Sugi Variant

Sugi Variant/KDM3B

KDM3B — 469 ClinVar variants

All ClinVar germline KDM3B variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 296 flagged for review →

24 Pathogenic · 2 Pathogenic/Likely pathogenic · 21 Likely pathogenic · 11 Conflicting · 16 Benign · 4 Benign/Likely benign · 82 Likely benign · 309 Uncertain significance

Full KDM3B gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions

⚑ Evidence disagreements 296

Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.

Predictors vs ClinVar 2

ClinVar calls these pathogenic, but the computational predictors lean tolerated — the highest-value review flag.

Predictors agree, ClinVar conflicts 7

ClinVar submitters conflict, but the independent predictors unanimously agree — a QC review flag, not a reclassification.

Predictors lean, ClinVar uncertain 209

ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification. · showing the 150 best-reviewed of 209

Predictors split 78

The independent predictors disagree with each other — read with care.

All KDM3B variants

Pathogenic 24

Pathogenic/Likely pathogenic 2

Likely pathogenic 21

Conflicting classifications of pathogenicity 11

Benign 16

Benign/Likely benign 4

Likely benign 82

Uncertain significance 309

Showing the top 300 by review status; the full set is in the sitemap.