK10 p.Thr90Ile Uncertain significance Single submitter
- KCNK10 p.Tyr315Cys Uncertain significance Single submitter
- KCNK10 p.Val20Ile Uncertain significance Single submitter
- KCNK10 p.Val57Ala Uncertain significance Single submitter
- KCNK10 p.Val78Leu Uncertain significance Single submitter
- KCNK10 p.Val94Phe Uncertain significance Single submitter
Predictors split 15
The independent predictors disagree with each other — read with care.
- KCNK10 p.Ala350Val Uncertain significance Single submitter
- KCNK10 p.Arg119Trp Uncertain significance Single submitter
- KCNK10 p.Arg360Gln Uncertain significance Single submitter
- KCNK10 p.Arg373Leu Uncertain significance Single submitter
- KCNK10 p.Arg378His Uncertain significance Single submitter
- KCNK10 p.Arg378Leu Uncertain significance Single submitter
- KCNK10 p.Arg383Gly Uncertain significance Single submitter
- KCNK10 p.Arg96Trp Uncertain significance Single submitter
- KCNK10 p.Asp369Glu Uncertain significance Single submitter
- KCNK10 p.Asp369Gly Uncertain significance Single submitter
- KCNK10 p.Lys114Gln Uncertain significance Single submitter
- KCNK10 p.Lys186Glu Uncertain significance Single submitter
- KCNK10 p.Lys217Asn Uncertain significance Single submitter
- KCNK10 p.Val365Leu Uncertain significance Single submitter
-
KCNK10 p.Lys333Asn
Likely benign
No assertion criteria
EBV-positive nodal T- and NK-cell lymphoma
All KCNK10 variants
Benign 1
- c.-17A>C Single submitter
Likely benign 5
- p.Ala19= Single submitter
- p.Asn450= Single submitter
- p.Pro533Leu Single submitter
- p.Thr510= Single submitter
- p.Lys333Asn No assertion criteria EBV-positive nodal T- and NK-cell lymphoma ⚠
Uncertain significance 62
- p.Ala115Val Single submitter ⚠
- p.Ala22Thr Single submitter ⚠
- p.Ala293Ser Single submitter ⚠
- p.Ala293Thr Single submitter ⚠
- p.Ala350Val Single submitter ⚠
- p.Ala41Thr Single submitter ⚠
- p.Arg119Gln Single submitter ⚠
- p.Arg119Trp Single submitter ⚠
- p.Arg360Gln Single submitter ⚠
- p.Arg373Leu Single submitter ⚠
- p.Arg373Trp Single submitter ⚠
- p.Arg378Cys Single submitter ⚠
- p.Arg378His Single submitter ⚠
- p.Arg378Leu Single submitter ⚠
- p.Arg382His Single submitter
- p.Arg383Gly Single submitter ⚠
- p.Arg383Trp Single submitter ⚠
- p.Arg412Cys Single submitter ⚠
- p.Arg47Cys Single submitter ⚠
- p.Arg47His Single submitter ⚠
- p.Arg482Gln Single submitter ⚠
- p.Arg482Trp Single submitter ⚠
- p.Arg531Trp Single submitter ⚠
- p.Arg96Trp Single submitter ⚠
- p.Asn351Ser Single submitter ⚠
- p.Asn500Asp Single submitter ⚠
- p.Asp369Glu Single submitter ⚠
- p.Asp369Gly Single submitter ⚠
- p.Asp465Glu Single submitter ⚠
- p.Glu299Asp Single submitter ⚠
- p.Glu488Lys Single submitter ⚠
- p.Glu489Asp Single submitter ⚠
- p.Gly411Ser Single submitter ⚠
- p.Gly453Arg Single submitter
- p.His135Arg Single submitter ⚠
- p.His439Pro Single submitter ⚠
- p.His439Tyr Single submitter ⚠
- p.Ile147Val Single submitter ⚠
- p.Leu137Phe Single submitter
- p.Leu98Ser Single submitter ⚠
- p.Lys114Gln Single submitter ⚠
- p.Lys186Glu Single submitter ⚠
- p.Lys217Asn Single submitter ⚠
- p.Lys438Arg Single submitter ⚠
- p.Lys491Thr Single submitter ⚠
- p.Met523Thr Single submitter ⚠
- p.Pro126Leu Single submitter ⚠
- p.Pro25Arg Single submitter ⚠
- p.Pro40Leu Single submitter ⚠
- p.Ser31Asn Single submitter ⚠
- p.Thr33Ala Single submitter ⚠
- p.Thr43Ala Single submitter ⚠
- p.Thr480Ile Single submitter ⚠
- p.Thr526Met Single submitter ⚠
- p.Thr76Met Single submitter ⚠
- p.Thr90Ile Single submitter ⚠
- p.Tyr315Cys Single submitter ⚠
- p.Val20Ile Single submitter ⚠
- p.Val365Leu Single submitter ⚠
- p.Val57Ala Single submitter ⚠
- p.Val78Leu Single submitter ⚠
- p.Val94Phe Single submitter ⚠