KLF5 — 58 ClinVar variants
All ClinVar germline KLF5 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 56 flagged for review →
1 Pathogenic · 1 Benign · 56 Uncertain significance
Full KLF5 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 56
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 48
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- KLF5 p.Ala185Ser Uncertain significance Single submitter
- KLF5 p.Ala259Val Uncertain significance Single submitter
- KLF5 p.Arg11Cys Uncertain significance Single submitter
- KLF5 p.Arg413Ser Uncertain significance Single submitter
- KLF5 p.Arg41Cys Uncertain significance Single submitter
- KLF5 p.Arg41Gly Uncertain significance Single submitter
- KLF5 p.Asn205Ser Uncertain significance Single submitter
- KLF5 p.Asn205Thr Uncertain significance Single submitter
- KLF5 p.Asn321His Uncertain significance Single submitter
- KLF5 p.Asn342Asp Uncertain significance Single submitter
- KLF5 p.Asn439Ser Uncertain significance Single submitter
- KLF5 p.Gln122Lys Uncertain significance Single submitter
- KLF5 p.Gln197Arg Uncertain significance Single submitter
- KLF5 p.Gln22Pro Uncertain significance Single submitter
- KLF5 p.Gln295Pro Uncertain significance Single submitter
- KLF5 p.Gln87Pro Uncertain significance Single submitter
- KLF5 p.Glu50Gly Uncertain significance Single submitter
- KLF5 p.Gly35Ala Uncertain significance Single submitter
- KLF5 p.Gly77Cys Uncertain significance Single submitter
- KLF5 p.His266Arg Uncertain significance Single submitter
- KLF5 p.His53Gln Uncertain significance Single submitter
- KLF5 p.His56Tyr Uncertain significance Single submitter
- KLF5 p.Ile105Thr Uncertain significance Single submitter
- KLF5 p.Ile105Val Uncertain significance Single submitter
- KLF5 p.Ile143Val Uncertain significance Single submitter
- KLF5 p.Ile332Val Uncertain significance Single submitter
- KLF5 p.Leu219Val Uncertain significance Single submitter
- KLF5 p.Lys404Arg Uncertain significance Single submitter
- KLF5 p.Lys94Gln Uncertain significance Single submitter
- KLF5 p.Pro14Ala Uncertain significance Single submitter
- KLF5 p.Pro179Leu Uncertain significance Single submitter
- KLF5 p.Pro19Ser Uncertain significance Single submitter
- KLF5 p.Pro222Leu Uncertain significance Single submitter
- KLF5 p.Pro240Ser Uncertain significance Single submitter
- KLF5 p.Pro25Leu Uncertain significance Single submitter
- KLF5 p.Pro271Leu Uncertain significance Single submitter
- KLF5 p.Pro58Leu Uncertain significance Single submitter
- KLF5 p.Pro70Leu Uncertain significance Single submitter
- KLF5 p.Pro70Ser Uncertain significance Single submitter
- KLF5 p.Pro73Leu Uncertain significance Single submitter
- KLF5 p.Pro73Ser Uncertain significance Single submitter
- KLF5 p.Pro81Leu Uncertain significance Single submitter
- KLF5 p.Pro82Leu Uncertain significance Single submitter
- KLF5 p.Ser241Thr Uncertain significance Single submitter
- KLF5 p.Ser9Asn Uncertain significance Single submitter
- KLF5 p.Thr285Ala Uncertain significance Single submitter
- KLF5 p.Thr298Ser Uncertain significance Single submitter
- KLF5 p.Val221Phe Uncertain significance Single submitter
Predictors split 8
The independent predictors disagree with each other — read with care.
- KLF5 p.Asp126Gly Uncertain significance Single submitter
- KLF5 p.Gln122Pro Uncertain significance Single submitter
- KLF5 p.Lys31Met Uncertain significance Single submitter
- KLF5 p.Met318Ile Uncertain significance Single submitter
- KLF5 p.Met8Arg Uncertain significance Single submitter
- KLF5 p.Phe46Leu Uncertain significance Single submitter
- KLF5 p.Pro312Leu Uncertain significance Single submitter
- KLF5 p.Thr381Ile Uncertain significance Single submitter
All KLF5 variants
Pathogenic 1
- p.Leu367Ter No assertion criteria dilated cardiomyopathy 1FF
Benign 1
- p.Met249Val Multiple submitters
Uncertain significance 56
- p.Ala185Ser Single submitter ⚠
- p.Ala259Val Single submitter ⚠
- p.Arg11Cys Single submitter ⚠
- p.Arg413Ser Single submitter ⚠
- p.Arg41Cys Single submitter ⚠
- p.Arg41Gly Single submitter ⚠
- p.Asn205Ser Single submitter ⚠
- p.Asn205Thr Single submitter ⚠
- p.Asn321His Single submitter ⚠
- p.Asn342Asp Single submitter ⚠
- p.Asn439Ser Single submitter ⚠
- p.Asp126Gly Single submitter ⚠
- p.Gln122Lys Single submitter ⚠
- p.Gln122Pro Single submitter ⚠
- p.Gln197Arg Single submitter ⚠
- p.Gln22Pro Single submitter ⚠
- p.Gln295Pro Single submitter ⚠
- p.Gln87Pro Single submitter ⚠
- p.Glu50Gly Single submitter ⚠
- p.Gly35Ala Single submitter ⚠
- p.Gly77Cys Single submitter ⚠
- p.His266Arg Single submitter ⚠
- p.His53Gln Single submitter ⚠
- p.His56Tyr Single submitter ⚠
- p.Ile105Thr Single submitter ⚠
- p.Ile105Val Single submitter ⚠
- p.Ile143Val Single submitter ⚠
- p.Ile332Val Single submitter ⚠
- p.Leu219Val Single submitter ⚠
- p.Lys31Met Single submitter ⚠
- p.Lys404Arg Single submitter ⚠
- p.Lys94Gln Single submitter ⚠
- p.Met318Ile Single submitter ⚠
- p.Met8Arg Single submitter ⚠
- p.Phe46Leu Single submitter ⚠
- p.Pro14Ala Single submitter ⚠
- p.Pro179Leu Single submitter ⚠
- p.Pro19Ser Single submitter ⚠
- p.Pro222Leu Single submitter ⚠
- p.Pro240Ser Single submitter ⚠
- p.Pro25Leu Single submitter ⚠
- p.Pro271Leu Single submitter ⚠
- p.Pro312Leu Single submitter ⚠
- p.Pro58Leu Single submitter ⚠
- p.Pro70Leu Single submitter ⚠
- p.Pro70Ser Single submitter ⚠
- p.Pro73Leu Single submitter ⚠
- p.Pro73Ser Single submitter ⚠
- p.Pro81Leu Single submitter ⚠
- p.Pro82Leu Single submitter ⚠
- p.Ser241Thr Single submitter ⚠
- p.Ser9Asn Single submitter ⚠
- p.Thr285Ala Single submitter ⚠
- p.Thr298Ser Single submitter ⚠
- p.Thr381Ile Single submitter ⚠
- p.Val221Phe Single submitter ⚠