KDM4D — 62 ClinVar variants
All ClinVar germline KDM4D variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 59 flagged for review →
2 Benign · 1 Likely benign · 59 Uncertain significance
Full KDM4D gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 59
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 27
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- KDM4D p.Ala315Ser Uncertain significance Single submitter
- KDM4D p.Ala8Ser Uncertain significance Single submitter
- KDM4D p.Arg316Thr Uncertain significance Single submitter
- KDM4D p.Arg368Lys Uncertain significance Single submitter
- KDM4D p.Arg383Gln Uncertain significance Single submitter
- KDM4D p.Arg392Cys Uncertain significance Single submitter
- KDM4D p.Arg392His Uncertain significance Single submitter
- KDM4D p.Arg396Gln Uncertain significance Single submitter
- KDM4D p.Arg407Cys Uncertain significance Single submitter
- KDM4D p.Gly373Asp Uncertain significance Single submitter
- KDM4D p.Gly516Glu Uncertain significance Single submitter
- KDM4D p.Gly99Ala Uncertain significance Single submitter
- KDM4D p.His398Gln Uncertain significance Single submitter
- KDM4D p.Ile327Val Uncertain significance Single submitter
- KDM4D p.Leu405His Uncertain significance Single submitter
- KDM4D p.Leu497Val Uncertain significance Single submitter
- KDM4D p.Pro353Leu Uncertain significance Single submitter
- KDM4D p.Pro378Thr Uncertain significance Single submitter
- KDM4D p.Pro386Ala Uncertain significance Single submitter
- KDM4D p.Pro418Ser Uncertain significance Single submitter
- KDM4D p.Pro511Ser Uncertain significance Single submitter
- KDM4D p.Pro74Leu Uncertain significance Single submitter
- KDM4D p.Ser484Leu Uncertain significance Single submitter
- KDM4D p.Ser67Asn Uncertain significance Single submitter
- KDM4D p.Ser67Gly Uncertain significance Single submitter
- KDM4D p.Thr62Ser Uncertain significance Single submitter
- KDM4D p.Val522Gly Uncertain significance Single submitter
Predictors split 32
The independent predictors disagree with each other — read with care.
- KDM4D p.Arg102Cys Uncertain significance Single submitter
- KDM4D p.Arg225Cys Uncertain significance Single submitter
- KDM4D p.Arg225His Uncertain significance Single submitter
- KDM4D p.Arg236Trp Uncertain significance Single submitter
- KDM4D p.Arg263Leu Uncertain significance Single submitter
- KDM4D p.Arg383Trp Uncertain significance Single submitter
- KDM4D p.Arg396Trp Uncertain significance Single submitter
- KDM4D p.Arg419Trp Uncertain significance Single submitter
- KDM4D p.Arg451Cys Uncertain significance Single submitter
- KDM4D p.Arg453Cys Uncertain significance Single submitter
- KDM4D p.Arg453His Uncertain significance Single submitter
- KDM4D p.Arg455His Uncertain significance Single submitter
- KDM4D p.Arg45Thr Uncertain significance Single submitter
- KDM4D p.Asn257Asp Uncertain significance Single submitter
- KDM4D p.Gly452Val Uncertain significance Single submitter
- KDM4D p.Gly454Cys Uncertain significance Single submitter
- KDM4D p.His156Tyr Uncertain significance Single submitter
- KDM4D p.His219Tyr Uncertain significance Single submitter
- KDM4D p.Leu335Val Uncertain significance Single submitter
- KDM4D p.Leu467Ile Uncertain significance Single submitter
- KDM4D p.Pro216Ala Uncertain significance Single submitter
- KDM4D p.Ser308Cys Uncertain significance Single submitter
- KDM4D p.Ser385Phe Uncertain significance Single submitter
- KDM4D p.Ser409Tyr Uncertain significance Single submitter
- KDM4D p.Ser40Phe Uncertain significance Single submitter
- KDM4D p.Ser435Phe Uncertain significance Single submitter
- KDM4D p.Ser484Trp Uncertain significance Single submitter
- KDM4D p.Thr252Ile Uncertain significance Single submitter
- KDM4D p.Thr416Met Uncertain significance Single submitter
- KDM4D p.Tyr277Cys Uncertain significance Single submitter
- KDM4D p.Val512Ile Uncertain significance Single submitter
- KDM4D p.Val522Met Uncertain significance Single submitter
All KDM4D variants
Benign 2
- p.Ala471Ser Multiple submitters
- p.Ser355Arg Multiple submitters
Likely benign 1
- p.Asn262Ser Single submitter
Uncertain significance 59
- p.Ala315Ser Single submitter ⚠
- p.Ala8Ser Single submitter ⚠
- p.Arg102Cys Single submitter ⚠
- p.Arg225Cys Single submitter ⚠
- p.Arg225His Single submitter ⚠
- p.Arg236Trp Single submitter ⚠
- p.Arg263Leu Single submitter ⚠
- p.Arg316Thr Single submitter ⚠
- p.Arg368Lys Single submitter ⚠
- p.Arg383Gln Single submitter ⚠
- p.Arg383Trp Single submitter ⚠
- p.Arg392Cys Single submitter ⚠
- p.Arg392His Single submitter ⚠
- p.Arg396Gln Single submitter ⚠
- p.Arg396Trp Single submitter ⚠
- p.Arg407Cys Single submitter ⚠
- p.Arg419Trp Single submitter ⚠
- p.Arg451Cys Single submitter ⚠
- p.Arg453Cys Single submitter ⚠
- p.Arg453His Single submitter ⚠
- p.Arg455His Single submitter ⚠
- p.Arg45Thr Single submitter ⚠
- p.Asn257Asp Single submitter ⚠
- p.Gly373Asp Single submitter ⚠
- p.Gly452Val Single submitter ⚠
- p.Gly454Cys Single submitter ⚠
- p.Gly516Glu Single submitter ⚠
- p.Gly99Ala Single submitter ⚠
- p.His156Tyr Single submitter ⚠
- p.His219Tyr Single submitter ⚠
- p.His398Gln Single submitter ⚠
- p.Ile327Val Single submitter ⚠
- p.Leu335Val Single submitter ⚠
- p.Leu405His Single submitter ⚠
- p.Leu467Ile Single submitter ⚠
- p.Leu497Val Single submitter ⚠
- p.Pro216Ala Single submitter ⚠
- p.Pro353Leu Single submitter ⚠
- p.Pro378Thr Single submitter ⚠
- p.Pro386Ala Single submitter ⚠
- p.Pro418Ser Single submitter ⚠
- p.Pro511Ser Single submitter ⚠
- p.Pro74Leu Single submitter ⚠
- p.Ser308Cys Single submitter ⚠
- p.Ser385Phe Single submitter ⚠
- p.Ser409Tyr Single submitter ⚠
- p.Ser40Phe Single submitter ⚠
- p.Ser435Phe Single submitter ⚠
- p.Ser484Leu Single submitter ⚠
- p.Ser484Trp Single submitter ⚠
- p.Ser67Asn Single submitter ⚠
- p.Ser67Gly Single submitter ⚠
- p.Thr252Ile Single submitter ⚠
- p.Thr416Met Single submitter ⚠
- p.Thr62Ser Single submitter ⚠
- p.Tyr277Cys Single submitter ⚠
- p.Val512Ile Single submitter ⚠
- p.Val522Gly Single submitter ⚠
- p.Val522Met Single submitter ⚠