KIF15 — 181 ClinVar variants

All ClinVar germline KIF15 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 142 flagged for review →

1 Pathogenic · 2 Likely pathogenic · 1 Conflicting · 13 Benign · 1 Benign/Likely benign · 19 Likely benign · 144 Uncertain significance

Full KIF15 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions

⚑ Evidence disagreements 142

Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.

Predictors agree, ClinVar conflicts 1

ClinVar submitters conflict, but the independent predictors unanimously agree — a QC review flag, not a reclassification.

KIF15 p.Val938Ile Conflicting Single submitter

Predictors lean, ClinVar uncertain 111

ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.

Predictors split 30

The independent predictors disagree with each other — read with care.

All KIF15 variants

Pathogenic 1

p.Arg501Ter No assertion criteria braddock-carey syndrome 2

Likely pathogenic 2

c.1830-2A>C Single submitter braddock-carey syndrome 2
p.Arg804Ter Single submitter braddock-carey syndrome 2

Conflicting classifications of pathogenicity 1

p.Val938Ile Single submitter ⚠

Benign 13

c.2550-6A>G Multiple submitters
c.3049-7T>C Multiple submitters
p.Ala392= Multiple submitters
p.Asn495Asp Multiple submitters
p.Asn827Ser Multiple submitters
p.Asp408Glu Multiple submitters
p.Gln871Glu Multiple submitters
p.Glu1037= Multiple submitters
p.Glu1272Asp Multiple submitters
p.His1147Gln Multiple submitters
p.Leu775= Multiple submitters
p.Ser1083Leu Multiple submitters
c.2278-7C>T Single submitter

Benign/Likely benign 1

p.Ala1375= Multiple submitters

Likely benign 19

p.Ala211Val Multiple submitters
p.Cys162Ser Multiple submitters ⚠
c.1510-9A>G Single submitter
c.3048+9G>A Single submitter
p.Arg1199Cys Single submitter
p.Arg1293= Single submitter
p.Arg501Leu Single submitter
p.Asp487Asn Single submitter
p.Glu829Asp Single submitter
p.Ile253Thr Single submitter
p.Leu589= Single submitter
p.Phe86= Single submitter
p.Ser1083= Single submitter
p.Ser1323Phe Single submitter
p.Thr57= Single submitter
p.Thr71Met Single submitter ⚠
p.Thr826Arg Single submitter
p.Val12= Single submitter
p.Val781= Single submitter

Uncertain significance 144

p.Leu844Val Multiple submitters ⚠
p.Val239Ile Multiple submitters ⚠
p.Ala1136Pro Single submitter ⚠
p.Ala43Thr Single submitter ⚠
p.Ala586Val Single submitter ⚠
p.Ala711Pro Single submitter ⚠
p.Ala810Thr Single submitter ⚠
p.Arg1205Cys Single submitter ⚠
p.Arg1205Leu Single submitter ⚠
p.Arg1293Gln Single submitter ⚠
p.Arg1365Trp Single submitter ⚠
p.Arg1374His Single submitter ⚠
p.Arg138Gln Single submitter ⚠
p.Arg149Cys Single submitter ⚠
p.Arg220Ser Single submitter ⚠
p.Arg223His Single submitter ⚠
p.Arg257Gln Single submitter ⚠
p.Arg290Gln Single submitter ⚠
p.Arg325Trp Single submitter ⚠
p.Arg359Gly Single submitter ⚠
p.Arg386Ser Single submitter ⚠
p.Arg469Cys Single submitter ⚠
p.Arg488His Single submitter ⚠
p.Arg521Gly Single submitter ⚠
p.Arg939His Single submitter ⚠
p.Asn1122Lys Single submitter ⚠
p.Asn1279His Single submitter ⚠
p.Asn127His Single submitter ⚠
p.Asn1340Lys Single submitter ⚠
p.Asn517Ser Single submitter ⚠
p.Asn563Ile Single submitter ⚠
p.Asn596Ser Single submitter ⚠
p.Asn901His Single submitter ⚠
p.Asn913Ser Single submitter ⚠
p.Asp1042Asn Single submitter ⚠
p.Asp1059Asn Single submitter ⚠
p.Asp1059His Single submitter ⚠
p.Asp1165Gly Single submitter ⚠
p.Asp1183Gly Single submitter ⚠
p.Asp1183His Single submitter ⚠
p.Asp25Glu Single submitter ⚠
p.Asp317Gly Single submitter ⚠
p.Asp734Gly Single submitter ⚠
p.Gln1036His Single submitter ⚠
p.Gln1159Glu Single submitter ⚠
p.Gln1246Lys Single submitter ⚠
p.Gln419Glu Single submitter ⚠
p.Gln430Glu Single submitter ⚠
p.Gln843Lys Single submitter ⚠
p.Gln864Arg Single submitter ⚠
p.Gln871Ter Single submitter
p.Glu1120Gly Single submitter ⚠
p.Glu1182Gly Single submitter ⚠
p.Glu1207Gly Single submitter ⚠
p.Glu1245Ala Single submitter ⚠
p.Glu1252Ala Single submitter ⚠
p.Glu1272Val Single submitter ⚠
p.Glu1292Lys Single submitter ⚠
p.Glu1317Asp Single submitter ⚠
p.Glu1371Gly Single submitter ⚠
p.Glu1376Gly Single submitter ⚠
p.Glu471Gln Single submitter ⚠
p.Glu485Gly Single submitter ⚠
p.Glu635Lys Single submitter ⚠
p.Glu654Asp Single submitter ⚠
p.Glu831Lys Single submitter ⚠
p.Glu854Lys Single submitter ⚠
p.Glu877Val Single submitter ⚠
p.Glu960Lys Single submitter ⚠
p.Glu961Gly Single submitter ⚠
p.Glu974Gly Single submitter ⚠
p.Gly103Ser Single submitter
p.Gly103Val Single submitter ⚠
p.Gly1084Glu Single submitter ⚠
p.Gly157Val Single submitter ⚠
p.Gly199Ser Single submitter ⚠
p.Gly4Asp Single submitter ⚠
p.His1067Tyr Single submitter ⚠
p.His474Gln Single submitter ⚠
p.His507Tyr Single submitter
p.His652Arg Single submitter ⚠
p.His752Arg Single submitter ⚠
p.Ile1005Thr Single submitter ⚠
p.Ile1212Val Single submitter ⚠
p.Ile1225Asn Single submitter ⚠
p.Ile693Val Single submitter ⚠
p.Ile715Thr Single submitter ⚠
p.Ile878Met Single submitter ⚠
p.Leu1128Pro Single submitter ⚠
p.Leu1155Phe Single submitter ⚠
p.Leu1176Pro Single submitter ⚠
p.Leu1343Phe Single submitter ⚠
p.Leu323Phe Single submitter ⚠
p.Leu380Phe Single submitter ⚠
p.Leu54Pro Single submitter ⚠
p.Leu779Phe Single submitter ⚠
p.Leu782Phe Single submitter ⚠
p.Leu807Phe Single submitter ⚠
p.Lys1170Glu Single submitter ⚠
p.Lys1214Glu Single submitter ⚠
p.Lys1305Glu Single submitter ⚠
p.Lys1361Met Single submitter ⚠
p.Lys1381Thr Single submitter ⚠
p.Lys1383Asn Single submitter ⚠
p.Lys158Thr Single submitter
p.Lys475Arg Single submitter ⚠
p.Lys889Glu Single submitter ⚠
p.Met1074Ile Single submitter ⚠
p.Met119Val Single submitter ⚠
p.Met229Val Single submitter ⚠
p.Met988Val Single submitter ⚠
p.Met98Val Single submitter ⚠
p.Phe404Leu Single submitter ⚠
p.Pro36Thr Single submitter ⚠
p.Ser1088Tyr Single submitter ⚠
p.Ser1134Pro Single submitter ⚠
p.Ser1208Arg Single submitter ⚠
p.Ser21Arg Single submitter ⚠
p.Ser552Pro Single submitter braddock-carey syndrome 2 ⚠
p.Ser622Phe Single submitter ⚠
p.Ser777Pro Single submitter ⚠
p.Ser815Ala Single submitter ⚠
p.Thr1002Ile Single submitter ⚠
p.Thr1094Ile Single submitter ⚠
p.Thr1288Ile Single submitter ⚠
p.Thr353Ile Single submitter ⚠
p.Thr543Ser Single submitter ⚠
p.Thr57Met Single submitter ⚠
p.Thr637Ala Single submitter ⚠
p.Thr637del Single submitter
p.Thr655Ile Single submitter ⚠
p.Thr663Ser Single submitter ⚠
p.Thr769Ala Single submitter ⚠
p.Thr826Met Single submitter ⚠
p.Tyr821His Single submitter ⚠
p.Val1131Leu Single submitter ⚠
p.Val12Met Single submitter ⚠
p.Val1356Ile Single submitter ⚠
p.Val340Ile Single submitter ⚠
p.Val368Ile Single submitter ⚠
p.Val460Leu Single submitter ⚠
p.Val53Ala Single submitter ⚠
p.Val75Ile Single submitter ⚠
p.Val984Ile Single submitter ⚠