KIF2C — 86 ClinVar variants
All ClinVar germline KIF2C variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 78 flagged for review →
2 Likely benign · 84 Uncertain significance
Full KIF2C gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 78
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 65
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- KIF2C p.Ala158Thr Uncertain significance Single submitter
- KIF2C p.Ala241Gly Uncertain significance Single submitter
- KIF2C p.Ala369Val Uncertain significance Single submitter
- KIF2C p.Ala494Ser Uncertain significance Single submitter
- KIF2C p.Ala609Val Uncertain significance Single submitter
- KIF2C p.Ala614Val Uncertain significance Single submitter
- KIF2C p.Ala63Thr Uncertain significance Single submitter
- KIF2C p.Arg140His Uncertain significance Single submitter
- KIF2C p.Arg234Gln Uncertain significance Single submitter
- KIF2C p.Arg240Gln Uncertain significance Single submitter
- KIF2C p.Arg420His Uncertain significance Single submitter
- KIF2C p.Arg469His Uncertain significance Single submitter
- KIF2C p.Arg507Gly Uncertain significance Single submitter
- KIF2C p.Arg510Pro Uncertain significance Single submitter
- KIF2C p.Arg723Gln Uncertain significance Single submitter
- KIF2C p.Arg723Trp Uncertain significance Single submitter
- KIF2C p.Arg93Gln Uncertain significance Single submitter
- KIF2C p.Asn406Ser Uncertain significance Single submitter
- KIF2C p.Asn556Ile Uncertain significance Single submitter
- KIF2C p.Asn85Tyr Uncertain significance Single submitter
- KIF2C p.Asn97Lys Uncertain significance Single submitter
- KIF2C p.Cys193Arg Uncertain significance Single submitter
- KIF2C p.Cys245Gly Uncertain significance Single submitter
- KIF2C p.Cys287Tyr Uncertain significance Single submitter
- KIF2C p.Glu119Gln Uncertain significance Single submitter
- KIF2C p.Glu130Asp Uncertain significance Single submitter
- KIF2C p.Glu436Ala Uncertain significance Single submitter
- KIF2C p.Glu603Ala Uncertain significance Single submitter
- KIF2C p.Gly14Ser Uncertain significance Single submitter
- KIF2C p.Gly407Arg Uncertain significance Single submitter
- KIF2C p.His174Arg Uncertain significance Single submitter
- KIF2C p.His292Arg Uncertain significance Single submitter
- KIF2C p.Ile17Thr Uncertain significance Single submitter
- KIF2C p.Ile26Thr Uncertain significance Single submitter
- KIF2C p.Leu133Gln Uncertain significance Single submitter
- KIF2C p.Leu576Phe Uncertain significance Single submitter
- KIF2C p.Leu620Ile Uncertain significance Single submitter
- KIF2C p.Lys208Gln Uncertain significance Single submitter
- KIF2C p.Lys365Arg Uncertain significance Single submitter
- KIF2C p.Lys385Asn Uncertain significance Single submitter
- KIF2C p.Met114Thr Uncertain significance Single submitter
- KIF2C p.Met114Val Uncertain significance Single submitter
- KIF2C p.Met129Ile Uncertain significance Single submitter
- KIF2C p.Met129Val Uncertain significance Single submitter
- KIF2C p.Met164Val Uncertain significance Single submitter
- KIF2C p.Met3Val Uncertain significance Single submitter
- KIF2C p.Pro103Ser Uncertain significance Single submitter
- KIF2C p.Pro388Ala Uncertain significance Single submitter
- KIF2C p.Pro590Leu Uncertain significance Single submitter
- KIF2C p.Pro617Leu Uncertain significance Single submitter
- KIF2C p.Pro617Ser Uncertain significance Single submitter
- KIF2C p.Pro76Leu Uncertain significance Single submitter
- KIF2C p.Ser153Cys Uncertain significance Single submitter
- KIF2C p.Ser181Phe Uncertain significance Single submitter
- KIF2C p.Ser187Leu Uncertain significance Single submitter
- KIF2C p.Ser225Gly Uncertain significance Single submitter
- KIF2C p.Ser519Thr Uncertain significance Single submitter
- KIF2C p.Ser611Cys Uncertain significance Single submitter
- KIF2C p.Thr357Ile Uncertain significance Single submitter
- KIF2C p.Thr559Ala Uncertain significance Single submitter
- KIF2C p.Tyr374Asn Uncertain significance Single submitter
- KIF2C p.Val131Ala Uncertain significance Single submitter
- KIF2C p.Val157Ala Uncertain significance Single submitter
- KIF2C p.Val280Met Uncertain significance Single submitter
- KIF2C p.Val96Ile Uncertain significance Single submitter
Predictors split 13
The independent predictors disagree with each other — read with care.
- KIF2C p.Ala514Thr Uncertain significance Single submitter
- KIF2C p.Arg113Cys Uncertain significance Single submitter
- KIF2C p.Arg113His Uncertain significance Single submitter
- KIF2C p.Arg391Trp Uncertain significance Single submitter
- KIF2C p.Arg507Trp Uncertain significance Single submitter
- KIF2C p.Gln20Pro Uncertain significance Single submitter
- KIF2C p.Glu255Lys Uncertain significance Single submitter
- KIF2C p.Gly425Ser Uncertain significance Single submitter
- KIF2C p.Ile553Thr Uncertain significance Single submitter
- KIF2C p.Lys200Glu Uncertain significance Single submitter
- KIF2C p.Tyr674Cys Uncertain significance Single submitter
- KIF2C p.Val31Leu Uncertain significance Single submitter
- KIF2C p.Val445Ile Uncertain significance Single submitter
All KIF2C variants
Likely benign 2
- p.Arg698Gln Single submitter
- p.Leu644= Single submitter
Uncertain significance 84
- p.Ala158Thr Single submitter ⚠
- p.Ala241Gly Single submitter ⚠
- p.Ala369Val Single submitter ⚠
- p.Ala494Ser Single submitter ⚠
- p.Ala514Thr Single submitter ⚠
- p.Ala609Val Single submitter ⚠
- p.Ala614Val Single submitter ⚠
- p.Ala63Thr Single submitter ⚠
- p.Arg113Cys Single submitter ⚠
- p.Arg113His Single submitter ⚠
- p.Arg140His Single submitter ⚠
- p.Arg234Gln Single submitter ⚠
- p.Arg240Gln Single submitter ⚠
- p.Arg240Trp Single submitter
- p.Arg391Trp Single submitter ⚠
- p.Arg420His Single submitter ⚠
- p.Arg469His Single submitter ⚠
- p.Arg507Gly Single submitter ⚠
- p.Arg507Trp Single submitter ⚠
- p.Arg510Pro Single submitter ⚠
- p.Arg723Gln Single submitter ⚠
- p.Arg723Trp Single submitter ⚠
- p.Arg93Gln Single submitter ⚠
- p.Asn406Ser Single submitter ⚠
- p.Asn556Ile Single submitter ⚠
- p.Asn85Tyr Single submitter ⚠
- p.Asn97Lys Single submitter ⚠
- p.Cys193Arg Single submitter ⚠
- p.Cys245Gly Single submitter ⚠
- p.Cys287Tyr Single submitter ⚠
- p.Gln20Pro Single submitter ⚠
- p.Glu119Gln Single submitter ⚠
- p.Glu130Asp Single submitter ⚠
- p.Glu255Lys Single submitter ⚠
- p.Glu436Ala Single submitter ⚠
- p.Glu603Ala Single submitter ⚠
- p.Gly14Ser Single submitter ⚠
- p.Gly407Arg Single submitter ⚠
- p.Gly425Ser Single submitter ⚠
- p.His174Arg Single submitter ⚠
- p.His257Asp Single submitter
- p.His292Arg Single submitter ⚠
- p.Ile17Thr Single submitter ⚠
- p.Ile26Thr Single submitter ⚠
- p.Ile553Thr Single submitter ⚠
- p.Ile56Thr Single submitter
- p.Leu133Gln Single submitter ⚠
- p.Leu576Phe Single submitter ⚠
- p.Leu620Ile Single submitter ⚠
- p.Leu676Pro Single submitter
- p.Lys200Glu Single submitter ⚠
- p.Lys208Gln Single submitter ⚠
- p.Lys365Arg Single submitter ⚠
- p.Lys385Asn Single submitter ⚠
- p.Met114Thr Single submitter ⚠
- p.Met114Val Single submitter ⚠
- p.Met129Ile Single submitter ⚠
- p.Met129Val Single submitter ⚠
- p.Met164Val Single submitter ⚠
- p.Met3Val Single submitter ⚠
- p.Met708Thr Single submitter
- p.Pro103Ser Single submitter ⚠
- p.Pro388Ala Single submitter ⚠
- p.Pro590Leu Single submitter ⚠
- p.Pro617Leu Single submitter ⚠
- p.Pro617Ser Single submitter ⚠
- p.Pro76Leu Single submitter ⚠
- p.Ser153Cys Single submitter ⚠
- p.Ser181Phe Single submitter ⚠
- p.Ser187Leu Single submitter ⚠
- p.Ser225Gly Single submitter ⚠
- p.Ser458Thr Single submitter
- p.Ser519Thr Single submitter ⚠
- p.Ser611Cys Single submitter ⚠
- p.Thr357Ile Single submitter ⚠
- p.Thr559Ala Single submitter ⚠
- p.Tyr374Asn Single submitter ⚠
- p.Tyr674Cys Single submitter ⚠
- p.Val131Ala Single submitter ⚠
- p.Val157Ala Single submitter ⚠
- p.Val280Met Single submitter ⚠
- p.Val31Leu Single submitter ⚠
- p.Val445Ile Single submitter ⚠
- p.Val96Ile Single submitter ⚠