KDM7A — 89 ClinVar variants
All ClinVar germline KDM7A variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 86 flagged for review →
1 Likely benign · 88 Uncertain significance
Full KDM7A gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 86
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 71
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- KDM7A p.Ala14Gly Uncertain significance Single submitter
- KDM7A p.Ala572Val Uncertain significance Single submitter
- KDM7A p.Ala5Val Uncertain significance Single submitter
- KDM7A p.Ala671Val Uncertain significance Single submitter
- KDM7A p.Ala868Val Uncertain significance Single submitter
- KDM7A p.Arg129Gly Uncertain significance Single submitter
- KDM7A p.Arg184Cys Uncertain significance Single submitter
- KDM7A p.Arg184His Uncertain significance Single submitter
- KDM7A p.Arg418Thr Uncertain significance Single submitter
- KDM7A p.Arg473Gln Uncertain significance Single submitter
- KDM7A p.Arg512Lys Uncertain significance Single submitter
- KDM7A p.Arg515Gln Uncertain significance Single submitter
- KDM7A p.Arg520Gln Uncertain significance Single submitter
- KDM7A p.Arg644His Uncertain significance Single submitter
- KDM7A p.Arg704Lys Uncertain significance Single submitter
- KDM7A p.Arg823Gly Uncertain significance Single submitter
- KDM7A p.Arg839Met Uncertain significance Single submitter
- KDM7A p.Asn372Ser Uncertain significance Single submitter
- KDM7A p.Asn518Ser Uncertain significance Single submitter
- KDM7A p.Asn84Asp Uncertain significance Single submitter
- KDM7A p.Asn84Ser Uncertain significance Single submitter
- KDM7A p.Asn863Lys Uncertain significance Single submitter
- KDM7A p.Asp135Asn Uncertain significance Single submitter
- KDM7A p.Asp157His Uncertain significance Single submitter
- KDM7A p.Asp243His Uncertain significance Single submitter
- KDM7A p.Asp280Asn Uncertain significance Single submitter
- KDM7A p.Asp457Glu Uncertain significance Single submitter
- KDM7A p.Asp686His Uncertain significance Single submitter
- KDM7A p.Asp812His Uncertain significance Single submitter
- KDM7A p.Cys669Ser Uncertain significance Single submitter
- KDM7A p.Gln755Lys Uncertain significance Single submitter
- KDM7A p.Glu309Ala Uncertain significance Single submitter
- KDM7A p.Glu627Gly Uncertain significance Single submitter
- KDM7A p.Glu663Gln Uncertain significance Single submitter
- KDM7A p.Glu717Ala Uncertain significance Single submitter
- KDM7A p.Gly480Asp Uncertain significance Single submitter
- KDM7A p.Gly761Asp Uncertain significance Single submitter
- KDM7A p.Gly850Ser Uncertain significance Single submitter
- KDM7A p.Ile108Asn Uncertain significance Single submitter
- KDM7A p.Leu599Arg Uncertain significance Single submitter
- KDM7A p.Met205Ile Uncertain significance Single submitter
- KDM7A p.Phe327Ser Uncertain significance Single submitter
- KDM7A p.Pro175Ser Uncertain significance Single submitter
- KDM7A p.Pro37Ser Uncertain significance Single submitter
- KDM7A p.Pro489His Uncertain significance Single submitter
- KDM7A p.Pro725Ser Uncertain significance Single submitter
- KDM7A p.Ser604Gly Uncertain significance Single submitter
- KDM7A p.Ser665Cys Uncertain significance Single submitter
- KDM7A p.Ser714Pro Uncertain significance Single submitter
- KDM7A p.Ser747Phe Uncertain significance Single submitter
- KDM7A p.Ser765Phe Uncertain significance Single submitter
- KDM7A p.Ser862Leu Uncertain significance Single submitter
- KDM7A p.Ser875Gly Uncertain significance Single submitter
- KDM7A p.Ser888Leu Uncertain significance Single submitter
- KDM7A p.Ser91Thr Uncertain significance Single submitter
- KDM7A p.Thr106Ala Uncertain significance Single submitter
- KDM7A p.Thr233Ala Uncertain significance Single submitter
- KDM7A p.Thr322Ser Uncertain significance Single submitter
- KDM7A p.Thr426Asn Uncertain significance Single submitter
- KDM7A p.Thr437Ile Uncertain significance Single submitter
- KDM7A p.Thr693Ile Uncertain significance Single submitter
- KDM7A p.Thr728Ala Uncertain significance Single submitter
- KDM7A p.Thr748Lys Uncertain significance Single submitter
- KDM7A p.Thr757Ile Uncertain significance Single submitter
- KDM7A p.Thr813Pro Uncertain significance Single submitter
- KDM7A p.Val158Ile Uncertain significance Single submitter
- KDM7A p.Val239Ala Uncertain significance Single submitter
- KDM7A p.Val494Ala Uncertain significance Single submitter
- KDM7A p.Val519Ile Uncertain significance Single submitter
- KDM7A p.Val629Gly Uncertain significance Single submitter
- KDM7A p.Val8Ala Uncertain significance Single submitter
Predictors split 15
The independent predictors disagree with each other — read with care.
- KDM7A p.Asp47Asn Uncertain significance Single submitter
- KDM7A p.Glu136Lys Uncertain significance Single submitter
- KDM7A p.Gly111Val Uncertain significance Single submitter
- KDM7A p.Gly15Arg Uncertain significance Single submitter
- KDM7A p.Gly64Ser Uncertain significance Single submitter
- KDM7A p.His101Tyr Uncertain significance Single submitter
- KDM7A p.Ile160Met Uncertain significance Single submitter
- KDM7A p.Met235Val Uncertain significance Single submitter
- KDM7A p.Met384Val Uncertain significance Single submitter
- KDM7A p.Pro217Thr Uncertain significance Single submitter
- KDM7A p.Ser22Leu Uncertain significance Single submitter
- KDM7A p.Thr206Ile Uncertain significance Single submitter
- KDM7A p.Thr532Ala Uncertain significance Single submitter
- KDM7A p.Thr920Ala Uncertain significance Single submitter
- KDM7A p.Val186Ala Uncertain significance Single submitter
All KDM7A variants
Likely benign 1
- p.Ser133= Single submitter
Uncertain significance 88
- p.Ala14Gly Single submitter ⚠
- p.Ala572Val Single submitter ⚠
- p.Ala5Val Single submitter ⚠
- p.Ala671Val Single submitter ⚠
- p.Ala868Val Single submitter ⚠
- p.Arg129Gly Single submitter ⚠
- p.Arg184Cys Single submitter ⚠
- p.Arg184His Single submitter ⚠
- p.Arg418Thr Single submitter ⚠
- p.Arg473Gln Single submitter ⚠
- p.Arg512Lys Single submitter ⚠
- p.Arg515Gln Single submitter ⚠
- p.Arg520Gln Single submitter ⚠
- p.Arg644His Single submitter ⚠
- p.Arg704Lys Single submitter ⚠
- p.Arg823Gly Single submitter ⚠
- p.Arg839Met Single submitter ⚠
- p.Asn372Ser Single submitter ⚠
- p.Asn518Ser Single submitter ⚠
- p.Asn84Asp Single submitter ⚠
- p.Asn84Ser Single submitter ⚠
- p.Asn863Lys Single submitter ⚠
- p.Asp135Asn Single submitter ⚠
- p.Asp157His Single submitter ⚠
- p.Asp243His Single submitter ⚠
- p.Asp280Asn Single submitter ⚠
- p.Asp330His Single submitter
- p.Asp457Glu Single submitter ⚠
- p.Asp47Asn Single submitter ⚠
- p.Asp686His Single submitter ⚠
- p.Asp812His Single submitter ⚠
- p.Cys669Ser Single submitter ⚠
- p.Gln755Lys Single submitter ⚠
- p.Glu136Lys Single submitter ⚠
- p.Glu309Ala Single submitter ⚠
- p.Glu627Gly Single submitter ⚠
- p.Glu663Gln Single submitter ⚠
- p.Glu717Ala Single submitter ⚠
- p.Gly111Val Single submitter ⚠
- p.Gly15Arg Single submitter ⚠
- p.Gly480Asp Single submitter ⚠
- p.Gly64Ser Single submitter ⚠
- p.Gly761Asp Single submitter ⚠
- p.Gly850Ser Single submitter ⚠
- p.His101Tyr Single submitter ⚠
- p.Ile108Asn Single submitter ⚠
- p.Ile160Met Single submitter ⚠
- p.Ile77Val Single submitter
- p.Leu599Arg Single submitter ⚠
- p.Met205Ile Single submitter ⚠
- p.Met235Val Single submitter ⚠
- p.Met384Val Single submitter ⚠
- p.Phe327Ser Single submitter ⚠
- p.Pro175Ser Single submitter ⚠
- p.Pro217Thr Single submitter ⚠
- p.Pro37Ser Single submitter ⚠
- p.Pro489His Single submitter ⚠
- p.Pro725Ser Single submitter ⚠
- p.Ser22Leu Single submitter ⚠
- p.Ser604Gly Single submitter ⚠
- p.Ser665Cys Single submitter ⚠
- p.Ser714Pro Single submitter ⚠
- p.Ser747Phe Single submitter ⚠
- p.Ser765Phe Single submitter ⚠
- p.Ser862Leu Single submitter ⚠
- p.Ser875Gly Single submitter ⚠
- p.Ser888Leu Single submitter ⚠
- p.Ser91Thr Single submitter ⚠
- p.Thr106Ala Single submitter ⚠
- p.Thr206Ile Single submitter ⚠
- p.Thr233Ala Single submitter ⚠
- p.Thr322Ser Single submitter ⚠
- p.Thr426Asn Single submitter ⚠
- p.Thr437Ile Single submitter ⚠
- p.Thr532Ala Single submitter ⚠
- p.Thr693Ile Single submitter ⚠
- p.Thr728Ala Single submitter ⚠
- p.Thr748Lys Single submitter ⚠
- p.Thr757Ile Single submitter ⚠
- p.Thr813Pro Single submitter ⚠
- p.Thr920Ala Single submitter ⚠
- p.Val158Ile Single submitter ⚠
- p.Val186Ala Single submitter ⚠
- p.Val239Ala Single submitter ⚠
- p.Val494Ala Single submitter ⚠
- p.Val519Ile Single submitter ⚠
- p.Val629Gly Single submitter ⚠
- p.Val8Ala Single submitter ⚠