KDM4A — 118 ClinVar variants
All ClinVar germline KDM4A variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 100 flagged for review →
6 Benign · 6 Likely benign · 106 Uncertain significance
Full KDM4A gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 100
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 90
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- KDM4A p.Ala567Thr Uncertain significance Single submitter
- KDM4A p.Ala577Thr Uncertain significance Single submitter
- KDM4A p.Ala892Val Uncertain significance Single submitter
- KDM4A p.Ala895Thr Uncertain significance Single submitter
- KDM4A p.Ala901Thr Uncertain significance Single submitter
- KDM4A p.Arg119Gly Uncertain significance Single submitter
- KDM4A p.Arg119Trp Uncertain significance Single submitter
- KDM4A p.Arg152Gln Uncertain significance Single submitter
- KDM4A p.Arg218Trp Uncertain significance Single submitter
- KDM4A p.Arg221His Uncertain significance Single submitter
- KDM4A p.Arg25Gln Uncertain significance Single submitter
- KDM4A p.Arg294Cys Uncertain significance Single submitter
- KDM4A p.Arg393Gln Uncertain significance Single submitter
- KDM4A p.Arg41Trp Uncertain significance Single submitter
- KDM4A p.Arg445Gln Uncertain significance Single submitter
- KDM4A p.Arg445Trp Uncertain significance Single submitter
- KDM4A p.Arg498Cys Uncertain significance Single submitter
- KDM4A p.Arg498His Uncertain significance Single submitter
- KDM4A p.Arg498Ser Uncertain significance Single submitter
- KDM4A p.Arg518Trp Uncertain significance Single submitter
- KDM4A p.Arg596Cys Uncertain significance Single submitter
- KDM4A p.Arg597His Uncertain significance Single submitter
- KDM4A p.Arg605His Uncertain significance Single submitter
- KDM4A p.Arg744Gln Uncertain significance Single submitter
- KDM4A p.Arg837Lys Uncertain significance Single submitter
- KDM4A p.Arg891His Uncertain significance Single submitter
- KDM4A p.Arg921Met Uncertain significance Single submitter
- KDM4A p.Asn128Ser Uncertain significance Single submitter
- KDM4A p.Asn26Lys Uncertain significance Single submitter
- KDM4A p.Asn365Ser Uncertain significance Single submitter
- KDM4A p.Asn721Ser Uncertain significance Single submitter
- KDM4A p.Asn809Ser Uncertain significance Single submitter
- KDM4A p.Asp476Tyr Uncertain significance Single submitter
- KDM4A p.Asp524Ala Uncertain significance Single submitter
- KDM4A p.Cys776Tyr Uncertain significance Single submitter
- KDM4A p.Gln407Arg Uncertain significance Single submitter
- KDM4A p.Gln446Pro Uncertain significance Single submitter
- KDM4A p.Gln700Arg Uncertain significance Single submitter
- KDM4A p.Glu1034Gln Uncertain significance Single submitter
- KDM4A p.Glu366Asp Uncertain significance Single submitter
- KDM4A p.Glu448Asp Uncertain significance Single submitter
- KDM4A p.Glu529Lys Uncertain significance Single submitter
- KDM4A p.Glu558Lys Uncertain significance Single submitter
- KDM4A p.Glu589Gly Uncertain significance Single submitter
- KDM4A p.Glu812Asp Uncertain significance Single submitter
- KDM4A p.Gly497Glu Uncertain significance Single submitter
- KDM4A p.Gly503Cys Uncertain significance Single submitter
- KDM4A p.Gly683Ala Uncertain significance Single submitter
- KDM4A p.Gly684Ser Uncertain significance Single submitter
- KDM4A p.Gly894Glu Uncertain significance Single submitter
- KDM4A p.Gly912Arg Uncertain significance Single submitter
- KDM4A p.Gly974Ala Uncertain significance Single submitter
- KDM4A p.His144Arg Uncertain significance Single submitter
- KDM4A p.His343Arg Uncertain significance Single submitter
- KDM4A p.Ile521Leu Uncertain significance Single submitter
- KDM4A p.Ile831Asn Uncertain significance Single submitter
- KDM4A p.Leu176Val Uncertain significance Single submitter
- KDM4A p.Leu695Val Uncertain significance Single submitter
- KDM4A p.Lys591Arg Uncertain significance Single submitter
- KDM4A p.Lys756Asn Uncertain significance Single submitter
- KDM4A p.Met15Thr Uncertain significance Single submitter
- KDM4A p.Met374Thr Uncertain significance Single submitter
- KDM4A p.Phe127Leu Uncertain significance Single submitter
- KDM4A p.Phe24Leu Uncertain significance Single submitter
- KDM4A p.Phe464Ile Uncertain significance Single submitter
- KDM4A p.Pro492Arg Uncertain significance Single submitter
- KDM4A p.Pro559Leu Uncertain significance Single submitter
- KDM4A p.Pro649Leu Uncertain significance Single submitter
- KDM4A p.Pro753Leu Uncertain significance Single submitter
- KDM4A p.Pro754Leu Uncertain significance Single submitter
- KDM4A p.Ser210Thr Uncertain significance Single submitter
- KDM4A p.Ser357Gly Uncertain significance Single submitter
- KDM4A p.Ser457Pro Uncertain significance Single submitter
- KDM4A p.Ser508Pro Uncertain significance Single submitter
- KDM4A p.Ser523Ala Uncertain significance Single submitter
- KDM4A p.Ser532Pro Uncertain significance Single submitter
- KDM4A p.Ser767Leu Uncertain significance Single submitter
- KDM4A p.Thr126Lys Uncertain significance Single submitter
- KDM4A p.Thr189Ser Uncertain significance Single submitter
- KDM4A p.Thr428Met Uncertain significance Single submitter
- KDM4A p.Thr539Met Uncertain significance Single submitter
- KDM4A p.Thr625Ile Uncertain significance Single submitter
- KDM4A p.Thr718Met Uncertain significance Single submitter
- KDM4A p.Thr900Ser Uncertain significance Single submitter
- KDM4A p.Thr924Ala Uncertain significance Single submitter
- KDM4A p.Val304Leu Uncertain significance Single submitter
- KDM4A p.Val736Ile Uncertain significance Single submitter
- KDM4A p.Val743Ile Uncertain significance Single submitter
- KDM4A p.Val818Met Uncertain significance Single submitter
- KDM4A p.Val845Ala Uncertain significance Single submitter
Predictors split 10
The independent predictors disagree with each other — read with care.
- KDM4A p.Arg152Trp Uncertain significance Single submitter
- KDM4A p.Arg328Gly Uncertain significance Single submitter
- KDM4A p.Arg41Gln Uncertain significance Single submitter
- KDM4A p.Gln964His Uncertain significance Single submitter
- KDM4A p.Gly731Asp Uncertain significance Single submitter
- KDM4A p.Lys89Arg Uncertain significance Single submitter
- KDM4A p.Lys904Glu Uncertain significance Single submitter
- KDM4A p.Pro406Leu Uncertain significance Single submitter
- KDM4A p.Pro608Gln Uncertain significance Single submitter
- KDM4A p.Thr926Asn Uncertain significance Single submitter
All KDM4A variants
Benign 6
- c.2961+10G>A Multiple submitters
- p.Ala493= Multiple submitters
- p.Met374Val Multiple submitters
- p.Pro10= Multiple submitters
- p.Thr16= Multiple submitters
- p.Thr76= Multiple submitters
Likely benign 6
- p.Ala568Thr Single submitter
- p.Arg518Gln Single submitter
- p.Arg534Gln Single submitter
- p.Arg792= Single submitter
- p.Gly974= Single submitter
- p.Pro431= Single submitter
Uncertain significance 106
- p.Ala567Thr Single submitter ⚠
- p.Ala577Thr Single submitter ⚠
- p.Ala892Val Single submitter ⚠
- p.Ala895Thr Single submitter ⚠
- p.Ala901Thr Single submitter ⚠
- p.Arg119Gly Single submitter ⚠
- p.Arg119Trp Single submitter ⚠
- p.Arg152Gln Single submitter ⚠
- p.Arg152Trp Single submitter ⚠
- p.Arg218Trp Single submitter ⚠
- p.Arg221His Single submitter ⚠
- p.Arg25Gln Single submitter ⚠
- p.Arg294Cys Single submitter ⚠
- p.Arg328Gly Single submitter ⚠
- p.Arg393Gln Single submitter ⚠
- p.Arg41Gln Single submitter ⚠
- p.Arg41Trp Single submitter ⚠
- p.Arg445Gln Single submitter ⚠
- p.Arg445Trp Single submitter ⚠
- p.Arg498Cys Single submitter ⚠
- p.Arg498His Single submitter ⚠
- p.Arg498Ser Single submitter ⚠
- p.Arg518Trp Single submitter ⚠
- p.Arg596Cys Single submitter ⚠
- p.Arg597His Single submitter ⚠
- p.Arg605His Single submitter ⚠
- p.Arg744Gln Single submitter ⚠
- p.Arg781Ter Single submitter
- p.Arg837Lys Single submitter ⚠
- p.Arg891His Single submitter ⚠
- p.Arg921Met Single submitter ⚠
- p.Asn128Ser Single submitter ⚠
- p.Asn26Lys Single submitter ⚠
- p.Asn365Ser Single submitter ⚠
- p.Asn721Ser Single submitter ⚠
- p.Asn809Ser Single submitter ⚠
- p.Asn931Thr Single submitter
- p.Asp476Tyr Single submitter ⚠
- p.Asp524Ala Single submitter ⚠
- p.Cys776Tyr Single submitter ⚠
- p.Gln407Arg Single submitter ⚠
- p.Gln446Pro Single submitter ⚠
- p.Gln700Arg Single submitter ⚠
- p.Gln964His Single submitter ⚠
- p.Glu1034Gln Single submitter ⚠
- p.Glu366Asp Single submitter ⚠
- p.Glu408Val Single submitter
- p.Glu448Asp Single submitter ⚠
- p.Glu529Lys Single submitter ⚠
- p.Glu558Lys Single submitter ⚠
- p.Glu589Gly Single submitter ⚠
- p.Glu812Asp Single submitter ⚠
- p.Gly497Glu Single submitter ⚠
- p.Gly503Cys Single submitter ⚠
- p.Gly683Ala Single submitter ⚠
- p.Gly684Ser Single submitter ⚠
- p.Gly731Asp Single submitter ⚠
- p.Gly894Glu Single submitter ⚠
- p.Gly912Arg Single submitter ⚠
- p.Gly974Ala Single submitter ⚠
- p.His144Arg Single submitter ⚠
- p.His343Arg Single submitter ⚠
- p.Ile341Thr Single submitter
- p.Ile521Leu Single submitter ⚠
- p.Ile62Thr Single submitter
- p.Ile831Asn Single submitter ⚠
- p.Leu176Val Single submitter ⚠
- p.Leu695Val Single submitter ⚠
- p.Lys301Arg Single submitter
- p.Lys591Arg Single submitter ⚠
- p.Lys756Asn Single submitter ⚠
- p.Lys89Arg Single submitter ⚠
- p.Lys904Glu Single submitter ⚠
- p.Met15Thr Single submitter ⚠
- p.Met374Thr Single submitter ⚠
- p.Phe127Leu Single submitter ⚠
- p.Phe24Leu Single submitter ⚠
- p.Phe464Ile Single submitter ⚠
- p.Pro406Leu Single submitter ⚠
- p.Pro492Arg Single submitter ⚠
- p.Pro559Leu Single submitter ⚠
- p.Pro608Gln Single submitter ⚠
- p.Pro649Leu Single submitter ⚠
- p.Pro753Leu Single submitter ⚠
- p.Pro754Leu Single submitter ⚠
- p.Ser210Thr Single submitter ⚠
- p.Ser357Gly Single submitter ⚠
- p.Ser457Pro Single submitter ⚠
- p.Ser508Pro Single submitter ⚠
- p.Ser523Ala Single submitter ⚠
- p.Ser532Pro Single submitter ⚠
- p.Ser767Leu Single submitter ⚠
- p.Thr126Lys Single submitter ⚠
- p.Thr189Ser Single submitter ⚠
- p.Thr428Met Single submitter ⚠
- p.Thr539Met Single submitter ⚠
- p.Thr625Ile Single submitter ⚠
- p.Thr718Met Single submitter ⚠
- p.Thr900Ser Single submitter ⚠
- p.Thr924Ala Single submitter ⚠
- p.Thr926Asn Single submitter ⚠
- p.Val304Leu Single submitter ⚠
- p.Val736Ile Single submitter ⚠
- p.Val743Ile Single submitter ⚠
- p.Val818Met Single submitter ⚠
- p.Val845Ala Single submitter ⚠