KIF20B — 285 ClinVar variants

All ClinVar germline KIF20B variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 246 flagged for review →

5 Benign · 26 Likely benign · 254 Uncertain significance

Full KIF20B gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions

⚑ Evidence disagreements 246

Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.

Predictors lean, ClinVar uncertain 217

ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification. · showing the 150 best-reviewed of 217

Predictors split 29

The independent predictors disagree with each other — read with care.

All KIF20B variants

Benign 5

p.Arg1362= Multiple submitters
p.Asn870Ser Multiple submitters
p.Leu1264= Multiple submitters
p.Ser377Thr Multiple submitters
p.Lys1103_Glu1104insValLys Single submitter

Likely benign 26

p.Ala889Thr Single submitter
p.Arg1270Cys Single submitter
p.Arg1571His Single submitter
p.Arg637Cys Single submitter
p.Asn1003Asp Single submitter
p.Asn1328= Single submitter
p.Asn1349Ser Single submitter
p.Asn771Asp Single submitter
p.Asn966His Single submitter
p.Asp1186Glu Single submitter
p.Glu1483= Single submitter
p.Glu676= Single submitter
p.Glu782Lys Single submitter
p.His39Arg Single submitter
p.Ile1139Val Single submitter
p.Ile1193Val Single submitter
p.Ile1700Thr Single submitter
p.Ile253Met Single submitter
p.Pro482= Single submitter
p.Ser1180Leu Single submitter
p.Ser1586Leu Single submitter
p.Thr893Ile Single submitter
p.Tyr282Cys Single submitter
p.Val1212Ile Single submitter
p.Val1541Ile Single submitter
p.Val90Leu Single submitter

Uncertain significance 254

c.4504-4T>C Single submitter
p.Ala1148Thr Single submitter ⚠
p.Ala1181Val Single submitter ⚠
p.Ala122Val Single submitter ⚠
p.Ala1266Val Single submitter ⚠
p.Ala1269Val Single submitter ⚠
p.Ala1473Val Single submitter ⚠
p.Ala1765Gly Single submitter ⚠
p.Ala19Asp Single submitter ⚠
p.Ala474Thr Single submitter ⚠
p.Ala542Asp Single submitter ⚠
p.Ala618Thr Single submitter ⚠
p.Ala656Val Single submitter ⚠
p.Arg1049Gly Single submitter ⚠
p.Arg1270His Single submitter ⚠
p.Arg1280Ser Single submitter
p.Arg1310Cys Single submitter ⚠
p.Arg1339Gln Single submitter ⚠
p.Arg1378Gln Single submitter ⚠
p.Arg146Cys Single submitter ⚠
p.Arg1493His Single submitter ⚠
p.Arg1617Gln Single submitter ⚠
p.Arg1654Trp Single submitter ⚠
p.Arg1677Gly Single submitter ⚠
p.Arg1677Thr Single submitter ⚠
p.Arg1711Trp Single submitter ⚠
p.Arg174Gln Single submitter ⚠
p.Arg1812Gln Single submitter ⚠
p.Arg328Gly Single submitter ⚠
p.Arg369Cys Single submitter ⚠
p.Arg432Trp Single submitter ⚠
p.Arg638Cys Single submitter ⚠
p.Arg765Ile Single submitter ⚠
p.Arg831Thr Single submitter ⚠
p.Asn1031Ser Single submitter ⚠
p.Asn1253Ser Single submitter ⚠
p.Asn1417Ser Single submitter ⚠
p.Asn1424Tyr Single submitter ⚠
p.Asn1478His Single submitter ⚠
p.Asn1481Tyr Single submitter ⚠
p.Asn1659Lys Single submitter ⚠
p.Asn1769His Single submitter ⚠
p.Asn265Ser Single submitter ⚠
p.Asn280Ser Single submitter ⚠
p.Asn509Lys Single submitter ⚠
p.Asn634Thr Single submitter ⚠
p.Asn792Ile Single submitter ⚠
p.Asn808Lys Single submitter ⚠
p.Asn966Asp Single submitter ⚠
p.Asp1005Ala Single submitter ⚠
p.Asp1136Asn Single submitter ⚠
p.Asp1238Asn Single submitter ⚠
p.Asp1287Gly Single submitter ⚠
p.Asp1335Tyr Single submitter ⚠
p.Asp1458Gly Single submitter ⚠
p.Asp1576Asn Single submitter ⚠
p.Asp1604Val Single submitter ⚠
p.Asp1664Glu Single submitter ⚠
p.Asp1687Gly Single submitter ⚠
p.Asp181Gly Single submitter ⚠
p.Asp528Asn Single submitter ⚠
p.Asp556Ala Single submitter ⚠
p.Asp558Val Single submitter ⚠
p.Asp644Glu Single submitter ⚠
p.Asp644His Single submitter ⚠
p.Asp990Gly Single submitter ⚠
p.Cys649Arg Single submitter ⚠
p.Cys796Phe Single submitter ⚠
p.Gln1173Arg Single submitter ⚠
p.Gln1185Glu Single submitter ⚠
p.Gln1244Arg Single submitter ⚠
p.Gln125Arg Single submitter ⚠
p.Gln1303Pro Single submitter ⚠
p.Gln1359His Single submitter ⚠
p.Gln1388Arg Single submitter ⚠
p.Gln1449Glu Single submitter ⚠
p.Gln1472Glu Single submitter ⚠
p.Gln1472His Single submitter ⚠
p.Gln1614Arg Single submitter ⚠
p.Gln1772Leu Single submitter ⚠
p.Gln500Glu Single submitter ⚠
p.Gln60His Single submitter ⚠
p.Gln60Pro Single submitter ⚠
p.Gln70Pro Single submitter ⚠
p.Gln719His Single submitter ⚠
p.Glu1063Lys Single submitter ⚠
p.Glu1066Asp Single submitter ⚠
p.Glu1116Gly Single submitter ⚠
p.Glu1176Lys Single submitter ⚠
p.Glu1198Gly Single submitter ⚠
p.Glu1203Lys Single submitter ⚠
p.Glu1227Val Single submitter ⚠
p.Glu1354Lys Single submitter ⚠
p.Glu1414Lys Single submitter ⚠
p.Glu1465Gly Single submitter ⚠
p.Glu1492Gln Single submitter ⚠
p.Glu1520Gln Single submitter ⚠
p.Glu185Asp Single submitter ⚠
p.Glu27Asp Single submitter ⚠
p.Glu385Lys Single submitter ⚠
p.Glu421Gly Single submitter ⚠
p.Glu490Lys Single submitter ⚠
p.Glu590Gly Single submitter ⚠
p.Glu629Lys Single submitter ⚠
p.Glu654Ala Single submitter ⚠
p.Glu665Gly Single submitter ⚠
p.Glu72Gly Single submitter ⚠
p.Glu830Ala Single submitter ⚠
p.Glu882Asp Single submitter ⚠
p.Glu897Gly Single submitter ⚠
p.Glu904Lys Single submitter ⚠
p.Glu991Asp Single submitter ⚠
p.Gly152Arg Single submitter ⚠
p.Gly308Ser Single submitter ⚠
p.Gly32Asp Single submitter ⚠
p.Gly729Ala Single submitter ⚠
p.His1179Gln Single submitter ⚠
p.His1431Pro Single submitter ⚠
p.His82Arg Single submitter ⚠
p.His948Pro Single submitter ⚠
p.His948Tyr Single submitter ⚠
p.Ile1078Asn Single submitter ⚠
p.Ile1121Arg Single submitter ⚠
p.Ile1121Thr Single submitter ⚠
p.Ile1187Thr Single submitter ⚠
p.Ile1193Met Single submitter ⚠
p.Ile1229Leu Single submitter ⚠
p.Ile1320Thr Single submitter ⚠
p.Ile133Val Single submitter ⚠
p.Ile1479Thr Single submitter ⚠
p.Ile1537Leu Single submitter ⚠
p.Ile1560Val Single submitter ⚠
p.Ile1564Val Single submitter ⚠
p.Ile1650Asn Single submitter ⚠
p.Ile1751Met Single submitter ⚠
p.Ile1791Thr Single submitter ⚠
p.Ile253Val Single submitter ⚠
p.Ile641Val Single submitter ⚠
p.Ile65Val Single submitter ⚠
p.Ile770Leu Single submitter ⚠
p.Ile780Thr Single submitter ⚠
p.Ile780Val Single submitter ⚠
p.Ile851Thr Single submitter ⚠
p.Ile871Thr Single submitter ⚠
p.Ile871Val Single submitter ⚠
p.Ile877Leu Single submitter ⚠
p.Ile942Thr Single submitter ⚠
p.Ile961Val Single submitter ⚠
p.Ile97Val Single submitter ⚠
p.Ile989Val Single submitter ⚠
p.Leu1120Pro Single submitter ⚠
p.Leu1128Trp Single submitter ⚠
p.Leu1197Pro Single submitter ⚠
p.Leu1201Trp Single submitter ⚠
p.Leu1316Pro Single submitter ⚠
p.Leu1515Val Single submitter ⚠
p.Leu1536Pro Single submitter ⚠
p.Leu1580Phe Single submitter ⚠
p.Leu1744Pro Single submitter ⚠
p.Leu187Pro Single submitter
p.Leu553Arg Single submitter ⚠
p.Leu587fs Single submitter
p.Leu786Val Single submitter ⚠
p.Leu892Val Single submitter ⚠
p.Lys1190Thr Single submitter
p.Lys1216Arg Single submitter ⚠
p.Lys1216Glu Single submitter ⚠
p.Lys1261Arg Single submitter ⚠
p.Lys1296Arg Single submitter ⚠
p.Lys1365Arg Single submitter ⚠
p.Lys1372Glu Single submitter ⚠
p.Lys138Arg Single submitter ⚠
p.Lys1398Gln Single submitter ⚠
p.Lys1466Glu Single submitter ⚠
p.Lys1652Arg Single submitter ⚠
p.Lys1657Arg Single submitter ⚠
p.Lys1681Arg Single submitter ⚠
p.Lys1747Glu Single submitter ⚠
p.Lys1820Glu Single submitter ⚠
p.Lys324Arg Single submitter ⚠
p.Lys497Thr Single submitter ⚠
p.Lys511Glu Single submitter ⚠
p.Lys516Arg Single submitter ⚠
p.Lys586Asn Single submitter ⚠
p.Lys663Glu Single submitter ⚠
p.Lys735Asn Single submitter ⚠
p.Lys810Glu Single submitter ⚠
p.Lys832Glu Single submitter ⚠
p.Lys847Glu Single submitter
p.Lys925Arg Single submitter ⚠
p.Lys931Arg Single submitter ⚠
p.Lys960Arg Single submitter ⚠
p.Lys988Asn Single submitter ⚠
p.Met1239Ile Single submitter ⚠
p.Met134Val Single submitter ⚠
p.Met388Val Single submitter ⚠
p.Met452Val Single submitter ⚠
p.Met530Ile Single submitter ⚠
p.Phe113Ile Single submitter ⚠
p.Phe276Val Single submitter ⚠
p.Phe493Ser Single submitter ⚠
p.Pro121Ser Single submitter
p.Pro1619Arg Single submitter ⚠
p.Pro1632Ala Single submitter
p.Pro482Gln Single submitter ⚠
p.Pro820Leu Single submitter ⚠
p.Pro845Leu Single submitter ⚠
p.Pro869Arg Single submitter ⚠
p.Pro869Leu Single submitter ⚠
p.Ser1211Pro Single submitter ⚠
p.Ser1586Pro Single submitter ⚠
p.Ser1746Leu Single submitter ⚠
p.Ser1766Gly Single submitter ⚠
p.Ser239Ile Single submitter ⚠
p.Ser292Cys Single submitter ⚠
p.Ser338Arg Single submitter ⚠
p.Ser338Asn Single submitter ⚠
p.Ser348Cys Single submitter ⚠
p.Ser420Asn Single submitter ⚠
p.Ser420Gly Single submitter ⚠
p.Ser498Pro Single submitter ⚠
p.Ser506Arg Single submitter ⚠
p.Ser864Cys Single submitter ⚠
p.Ser997Ala Single submitter ⚠
p.Thr1134Ile Single submitter ⚠
p.Thr1380Ile Single submitter ⚠
p.Thr1628Ile Single submitter ⚠
p.Thr1729Ala Single submitter ⚠
p.Thr189Ala Single submitter ⚠
p.Thr484Ser Single submitter ⚠
p.Thr596Asn Single submitter ⚠
p.Thr710Ala Single submitter ⚠
p.Thr893Ala Single submitter ⚠
p.Thr928Ala Single submitter ⚠
p.Trp1518Arg Single submitter ⚠
p.Tyr1159His Single submitter ⚠
p.Tyr1159Ser Single submitter ⚠
p.Tyr1285Asp Single submitter ⚠
p.Tyr1285His Single submitter ⚠
p.Tyr201His Single submitter ⚠
p.Tyr284Cys Single submitter ⚠
p.Tyr309Cys Single submitter ⚠
p.Tyr58His Single submitter ⚠
p.Val1212Phe Single submitter ⚠
p.Val1402Ile Single submitter ⚠
p.Val1437Leu Single submitter ⚠
p.Val1795Met Single submitter ⚠
p.Val339Ile Single submitter ⚠
p.Val416Ile Single submitter ⚠
p.Val548Glu Single submitter ⚠
p.Val646Ile Single submitter ⚠
p.Val853Phe Single submitter ⚠
p.Val90Gly Single submitter ⚠
p.Val949Met Single submitter ⚠