KLF10 — 298 ClinVar variants
All ClinVar germline KLF10 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 158 flagged for review →
23 Benign · 101 Likely benign · 174 Uncertain significance
Full KLF10 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 158
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 131
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- KLF10 p.Ala111Val Uncertain significance Multiple submitters
- KLF10 p.Ala113Pro Uncertain significance Multiple submitters
- KLF10 p.Ala132Thr Uncertain significance Multiple submitters
- KLF10 p.Ala203Ser Uncertain significance Multiple submitters
- KLF10 p.Ala316Thr Uncertain significance Multiple submitters
- KLF10 p.Ala354Val Uncertain significance Multiple submitters
-
KLF10 p.Ala355Ser
Uncertain significance
Multiple submitters
KLF10-related hypertrophic cardiomyopathy
- KLF10 p.Ala430Thr Uncertain significance Multiple submitters
- KLF10 p.Ala471Val Uncertain significance Multiple submitters
- KLF10 p.Arg242Met Uncertain significance Multiple submitters
- KLF10 p.Arg449Gln Uncertain significance Multiple submitters
- KLF10 p.Asp219Glu Uncertain significance Multiple submitters
- KLF10 p.Asp219Val Uncertain significance Multiple submitters
- KLF10 p.Asp221Tyr Uncertain significance Multiple submitters
- KLF10 p.Leu122Val Uncertain significance Multiple submitters
- KLF10 p.Lys58Asn Uncertain significance Multiple submitters
- KLF10 p.Met18Ile Uncertain significance Multiple submitters
- KLF10 p.Met27Thr Uncertain significance Multiple submitters
- KLF10 p.Pro112Ser Uncertain significance Multiple submitters
- KLF10 p.Pro128Leu Uncertain significance Multiple submitters
- KLF10 p.Pro332Leu Uncertain significance Multiple submitters
-
KLF10 p.Pro336Leu
Uncertain significance
Multiple submitters
KLF10-related disorder
- KLF10 p.Pro348Leu Uncertain significance Multiple submitters
- KLF10 p.Pro79Leu Uncertain significance Multiple submitters
- KLF10 p.Ser140Arg Uncertain significance Multiple submitters
- KLF10 p.Thr125Ser Uncertain significance Multiple submitters
- KLF10 p.Val217Met Uncertain significance Multiple submitters
- KLF10 p.Val220Ala Uncertain significance Multiple submitters
- KLF10 p.Val285Ile Uncertain significance Multiple submitters
- KLF10 p.Val334Ala Uncertain significance Multiple submitters
- KLF10 p.Val60Phe Uncertain significance Multiple submitters
- KLF10 p.Ala113Val Uncertain significance Single submitter
- KLF10 p.Ala126Gly Uncertain significance Single submitter
- KLF10 p.Ala132Ser Uncertain significance Single submitter
- KLF10 p.Ala152Val Uncertain significance Single submitter
- KLF10 p.Ala204Thr Uncertain significance Single submitter
- KLF10 p.Ala264Thr Uncertain significance Single submitter
- KLF10 p.Ala264Val Uncertain significance Single submitter
- KLF10 p.Ala354Thr Uncertain significance Single submitter
- KLF10 p.Ala448Gly Uncertain significance Single submitter
- KLF10 p.Ala471Gly Uncertain significance Single submitter
- KLF10 p.Ala477Thr Uncertain significance Single submitter
- KLF10 p.Arg186Lys Uncertain significance Single submitter
- KLF10 p.Arg188Thr Uncertain significance Single submitter
- KLF10 p.Arg412His Uncertain significance Single submitter
- KLF10 p.Arg437Gln Uncertain significance Single submitter
- KLF10 p.Arg437Trp Uncertain significance Single submitter
- KLF10 p.Arg450Cys Uncertain significance Single submitter
- KLF10 p.Arg450His Uncertain significance Single submitter
- KLF10 p.Asn108His Uncertain significance Single submitter
- KLF10 p.Asn182Ser Uncertain significance Single submitter
- KLF10 p.Asn199Ser Uncertain significance Single submitter
- KLF10 p.Asn283His Uncertain significance Single submitter
- KLF10 p.Asn3Thr Uncertain significance Single submitter
- KLF10 p.Asp219Gly Uncertain significance Single submitter
- KLF10 p.Asp83Gly Uncertain significance Single submitter
- KLF10 p.Cys241Arg Uncertain significance Single submitter
- KLF10 p.Cys241Phe Uncertain significance Single submitter
- KLF10 p.Gln181Lys Uncertain significance Single submitter
- KLF10 p.Gln323Arg Uncertain significance Single submitter
- KLF10 p.Gln360Arg Uncertain significance Single submitter
- KLF10 p.Glu136Asp Uncertain significance Single submitter
- KLF10 p.Glu75Asp Uncertain significance Single submitter
- KLF10 p.Gly265Trp Uncertain significance Single submitter
- KLF10 p.Gly80Ala Uncertain significance Single submitter
- KLF10 p.His129Leu Uncertain significance Single submitter
- KLF10 p.His167Tyr Uncertain significance Single submitter
- KLF10 p.Ile130Val Uncertain significance Single submitter
- KLF10 p.Ile200Val Uncertain significance Single submitter
- KLF10 p.Ile240Phe Uncertain significance Single submitter
- KLF10 p.Ile361Asn Uncertain significance Single submitter
- KLF10 p.Ile470Met Uncertain significance Single submitter
- KLF10 p.Ile87Val Uncertain significance Single submitter
- KLF10 p.Leu256Val Uncertain significance Single submitter
- KLF10 p.Leu279Phe Uncertain significance Single submitter
- KLF10 p.Leu341Val Uncertain significance Single submitter
- KLF10 p.Lys135Arg Uncertain significance Single submitter
- KLF10 p.Lys139Asn Uncertain significance Single submitter
- KLF10 p.Lys146Arg Uncertain significance Single submitter
- KLF10 p.Lys198Arg Uncertain significance Single submitter
- KLF10 p.Lys253Gln Uncertain significance Single submitter
- KLF10 p.Lys314Arg Uncertain significance Single submitter
- KLF10 p.Lys330Glu Uncertain significance Single submitter
- KLF10 p.Met172Val Uncertain significance Single submitter
- KLF10 p.Met462Leu Uncertain significance Single submitter
- KLF10 p.Pro207Leu Uncertain significance Single submitter
- KLF10 p.Pro23Leu Uncertain significance Single submitter
- KLF10 p.Pro245Thr Uncertain significance Single submitter
- KLF10 p.Pro247Thr Uncertain significance Single submitter
- KLF10 p.Pro269Ser Uncertain significance Single submitter
- KLF10 p.Pro278Ser Uncertain significance Single submitter
- KLF10 p.Pro291Arg Uncertain significance Single submitter
- KLF10 p.Pro294Ser Uncertain significance Single submitter
- KLF10 p.Pro295His Uncertain significance Single submitter
- KLF10 p.Pro299Ser Uncertain significance Single submitter
- KLF10 p.Pro336Arg Uncertain significance Single submitter
- KLF10 p.Pro343Thr Uncertain significance Single submitter
- KLF10 p.Pro348Ala Uncertain significance Single submitter
- KLF10 p.Pro359His Uncertain significance Single submitter
- KLF10 p.Pro474Leu Uncertain significance Single submitter
- KLF10 p.Pro88Ala Uncertain significance Single submitter
- KLF10 p.Ser104Ala Uncertain significance Single submitter
- KLF10 p.Ser210Thr Uncertain significance Single submitter
- KLF10 p.Ser232Phe Uncertain significance Single submitter
- KLF10 p.Ser235Phe Uncertain significance Single submitter
- KLF10 p.Ser258Phe Uncertain significance Single submitter
- KLF10 p.Ser26Arg Uncertain significance Single submitter
- KLF10 p.Ser292Asn Uncertain significance Single submitter
- KLF10 p.Ser296Arg Uncertain significance Single submitter
- KLF10 p.Ser296Ile Uncertain significance Single submitter
- KLF10 p.Ser364Thr Uncertain significance Single submitter
- KLF10 p.Ser69Pro Uncertain significance Single submitter
- KLF10 p.Thr116Pro Uncertain significance Single submitter
- KLF10 p.Thr216Ala Uncertain significance Single submitter
- KLF10 p.Thr238Met Uncertain significance Single submitter
- KLF10 p.Thr287Arg Uncertain significance Single submitter
- KLF10 p.Thr390Met Uncertain significance Single submitter
- KLF10 p.Thr392Met Uncertain significance Single submitter
- KLF10 p.Thr475Ala Uncertain significance Single submitter
- KLF10 p.Thr86Pro Uncertain significance Single submitter
- KLF10 p.Tyr180Cys Uncertain significance Single submitter
- KLF10 p.Tyr229Asp Uncertain significance Single submitter
- KLF10 p.Tyr229His Uncertain significance Single submitter
- KLF10 p.Tyr229Phe Uncertain significance Single submitter
- KLF10 p.Val193Ile Uncertain significance Single submitter
- KLF10 p.Val257Ile Uncertain significance Single submitter
- KLF10 p.Val262Leu Uncertain significance Single submitter
- KLF10 p.Val290Ile Uncertain significance Single submitter
- KLF10 p.Val301Ile Uncertain significance Single submitter
- KLF10 p.Val325Ile Uncertain significance Single submitter
- KLF10 p.Val333Met Uncertain significance Single submitter
Predictors split 27
The independent predictors disagree with each other — read with care.
- KLF10 p.Arg187Ser Uncertain significance Multiple submitters
- KLF10 p.Pro304His Uncertain significance Multiple submitters
- KLF10 p.Trp30Arg Uncertain significance Multiple submitters
- KLF10 p.Trp52Cys Uncertain significance Multiple submitters
- KLF10 p.Tyr59Cys Uncertain significance Multiple submitters
- KLF10 p.Arg186Ile Benign Single submitter
- KLF10 p.Arg421Gln Uncertain significance Single submitter
- KLF10 p.Asp161Asn Uncertain significance Single submitter
- KLF10 p.Cys202Tyr Uncertain significance Single submitter
- KLF10 p.Cys212Trp Uncertain significance Single submitter
- KLF10 p.Glu40Gly Uncertain significance Single submitter
- KLF10 p.Gly377Ser Uncertain significance Single submitter
- KLF10 p.Lys36Asn Uncertain significance Single submitter
- KLF10 p.Lys456Asn Uncertain significance Single submitter
- KLF10 p.Met433Thr Uncertain significance Single submitter
- KLF10 p.Met46Thr Uncertain significance Single submitter
- KLF10 p.Phe101Leu Uncertain significance Single submitter
- KLF10 p.Phe185Ser Uncertain significance Single submitter
- KLF10 p.Phe319Leu Uncertain significance Single submitter
- KLF10 p.Phe350Leu Uncertain significance Single submitter
- KLF10 p.Pro271Arg Uncertain significance Single submitter
- KLF10 p.Pro374Ser Uncertain significance Single submitter
- KLF10 p.Pro82Ala Uncertain significance Single submitter
- KLF10 p.Pro88Ser Uncertain significance Single submitter
- KLF10 p.Ser176Arg Uncertain significance Single submitter
- KLF10 p.Ser400Asn Uncertain significance Single submitter
- KLF10 p.Ser69Cys Uncertain significance Single submitter
All KLF10 variants
Benign 23
- c.1184-17G>T Multiple submitters
- c.37-1346C>T Multiple submitters
- c.37-888G>A Multiple submitters
- c.*141C>T Multiple submitters
- c.*167C>T Multiple submitters
- p.Ser249Phe Multiple submitters
- p.Thr216= Multiple submitters
- p.Thr390= Multiple submitters
- c.1184-233A>G Single submitter
- c.271-22dup Single submitter
- c.36+13G>A Single submitter
- c.36+1455C>G Single submitter
- c.36+1576T>A Single submitter
- c.36+182C>G Single submitter
- c.37-74del Single submitter
- c.37-93_37-92dup Single submitter
- c.37-93dup Single submitter
- p.Arg186Ile Single submitter ⚠
- p.Ile273= Single submitter
- p.Pro336= Single submitter
- p.Ser225Asn Single submitter
- p.Thr189Ser Single submitter
- p.Thr392= Single submitter
Likely benign 101
- c.36+53G>T Multiple submitters
- p.Gln10His Multiple submitters
- p.Pro201= Multiple submitters
- p.Val42= Multiple submitters
- c.1183+14_1183+16del Single submitter
- c.1183+14C>G Single submitter
- c.1183+17A>C Single submitter
- c.1183+17A>T Single submitter
- c.1183+19A>C Single submitter
- c.1183+20T>G Single submitter
- c.1184-11C>T Single submitter
- c.1184-15A>G Single submitter
- c.1184-16T>G Single submitter
- c.1184-17G>C Single submitter
- c.1184-8del Single submitter
- c.270+15T>C Single submitter
- c.270+8T>G Single submitter
- c.271-11del Single submitter
- c.271-12C>T Single submitter
- c.271-14T>C Single submitter
- c.271-20T>C Single submitter
- c.36+13G>C Single submitter
- c.36+7C>A Single submitter
- c.36+8A>C Single submitter
- c.37-15C>G Single submitter
- c.37-76_37-74dup Single submitter
- c.*7G>A Single submitter
- p.Ala131= Single submitter
- p.Ala203= Single submitter
- p.Ala204= Single submitter
- p.Ala300= Single submitter
- p.Ala345= Single submitter
- p.Ala388= Single submitter
- p.Ala430= Single submitter
- p.Ala44= Single submitter
- p.Arg187= Single submitter
- p.Arg197= Single submitter
- p.Arg365= Single submitter
- p.Arg450= Single submitter
- p.Asn166= Single submitter
- p.Asn179= Single submitter
- p.Asn192= Single submitter
- p.Asn337= Single submitter
- p.Asp435= Single submitter
- p.Cys302= Single submitter
- p.Gln181= Single submitter
- p.Gln252= Single submitter
- p.Glu136= Single submitter
- p.Glu407= Single submitter
- p.Gly315= Single submitter
- p.His118= Single submitter
- p.His190= Single submitter
- p.His369= Single submitter
- p.His419= Single submitter
- p.Ile130= Single submitter
- p.Ile240= Single submitter
- p.Leu178= Single submitter
- p.Leu228= Single submitter
- p.Leu341= Single submitter
- p.Leu452= Single submitter
- p.Leu467= Single submitter
- p.Lys24= Single submitter
- p.Lys253= Single submitter
- p.Lys53= Single submitter
- p.Phe307= Single submitter
- p.Pro141= Single submitter
- p.Pro23= Single submitter
- p.Pro271= Single submitter
- p.Pro284= Single submitter
- p.Pro291= Single submitter
- p.Pro303= Single submitter
- p.Pro332= Single submitter
- p.Pro346= Single submitter
- p.Pro432= Single submitter
- p.Pro476= Single submitter
- p.Pro79= Single submitter
- p.Ser140= Single submitter
- p.Ser184= Single submitter
- p.Ser232= Single submitter
- p.Ser258= Single submitter
- p.Ser363Ala Single submitter
- p.Ser453= Single submitter
- p.Ser51= Single submitter
- p.Thr159= Single submitter
- p.Thr238= Single submitter
- p.Thr287= Single submitter
- p.Thr288= Single submitter
- p.Thr424= Single submitter
- p.Thr475= Single submitter
- p.Tyr59= Single submitter
- p.Tyr96= Single submitter
- p.Val142= Single submitter
- p.Val217= Single submitter
- p.Val239= Single submitter
- p.Val257= Single submitter
- p.Val262= Single submitter
- p.Val289= Single submitter
- p.Val305= Single submitter
- p.Val320= Single submitter
- p.Val357= Single submitter
- p.Pro259= No assertion criteria KLF10-related disorder
Uncertain significance 174
- p.Ala111Val Multiple submitters ⚠
- p.Ala113Pro Multiple submitters ⚠
- p.Ala132Thr Multiple submitters ⚠
- p.Ala203Ser Multiple submitters ⚠
- p.Ala316Thr Multiple submitters ⚠
- p.Ala354Val Multiple submitters ⚠
- p.Ala355Ser Multiple submitters KLF10-related hypertrophic cardiomyopathy ⚠
- p.Ala430Thr Multiple submitters ⚠
- p.Ala471Val Multiple submitters ⚠
- p.Arg187Ser Multiple submitters ⚠
- p.Arg242Met Multiple submitters ⚠
- p.Arg449Gln Multiple submitters ⚠
- p.Asp219Glu Multiple submitters ⚠
- p.Asp219Val Multiple submitters ⚠
- p.Asp221Tyr Multiple submitters ⚠
- p.Leu122Val Multiple submitters ⚠
- p.Lys58Asn Multiple submitters ⚠
- p.Met18Ile Multiple submitters ⚠
- p.Met27Thr Multiple submitters ⚠
- p.Pro112Ser Multiple submitters ⚠
- p.Pro128Leu Multiple submitters ⚠
- p.Pro304His Multiple submitters ⚠
- p.Pro332Leu Multiple submitters ⚠
- p.Pro336Leu Multiple submitters KLF10-related disorder ⚠
- p.Pro348Leu Multiple submitters ⚠
- p.Pro79Leu Multiple submitters ⚠
- p.Ser140Arg Multiple submitters ⚠
- p.Thr125Ser Multiple submitters ⚠
- p.Trp30Arg Multiple submitters ⚠
- p.Trp52Cys Multiple submitters ⚠
- p.Tyr59Cys Multiple submitters ⚠
- p.Val217Met Multiple submitters ⚠
- p.Val220Ala Multiple submitters ⚠
- p.Val285Ile Multiple submitters ⚠
- p.Val334Ala Multiple submitters ⚠
- p.Val60Phe Multiple submitters ⚠
- c.1183+5C>G Single submitter
- c.36+2T>C Single submitter
- c.36+3_36+4del Single submitter
- p.Ala113Val Single submitter ⚠
- p.Ala12= Single submitter
- p.Ala126Gly Single submitter ⚠
- p.Ala132Ser Single submitter ⚠
- p.Ala152Val Single submitter ⚠
- p.Ala204Thr Single submitter ⚠
- p.Ala264Thr Single submitter ⚠
- p.Ala264Val Single submitter ⚠
- p.Ala354Thr Single submitter ⚠
- p.Ala448Gly Single submitter ⚠
- p.Ala471Gly Single submitter ⚠
- p.Ala477Thr Single submitter ⚠
- p.Arg186Lys Single submitter ⚠
- p.Arg188del Single submitter
- p.Arg188Thr Single submitter ⚠
- p.Arg412His Single submitter ⚠
- p.Arg421Gln Single submitter ⚠
- p.Arg437Gln Single submitter ⚠
- p.Arg437Trp Single submitter ⚠
- p.Arg450Cys Single submitter ⚠
- p.Arg450His Single submitter ⚠
- p.Asn108His Single submitter ⚠
- p.Asn182Ser Single submitter ⚠
- p.Asn199Ser Single submitter ⚠
- p.Asn283His Single submitter ⚠
- p.Asn3Thr Single submitter ⚠
- p.Asp161Asn Single submitter ⚠
- p.Asp219Gly Single submitter ⚠
- p.Asp83Gly Single submitter ⚠
- p.Cys202Tyr Single submitter ⚠
- p.Cys212Trp Single submitter ⚠
- p.Cys241Arg Single submitter ⚠
- p.Cys241Phe Single submitter ⚠
- p.Gln105= Single submitter
- p.Gln181Lys Single submitter ⚠
- p.Gln323Arg Single submitter ⚠
- p.Gln360_Ser364del Single submitter
- p.Gln360Arg Single submitter ⚠
- p.Glu136Asp Single submitter ⚠
- p.Glu136fs Single submitter
- p.Glu407Gly Single submitter
- p.Glu40Gly Single submitter ⚠
- p.Glu75Asp Single submitter ⚠
- p.Gly265Trp Single submitter ⚠
- p.Gly377Ser Single submitter ⚠
- p.Gly80Ala Single submitter ⚠
- p.His129Leu Single submitter ⚠
- p.His167Tyr Single submitter ⚠
- p.Ile130Val Single submitter ⚠
- p.Ile200Val Single submitter ⚠
- p.Ile240Phe Single submitter ⚠
- p.Ile361Asn Single submitter ⚠
- p.Ile470Met Single submitter ⚠
- p.Ile87Val Single submitter ⚠
- p.Leu256Val Single submitter ⚠
- p.Leu279Phe Single submitter ⚠
- p.Leu341Val Single submitter ⚠
- p.Lys135Arg Single submitter ⚠
- p.Lys139Asn Single submitter ⚠
- p.Lys146Arg Single submitter ⚠
- p.Lys146fs Single submitter
- p.Lys198Arg Single submitter ⚠
- p.Lys253Gln Single submitter ⚠
- p.Lys314Arg Single submitter ⚠
- p.Lys330Glu Single submitter ⚠
- p.Lys36Asn Single submitter ⚠
- p.Lys456Asn Single submitter ⚠
- p.Met172Val Single submitter ⚠
- p.Met433Thr Single submitter ⚠
- p.Met462Leu Single submitter ⚠
- p.Met46Thr Single submitter ⚠
- p.Phe101Leu Single submitter ⚠
- p.Phe185Ser Single submitter ⚠
- p.Phe319Leu Single submitter ⚠
- p.Phe350Leu Single submitter ⚠
- p.Pro207Leu Single submitter ⚠
- p.Pro23Leu Single submitter ⚠
- p.Pro245Thr Single submitter ⚠
- p.Pro247Thr Single submitter ⚠
- p.Pro269Ser Single submitter ⚠
- p.Pro271Arg Single submitter ⚠
- p.Pro278Ser Single submitter ⚠
- p.Pro291Arg Single submitter ⚠
- p.Pro294Ser Single submitter ⚠
- p.Pro295His Single submitter ⚠
- p.Pro299Ser Single submitter ⚠
- p.Pro304Arg Single submitter
- p.Pro336Arg Single submitter ⚠
- p.Pro343Thr Single submitter ⚠
- p.Pro348Ala Single submitter ⚠
- p.Pro359His Single submitter ⚠
- p.Pro374Ser Single submitter ⚠
- p.Pro474Leu Single submitter ⚠
- p.Pro82Ala Single submitter ⚠
- p.Pro88Ala Single submitter ⚠
- p.Pro88Ser Single submitter ⚠
- p.Pro94Leu Single submitter
- p.Ser104Ala Single submitter ⚠
- p.Ser123fs Single submitter
- p.Ser176Arg Single submitter ⚠
- p.Ser210Thr Single submitter ⚠
- p.Ser232Phe Single submitter ⚠
- p.Ser235Phe Single submitter ⚠
- p.Ser249Leu Single submitter
- p.Ser258Phe Single submitter ⚠
- p.Ser26Arg Single submitter ⚠
- p.Ser292Asn Single submitter ⚠
- p.Ser296Arg Single submitter ⚠
- p.Ser296Ile Single submitter ⚠
- p.Ser364Thr Single submitter ⚠
- p.Ser400Asn Single submitter ⚠
- p.Ser69Cys Single submitter ⚠
- p.Ser69Pro Single submitter ⚠
- p.Thr116Pro Single submitter ⚠
- p.Thr216Ala Single submitter ⚠
- p.Thr238Met Single submitter ⚠
- p.Thr287Arg Single submitter ⚠
- p.Thr390Met Single submitter ⚠
- p.Thr392Met Single submitter ⚠
- p.Thr424fs Single submitter
- p.Thr475Ala Single submitter ⚠
- p.Thr86Pro Single submitter ⚠
- p.Tyr180_Gln181delinsTer Single submitter
- p.Tyr180Cys Single submitter ⚠
- p.Tyr229Asp Single submitter ⚠
- p.Tyr229His Single submitter ⚠
- p.Tyr229Phe Single submitter ⚠
- p.Val193Ile Single submitter ⚠
- p.Val220del Single submitter
- p.Val257Ile Single submitter ⚠
- p.Val262Leu Single submitter ⚠
- p.Val290Ile Single submitter ⚠
- p.Val301Ile Single submitter ⚠
- p.Val325Ile Single submitter ⚠
- p.Val333Met Single submitter ⚠