Sugi Variant

Sugi Variant/KCNK9

KCNK9 — 87 ClinVar variants

All ClinVar germline KCNK9 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 47 flagged for review →

1 Pathogenic · 1 Pathogenic/Likely pathogenic · 5 Likely pathogenic · 2 Conflicting · 6 Benign · 17 Likely benign · 55 Uncertain significance

Full KCNK9 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions

⚑ Evidence disagreements 47

Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.

Predictors agree, ClinVar conflicts 1

ClinVar submitters conflict, but the independent predictors unanimously agree — a QC review flag, not a reclassification.

Predictors lean, ClinVar uncertain 36

ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.

Predictors split 10

The independent predictors disagree with each other — read with care.

All KCNK9 variants

Pathogenic 1

Pathogenic/Likely pathogenic 1

Likely pathogenic 5

Conflicting classifications of pathogenicity 2

Benign 6

Likely benign 17

Uncertain significance 55