Sugi Variant

Sugi Variant/KIF20A

KIF20A — 556 ClinVar variants

All ClinVar germline KIF20A variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 272 flagged for review →

1 Pathogenic · 1 Likely pathogenic · 2 Conflicting · 16 Benign · 1 Benign/Likely benign · 188 Likely benign · 347 Uncertain significance

Full KIF20A gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions

⚑ Evidence disagreements 272

Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.

Predictors agree, ClinVar conflicts 2

ClinVar submitters conflict, but the independent predictors unanimously agree — a QC review flag, not a reclassification.

Predictors lean, ClinVar uncertain 236

ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification. · showing the 150 best-reviewed of 236

Predictors split 34

The independent predictors disagree with each other — read with care.

All KIF20A variants

Pathogenic 1

  • p.Tyr637fs No assertion criteria cardiomyopathy, familial restrictive, 6

Likely pathogenic 1

  • p.Arg475Ter Single submitter cardiomyopathy, familial restrictive, 6

Conflicting classifications of pathogenicity 2

Benign 16

Benign/Likely benign 1

Likely benign 188

Uncertain significance 347

Showing the top 300 by review status; the full set is in the sitemap.