KCNMB4 — 19 ClinVar variants
All ClinVar germline KCNMB4 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 17 flagged for review →
19 Uncertain significance
Full KCNMB4 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 17
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 15
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- KCNMB4 p.Ala43Val Uncertain significance Single submitter
- KCNMB4 p.Arg207Cys Uncertain significance Single submitter
- KCNMB4 p.Arg207His Uncertain significance Single submitter
- KCNMB4 p.Asn53Ser Uncertain significance Single submitter
- KCNMB4 p.Asp103Asn Uncertain significance Single submitter
- KCNMB4 p.His105Arg Uncertain significance Single submitter
- KCNMB4 p.His162Arg Uncertain significance Single submitter
- KCNMB4 p.Ile192Val Uncertain significance Single submitter
- KCNMB4 p.Ile26Val Uncertain significance Single submitter
- KCNMB4 p.Ile34Ser Uncertain significance Single submitter
- KCNMB4 p.Thr147Ile Uncertain significance Single submitter
- KCNMB4 p.Thr50Ala Uncertain significance Single submitter
- KCNMB4 p.Tyr8Ser Uncertain significance Single submitter
- KCNMB4 p.Val185Phe Uncertain significance Single submitter
- KCNMB4 p.Val6Leu Uncertain significance Single submitter
Predictors split 2
The independent predictors disagree with each other — read with care.
All KCNMB4 variants
Uncertain significance 19
- p.Ala43Val Single submitter ⚠
- p.Arg207Cys Single submitter ⚠
- p.Arg207His Single submitter ⚠
- p.Asn53Ser Single submitter ⚠
- p.Asp103Asn Single submitter ⚠
- p.Glu104Gly Single submitter ⚠
- p.Glu93Ter Single submitter
- p.His105Arg Single submitter ⚠
- p.His162Arg Single submitter ⚠
- p.Ile192Val Single submitter ⚠
- p.Ile26Val Single submitter ⚠
- p.Ile34Ser Single submitter ⚠
- p.Lys195Asn Single submitter ⚠
- p.Pro42Arg Single submitter
- p.Thr147Ile Single submitter ⚠
- p.Thr50Ala Single submitter ⚠
- p.Tyr8Ser Single submitter ⚠
- p.Val185Phe Single submitter ⚠
- p.Val6Leu Single submitter ⚠