KIFC1 — 98 ClinVar variants

All ClinVar germline KIFC1 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 76 flagged for review →

1 Benign · 17 Likely benign · 80 Uncertain significance

Full KIFC1 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions

⚑ Evidence disagreements 76

Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.

Predictors lean, ClinVar uncertain 65

ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.

Predictors split 11

The independent predictors disagree with each other — read with care.

All KIFC1 variants

Benign 1

c.*15_*16dup Single submitter

Likely benign 17

p.Ala281Thr Single submitter
p.Ala515Thr Single submitter
p.Arg19Thr Single submitter
p.Arg253Gly Single submitter
p.Arg347His Single submitter
p.Arg489His Single submitter
p.Arg521His Single submitter
p.Gln204Arg Single submitter
p.Gly381Glu Single submitter
p.Gly450= Single submitter
p.Ile15Thr Single submitter
p.Ser264Gly Single submitter
p.Thr222Met Single submitter
p.Thr477Ala Single submitter
p.Thr498Ile Single submitter
p.Thr53Ile Single submitter
p.Thr74Ala Single submitter

Uncertain significance 80

p.Ala24Ser Single submitter ⚠
p.Ala260Val Single submitter ⚠
p.Arg134His Single submitter ⚠
p.Arg152Trp Single submitter ⚠
p.Arg154His Single submitter ⚠
p.Arg154Leu Single submitter ⚠
p.Arg185His Single submitter ⚠
p.Arg210Pro Single submitter ⚠
p.Arg241Gln Single submitter ⚠
p.Arg286Trp Single submitter ⚠
p.Arg289His Single submitter ⚠
p.Arg297His Single submitter ⚠
p.Arg299Gln Single submitter ⚠
p.Arg312Cys Single submitter ⚠
p.Arg356Trp Single submitter ⚠
p.Arg369Cys Single submitter ⚠
p.Arg38Ser Single submitter ⚠
p.Arg52Trp Single submitter ⚠
p.Arg534Gln Single submitter ⚠
p.Arg537Cys Single submitter ⚠
p.Arg537Leu Single submitter ⚠
p.Arg553Gln Single submitter ⚠
p.Arg583Gln Single submitter ⚠
p.Arg583Leu Single submitter ⚠
p.Arg616Trp Single submitter ⚠
p.Arg94Gln Single submitter ⚠
p.Asn501Ser Single submitter ⚠
p.Asn593Ile Single submitter ⚠
p.Asn671His Single submitter ⚠
p.Asn671Lys Single submitter
p.Asp173Val Single submitter ⚠
p.Asp514Gly Single submitter ⚠
p.Cys557Arg Single submitter
p.Cys557Gly Single submitter ⚠
p.Cys557Tyr Single submitter
p.Cys663Phe Single submitter ⚠
p.Gln106Arg Single submitter ⚠
p.Gln165Glu Single submitter ⚠
p.Glu189Asp Single submitter ⚠
p.Glu239Val Single submitter ⚠
p.Glu447Gly Single submitter ⚠
p.Glu644Ala Single submitter ⚠
p.Glu644Gly Single submitter ⚠
p.Gly13Trp Single submitter ⚠
p.Gly243Val Single submitter ⚠
p.Gly309Ser Single submitter ⚠
p.Gly323Ala Single submitter ⚠
p.Gly339Asp Single submitter ⚠
p.Gly480Arg Single submitter ⚠
p.Gly579Ser Single submitter ⚠
p.Gly581Arg Single submitter ⚠
p.Gly92Arg Single submitter ⚠
p.His550Arg Single submitter
p.Leu150Val Single submitter ⚠
p.Leu332Phe Single submitter ⚠
p.Leu56Pro Single submitter ⚠
p.Phe374Cys Single submitter ⚠
p.Phe378Leu Single submitter ⚠
p.Pro108Thr Single submitter ⚠
p.Pro322Leu Single submitter ⚠
p.Pro328Thr Single submitter ⚠
p.Pro335Leu Single submitter ⚠
p.Pro366Thr Single submitter ⚠
p.Pro380Ser Single submitter ⚠
p.Pro642Ser Single submitter ⚠
p.Pro7Ser Single submitter ⚠
p.Pro93Ala Single submitter ⚠
p.Ser26Thr Single submitter ⚠
p.Ser271Tyr Single submitter ⚠
p.Ser361Ile Single submitter ⚠
p.Ser443Cys Single submitter ⚠
p.Ser456Arg Single submitter ⚠
p.Thr368Ala Single submitter ⚠
p.Thr64Ile Single submitter ⚠
p.Trp137Gly Single submitter ⚠
p.Val458Ile Single submitter ⚠
p.Val462Ala Single submitter ⚠
p.Val462Ile Single submitter ⚠
p.Val638Leu Single submitter ⚠
p.Val87Phe Single submitter ⚠