KIF18A — 114 ClinVar variants

All ClinVar germline KIF18A variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 102 flagged for review →

1 Conflicting · 1 Benign/Likely benign · 6 Likely benign · 106 Uncertain significance

Full KIF18A gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions

⚑ Evidence disagreements 102

Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.

Predictors agree, ClinVar conflicts 1

ClinVar submitters conflict, but the independent predictors unanimously agree — a QC review flag, not a reclassification.

KIF18A p.Pro882Leu Conflicting Single submitter

Predictors lean, ClinVar uncertain 92

ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.

Predictors split 9

The independent predictors disagree with each other — read with care.

All KIF18A variants

Conflicting classifications of pathogenicity 1

p.Pro882Leu Single submitter ⚠

Benign/Likely benign 1

p.Asp845= Multiple submitters

Likely benign 6

p.Gly269Ser Single submitter
p.Leu629Pro Single submitter
p.Ser883Asn Single submitter
p.Val51Ile Single submitter
p.Val846Ile Single submitter
p.Val854Ile Single submitter

Uncertain significance 106

p.Ala27Glu Single submitter ⚠
p.Ala27Val Single submitter ⚠
p.Ala296Thr Single submitter ⚠
p.Ala596Pro Single submitter ⚠
p.Arg168His Single submitter ⚠
p.Arg19Cys Single submitter ⚠
p.Arg250Cys Single submitter ⚠
p.Arg250His Single submitter ⚠
p.Arg264Gln Single submitter ⚠
p.Arg274Gln Single submitter ⚠
p.Arg300Gly Single submitter ⚠
p.Arg314His Single submitter ⚠
p.Arg490His Single submitter ⚠
p.Arg491Cys Single submitter ⚠
p.Arg668Gln Single submitter ⚠
p.Arg669Lys Single submitter ⚠
p.Arg886Gly Single submitter ⚠
p.Arg99His Single submitter ⚠
p.Asn173Ser Single submitter ⚠
p.Asn402Ser Single submitter ⚠
p.Asn594His Single submitter ⚠
p.Asn61His Single submitter ⚠
p.Asn738Ile Single submitter ⚠
p.Asn793Lys Single submitter ⚠
p.Asn847His Single submitter ⚠
p.Asp145Glu Single submitter ⚠
p.Asp354Tyr Single submitter ⚠
p.Asp481Glu Single submitter ⚠
p.Asp557Tyr Single submitter ⚠
p.Asp709Gly Single submitter ⚠
p.Asp81Ala Single submitter ⚠
p.Asp857Val Single submitter ⚠
p.Gln568Glu Single submitter ⚠
p.Gln645His Single submitter ⚠
p.Gln691Leu Single submitter ⚠
p.Gln701Arg Single submitter ⚠
p.Gln701His Single submitter ⚠
p.Gln786Leu Single submitter ⚠
p.Glu50Asp Single submitter ⚠
p.Glu531Asp Single submitter ⚠
p.Glu760Lys Single submitter ⚠
p.Glu764Lys Single submitter ⚠
p.Gly526Ser Single submitter ⚠
p.Gly591Ser Single submitter ⚠
p.Gly654Asp Single submitter ⚠
p.His11Arg Single submitter ⚠
p.His195Arg Single submitter ⚠
p.His217Tyr Single submitter ⚠
p.His229Leu Single submitter ⚠
p.His482Gln Single submitter ⚠
p.His527Arg Single submitter ⚠
p.His539Arg Single submitter ⚠
p.His55Leu Single submitter ⚠
p.His680Arg Single submitter ⚠
p.Ile152Met Single submitter ⚠
p.Ile327Thr Single submitter ⚠
p.Ile370Val Single submitter ⚠
p.Ile376Phe Single submitter
p.Ile552Val Single submitter ⚠
p.Ile65Lys Single submitter ⚠
p.Ile703Thr Single submitter ⚠
p.Ile735Asn Single submitter ⚠
p.Ile739Met Single submitter ⚠
p.Ile772Met Single submitter ⚠
p.Ile97Val Single submitter ⚠
p.Leu543Phe Single submitter ⚠
p.Leu587Val Single submitter ⚠
p.Leu72Phe Single submitter ⚠
p.Lys241Thr Single submitter
p.Lys347Asn Single submitter ⚠
p.Lys390Arg Single submitter ⚠
p.Lys453Arg Single submitter ⚠
p.Lys475Thr Single submitter ⚠
p.Lys496Arg Single submitter ⚠
p.Lys533Arg Single submitter ⚠
p.Lys602Ile Single submitter ⚠
p.Lys66Asn Single submitter
p.Lys828Arg Single submitter ⚠
p.Met466Ile Single submitter ⚠
p.Met556Ile Single submitter ⚠
p.Met672Ile Single submitter ⚠
p.Met723Thr Single submitter ⚠
p.Phe597Leu Single submitter ⚠
p.Pro648Arg Single submitter ⚠
p.Pro702Ser Single submitter ⚠
p.Pro707Ala Single submitter ⚠
p.Pro717Leu Single submitter ⚠
p.Pro869Arg Single submitter ⚠
p.Ser100Asn Single submitter ⚠
p.Ser268Cys Single submitter ⚠
p.Ser2Thr Single submitter ⚠
p.Ser361Asn Single submitter ⚠
p.Ser599Thr Single submitter ⚠
p.Ser840Cys Single submitter ⚠
p.Thr136Ala Single submitter ⚠
p.Thr155Ala Single submitter ⚠
p.Thr4Pro Single submitter ⚠
p.Thr706Ile Single submitter
p.Trp511Cys Single submitter
p.Tyr584Cys Single submitter ⚠
p.Val337Ala Single submitter ⚠
p.Val363Ile Single submitter ⚠
p.Val366Ile Single submitter ⚠
p.Val644Ile Single submitter ⚠
p.Val659Ala Single submitter ⚠
p.Val817Met Single submitter ⚠