KDM4E — 106 ClinVar variants
All ClinVar germline KDM4E variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 100 flagged for review →
2 Benign · 6 Likely benign · 98 Uncertain significance
Full KDM4E gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 100
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 42
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- KDM4E p.Ala224Asp Uncertain significance Single submitter
- KDM4E p.Ala406Thr Uncertain significance Single submitter
- KDM4E p.Arg222Cys Uncertain significance Single submitter
- KDM4E p.Arg222His Uncertain significance Single submitter
- KDM4E p.Arg462Pro Uncertain significance Single submitter
- KDM4E p.Arg484Ser Uncertain significance Single submitter
- KDM4E p.Arg491Ser Uncertain significance Single submitter
- KDM4E p.Asn10Lys Uncertain significance Single submitter
- KDM4E p.Asp319Glu Uncertain significance Single submitter
- KDM4E p.Cys391Tyr Uncertain significance Single submitter
- KDM4E p.Gln337Lys Uncertain significance Single submitter
- KDM4E p.Gln447Lys Uncertain significance Single submitter
- KDM4E p.Glu170Asp Uncertain significance Single submitter
- KDM4E p.Glu170Gln Uncertain significance Single submitter
- KDM4E p.Glu170Lys Uncertain significance Single submitter
- KDM4E p.Glu36Lys Uncertain significance Single submitter
- KDM4E p.Gly234Ser Uncertain significance Single submitter
- KDM4E p.Gly458Ser Uncertain significance Single submitter
- KDM4E p.Gly465Glu Uncertain significance Single submitter
- KDM4E p.Gly80Arg Uncertain significance Single submitter
- KDM4E p.His189Gln Uncertain significance Single submitter
- KDM4E p.His241Gln Uncertain significance Single submitter
- KDM4E p.Ile256Thr Uncertain significance Single submitter
- KDM4E p.Ile256Val Uncertain significance Single submitter
- KDM4E p.Ile341Thr Uncertain significance Single submitter
- KDM4E p.Leu227Phe Uncertain significance Single submitter
- KDM4E p.Leu227Pro Uncertain significance Single submitter
- KDM4E p.Leu355Pro Uncertain significance Single submitter
- KDM4E p.Leu373Ile Uncertain significance Single submitter
- KDM4E p.Lys105Glu Uncertain significance Single submitter
- KDM4E p.Met181Ile Uncertain significance Single submitter
- KDM4E p.Met423Ile Uncertain significance Single submitter
- KDM4E p.Pro127Thr Uncertain significance Single submitter
- KDM4E p.Pro320Arg Uncertain significance Single submitter
- KDM4E p.Ser405Pro Uncertain significance Single submitter
- KDM4E p.Ser424Leu Uncertain significance Single submitter
- KDM4E p.Thr11Met Uncertain significance Single submitter
- KDM4E p.Thr146Ala Uncertain significance Single submitter
- KDM4E p.Thr416Ser Uncertain significance Single submitter
- KDM4E p.Trp149Cys Uncertain significance Single submitter
- KDM4E p.Val471Ala Uncertain significance Single submitter
-
KDM4E p.Asn498Ser
Uncertain significance
No assertion criteria
breast ductal adenocarcinoma
Predictors split 58
The independent predictors disagree with each other — read with care.
- KDM4E p.Ala265Val Uncertain significance Single submitter
- KDM4E p.Ala287Thr Uncertain significance Single submitter
- KDM4E p.Arg100Cys Uncertain significance Single submitter
- KDM4E p.Arg121Pro Uncertain significance Single submitter
- KDM4E p.Arg296Gln Uncertain significance Single submitter
- KDM4E p.Arg323Cys Uncertain significance Single submitter
- KDM4E p.Arg443Cys Uncertain significance Single submitter
- KDM4E p.Arg443His Uncertain significance Single submitter
- KDM4E p.Arg453Cys Uncertain significance Single submitter
- KDM4E p.Arg455His Uncertain significance Single submitter
- KDM4E p.Arg478Cys Uncertain significance Single submitter
- KDM4E p.Arg478His Uncertain significance Single submitter
- KDM4E p.Arg99Cys Uncertain significance Single submitter
- KDM4E p.Arg99His Uncertain significance Single submitter
- KDM4E p.Asp61His Uncertain significance Single submitter
- KDM4E p.Gln113His Uncertain significance Single submitter
- KDM4E p.Gln306Glu Uncertain significance Single submitter
- KDM4E p.Gln42Pro Uncertain significance Single submitter
- KDM4E p.Glu119Gly Uncertain significance Single submitter
- KDM4E p.Glu144Gly Uncertain significance Single submitter
- KDM4E p.Glu221Gln Uncertain significance Single submitter
- KDM4E p.Glu267Gly Uncertain significance Single submitter
- KDM4E p.Glu328Lys Uncertain significance Single submitter
- KDM4E p.Gly283Ser Uncertain significance Single submitter
- KDM4E p.Gly370Ser Uncertain significance Single submitter
- KDM4E p.Gly444Asp Uncertain significance Single submitter
- KDM4E p.Gly450Ala Uncertain significance Single submitter
- KDM4E p.Gly454Ala Uncertain significance Single submitter
- KDM4E p.Gly81Asp Uncertain significance Single submitter
- KDM4E p.His344Tyr Uncertain significance Single submitter
- KDM4E p.Ile137Met Uncertain significance Single submitter
- KDM4E p.Ile246Val Uncertain significance Single submitter
- KDM4E p.Ile298Thr Uncertain significance Single submitter
- KDM4E p.Ile66Thr Uncertain significance Single submitter
- KDM4E p.Ile68Val Likely benign Single submitter
- KDM4E p.Leu369Pro Uncertain significance Single submitter
- KDM4E p.Met22Ile Uncertain significance Single submitter
- KDM4E p.Met261Arg Uncertain significance Single submitter
- KDM4E p.Met269Ile Uncertain significance Single submitter
- KDM4E p.Met269Val Uncertain significance Single submitter
- KDM4E p.Phe142Leu Uncertain significance Single submitter
- KDM4E p.Phe18Val Uncertain significance Single submitter
- KDM4E p.Phe203Leu Likely benign Single submitter
- KDM4E p.Pro110Leu Uncertain significance Single submitter
- KDM4E p.Pro111Ser Uncertain significance Single submitter
- KDM4E p.Pro206Ala Uncertain significance Single submitter
- KDM4E p.Pro473Thr Uncertain significance Single submitter
- KDM4E p.Ser140Tyr Uncertain significance Single submitter
- KDM4E p.Ser247Leu Uncertain significance Single submitter
- KDM4E p.Ser452Asn Uncertain significance Single submitter
- KDM4E p.Thr109Ile Uncertain significance Single submitter
- KDM4E p.Thr420Ile Uncertain significance Single submitter
- KDM4E p.Thr432Ile Uncertain significance Single submitter
- KDM4E p.Thr70Ile Uncertain significance Single submitter
- KDM4E p.Tyr98His Uncertain significance Single submitter
- KDM4E p.Val212Met Uncertain significance Single submitter
- KDM4E p.Val471Phe Uncertain significance Single submitter
- KDM4E p.Val95Glu Uncertain significance Single submitter
All KDM4E variants
Benign 2
- p.Cys381Tyr Multiple submitters
- p.Gln42Arg Multiple submitters
Likely benign 6
- p.Ala187= Multiple submitters
- p.Thr190= Multiple submitters
- p.Ile68Val Single submitter ⚠
- p.Phe203Leu Single submitter ⚠
- p.Pro495= Single submitter
- p.Val386= Single submitter
Uncertain significance 98
- p.Ala224Asp Single submitter ⚠
- p.Ala265Val Single submitter ⚠
- p.Ala287Thr Single submitter ⚠
- p.Ala406Thr Single submitter ⚠
- p.Arg100Cys Single submitter ⚠
- p.Arg121Pro Single submitter ⚠
- p.Arg222Cys Single submitter ⚠
- p.Arg222His Single submitter ⚠
- p.Arg296Gln Single submitter ⚠
- p.Arg323Cys Single submitter ⚠
- p.Arg443Cys Single submitter ⚠
- p.Arg443His Single submitter ⚠
- p.Arg453Cys Single submitter ⚠
- p.Arg455His Single submitter ⚠
- p.Arg462Pro Single submitter ⚠
- p.Arg478Cys Single submitter ⚠
- p.Arg478His Single submitter ⚠
- p.Arg484Ser Single submitter ⚠
- p.Arg491Ser Single submitter ⚠
- p.Arg99Cys Single submitter ⚠
- p.Arg99His Single submitter ⚠
- p.Asn10Lys Single submitter ⚠
- p.Asp319Glu Single submitter ⚠
- p.Asp61His Single submitter ⚠
- p.Cys391Tyr Single submitter ⚠
- p.Gln113His Single submitter ⚠
- p.Gln306Glu Single submitter ⚠
- p.Gln337Lys Single submitter ⚠
- p.Gln42Pro Single submitter ⚠
- p.Gln447Lys Single submitter ⚠
- p.Glu119Gly Single submitter ⚠
- p.Glu144Gly Single submitter ⚠
- p.Glu170Asp Single submitter ⚠
- p.Glu170Gln Single submitter ⚠
- p.Glu170Lys Single submitter ⚠
- p.Glu221Gln Single submitter ⚠
- p.Glu267Gly Single submitter ⚠
- p.Glu328Lys Single submitter ⚠
- p.Glu36Lys Single submitter ⚠
- p.Gly234Ser Single submitter ⚠
- p.Gly283Ser Single submitter ⚠
- p.Gly370Ser Single submitter ⚠
- p.Gly444Asp Single submitter ⚠
- p.Gly450Ala Single submitter ⚠
- p.Gly454Ala Single submitter ⚠
- p.Gly458Ser Single submitter ⚠
- p.Gly465Glu Single submitter ⚠
- p.Gly80Arg Single submitter ⚠
- p.Gly81Asp Single submitter ⚠
- p.His189Gln Single submitter ⚠
- p.His241Gln Single submitter ⚠
- p.His344Tyr Single submitter ⚠
- p.Ile137Met Single submitter ⚠
- p.Ile246Val Single submitter ⚠
- p.Ile256Thr Single submitter ⚠
- p.Ile256Val Single submitter ⚠
- p.Ile298Thr Single submitter ⚠
- p.Ile341Thr Single submitter ⚠
- p.Ile66Thr Single submitter ⚠
- p.Leu227Phe Single submitter ⚠
- p.Leu227Pro Single submitter ⚠
- p.Leu355Pro Single submitter ⚠
- p.Leu369Pro Single submitter ⚠
- p.Leu373Ile Single submitter ⚠
- p.Lys105Glu Single submitter ⚠
- p.Met181Ile Single submitter ⚠
- p.Met22Ile Single submitter ⚠
- p.Met261Arg Single submitter ⚠
- p.Met269Ile Single submitter ⚠
- p.Met269Val Single submitter ⚠
- p.Met423Ile Single submitter ⚠
- p.Phe142Leu Single submitter ⚠
- p.Phe18Val Single submitter ⚠
- p.Pro110Leu Single submitter ⚠
- p.Pro111Ser Single submitter ⚠
- p.Pro127Thr Single submitter ⚠
- p.Pro206Ala Single submitter ⚠
- p.Pro320Arg Single submitter ⚠
- p.Pro473Thr Single submitter ⚠
- p.Ser140Tyr Single submitter ⚠
- p.Ser247Leu Single submitter ⚠
- p.Ser405Pro Single submitter ⚠
- p.Ser424Leu Single submitter ⚠
- p.Ser452Asn Single submitter ⚠
- p.Thr109Ile Single submitter ⚠
- p.Thr11Met Single submitter ⚠
- p.Thr146Ala Single submitter ⚠
- p.Thr416Ser Single submitter ⚠
- p.Thr420Ile Single submitter ⚠
- p.Thr432Ile Single submitter ⚠
- p.Thr70Ile Single submitter ⚠
- p.Trp149Cys Single submitter ⚠
- p.Tyr98His Single submitter ⚠
- p.Val212Met Single submitter ⚠
- p.Val471Ala Single submitter ⚠
- p.Val471Phe Single submitter ⚠
- p.Val95Glu Single submitter ⚠
- p.Asn498Ser No assertion criteria breast ductal adenocarcinoma ⚠