Sugi Variant

Sugi Variant/KIF1C

KIF1C — 775 ClinVar variants

All ClinVar germline KIF1C variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 320 flagged for review →

15 Pathogenic · 3 Pathogenic/Likely pathogenic · 22 Likely pathogenic · 39 Conflicting · 53 Benign · 24 Benign/Likely benign · 279 Likely benign · 340 Uncertain significance

Full KIF1C gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions

⚑ Evidence disagreements 320

Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.

Predictors agree, ClinVar conflicts 18

ClinVar submitters conflict, but the independent predictors unanimously agree — a QC review flag, not a reclassification.

Predictors lean, ClinVar uncertain 225

ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification. · showing the 150 best-reviewed of 225

Predictors split 77

The independent predictors disagree with each other — read with care.

All KIF1C variants

Pathogenic 15

Pathogenic/Likely pathogenic 3

Likely pathogenic 22

Conflicting classifications of pathogenicity 39

Benign 53

Benign/Likely benign 24

Likely benign 279

Uncertain significance 340

Showing the top 300 by review status; the full set is in the sitemap.