KDM1B — 66 ClinVar variants
All ClinVar germline KDM1B variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 59 flagged for review →
1 Benign · 1 Benign/Likely benign · 1 Likely benign · 63 Uncertain significance
Full KDM1B gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 59
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 49
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- KDM1B p.Gly715Arg Uncertain significance Multiple submitters
- KDM1B p.Ala30Val Uncertain significance Single submitter
- KDM1B p.Ala413Asp Uncertain significance Single submitter
- KDM1B p.Ala821Thr Uncertain significance Single submitter
- KDM1B p.Arg358Lys Uncertain significance Single submitter
- KDM1B p.Arg691Gln Uncertain significance Single submitter
- KDM1B p.Arg738Trp Uncertain significance Single submitter
- KDM1B p.Arg7Thr Uncertain significance Single submitter
- KDM1B p.Asn440Ser Uncertain significance Single submitter
- KDM1B p.Asp372Asn Uncertain significance Single submitter
- KDM1B p.Asp725Gly Uncertain significance Single submitter
- KDM1B p.Cys147Ser Uncertain significance Single submitter
- KDM1B p.Gln134Arg Uncertain significance Single submitter
- KDM1B p.Gln731Arg Uncertain significance Single submitter
- KDM1B p.Gly27Ala Uncertain significance Single submitter
- KDM1B p.Gly617Arg Uncertain significance Single submitter
- KDM1B p.Gly773Arg Uncertain significance Single submitter
- KDM1B p.His334Gln Uncertain significance Single submitter
- KDM1B p.His402Tyr Uncertain significance Single submitter
- KDM1B p.His84Tyr Uncertain significance Single submitter
- KDM1B p.Ile332Met Uncertain significance Single submitter
- KDM1B p.Ile362Leu Uncertain significance Single submitter
- KDM1B p.Ile662Val Uncertain significance Single submitter
- KDM1B p.Leu375Ile Uncertain significance Single submitter
- KDM1B p.Leu376Phe Uncertain significance Single submitter
- KDM1B p.Leu632Gln Uncertain significance Single submitter
- KDM1B p.Leu664Ser Uncertain significance Single submitter
- KDM1B p.Lys414Gln Uncertain significance Single submitter
- KDM1B p.Lys634Thr Uncertain significance Single submitter
- KDM1B p.Lys742Arg Uncertain significance Single submitter
- KDM1B p.Met356Thr Uncertain significance Single submitter
- KDM1B p.Phe741Leu Uncertain significance Single submitter
- KDM1B p.Pro392Ala Uncertain significance Single submitter
- KDM1B p.Pro641Thr Uncertain significance Single submitter
- KDM1B p.Pro702Leu Uncertain significance Single submitter
- KDM1B p.Ser119Gly Uncertain significance Single submitter
- KDM1B p.Ser687Asn Uncertain significance Single submitter
- KDM1B p.Thr37Ala Uncertain significance Single submitter
- KDM1B p.Thr736Met Uncertain significance Single submitter
- KDM1B p.Thr750Lys Uncertain significance Single submitter
- KDM1B p.Thr759Ile Uncertain significance Single submitter
- KDM1B p.Tyr354Cys Uncertain significance Single submitter
- KDM1B p.Tyr374Cys Uncertain significance Single submitter
- KDM1B p.Val140Ala Uncertain significance Single submitter
- KDM1B p.Val337Ile Uncertain significance Single submitter
- KDM1B p.Val346Ile Uncertain significance Single submitter
- KDM1B p.Val408Met Uncertain significance Single submitter
- KDM1B p.Val608Leu Uncertain significance Single submitter
- KDM1B p.Val813Ile Uncertain significance Single submitter
Predictors split 10
The independent predictors disagree with each other — read with care.
- KDM1B p.Arg738Gln Uncertain significance Single submitter
- KDM1B p.Arg756Trp Uncertain significance Single submitter
- KDM1B p.Ile386Met Uncertain significance Single submitter
- KDM1B p.Leu159Phe Uncertain significance Single submitter
- KDM1B p.Lys115Asn Uncertain significance Single submitter
- KDM1B p.Ser580Leu Uncertain significance Single submitter
- KDM1B p.Ser817Asn Uncertain significance Single submitter
- KDM1B p.Trp762Cys Uncertain significance Single submitter
- KDM1B p.Val623Ala Uncertain significance Single submitter
- KDM1B p.Val729Ala Uncertain significance Single submitter
All KDM1B variants
Benign 1
- c.2233-8G>C Single submitter
Benign/Likely benign 1
- p.Thr35Ile Multiple submitters
Likely benign 1
- p.Ala714= Single submitter
Uncertain significance 63
- p.Gly715Arg Multiple submitters ⚠
- p.Ala30Val Single submitter ⚠
- p.Ala413Asp Single submitter ⚠
- p.Ala821Thr Single submitter ⚠
- p.Arg358Lys Single submitter ⚠
- p.Arg691Gln Single submitter ⚠
- p.Arg738Gln Single submitter ⚠
- p.Arg738Trp Single submitter ⚠
- p.Arg756Trp Single submitter ⚠
- p.Arg7Thr Single submitter ⚠
- p.Asn440Ser Single submitter ⚠
- p.Asp372Asn Single submitter ⚠
- p.Asp725Gly Single submitter ⚠
- p.Cys147Ser Single submitter ⚠
- p.Gln134Arg Single submitter ⚠
- p.Gln453Glu Single submitter
- p.Gln731Arg Single submitter ⚠
- p.Gly170Val Single submitter
- p.Gly27Ala Single submitter ⚠
- p.Gly617Arg Single submitter ⚠
- p.Gly773Arg Single submitter ⚠
- p.His334Gln Single submitter ⚠
- p.His402Tyr Single submitter ⚠
- p.His84Tyr Single submitter ⚠
- p.Ile332Met Single submitter ⚠
- p.Ile362Leu Single submitter ⚠
- p.Ile386Met Single submitter ⚠
- p.Ile662Val Single submitter ⚠
- p.Ile782Thr Single submitter
- p.Leu159Phe Single submitter ⚠
- p.Leu375Ile Single submitter ⚠
- p.Leu376Phe Single submitter ⚠
- p.Leu632Gln Single submitter ⚠
- p.Leu664Ser Single submitter ⚠
- p.Lys115Asn Single submitter ⚠
- p.Lys414Gln Single submitter ⚠
- p.Lys634Thr Single submitter ⚠
- p.Lys742Arg Single submitter ⚠
- p.Met356Thr Single submitter ⚠
- p.Phe741Leu Single submitter ⚠
- p.Pro392Ala Single submitter ⚠
- p.Pro641Thr Single submitter ⚠
- p.Pro702Leu Single submitter ⚠
- p.Ser119Gly Single submitter ⚠
- p.Ser580Leu Single submitter ⚠
- p.Ser687Asn Single submitter ⚠
- p.Ser817Asn Single submitter ⚠
- p.Thr37Ala Single submitter ⚠
- p.Thr736Met Single submitter ⚠
- p.Thr750Lys Single submitter ⚠
- p.Thr759Ile Single submitter ⚠
- p.Thr789Pro Single submitter
- p.Trp762Cys Single submitter ⚠
- p.Tyr354Cys Single submitter ⚠
- p.Tyr374Cys Single submitter ⚠
- p.Val140Ala Single submitter ⚠
- p.Val337Ile Single submitter ⚠
- p.Val346Ile Single submitter ⚠
- p.Val408Met Single submitter ⚠
- p.Val608Leu Single submitter ⚠
- p.Val623Ala Single submitter ⚠
- p.Val729Ala Single submitter ⚠
- p.Val813Ile Single submitter ⚠