Sugi Variant

Sugi Variant/KLF6

KLF6 — 26 ClinVar variants

All ClinVar germline KLF6 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 19 flagged for review →

6 Pathogenic · 3 Benign · 1 Benign/Likely benign · 1 Likely benign · 15 Uncertain significance

Full KLF6 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions

⚑ Evidence disagreements 19

Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.

Predictors vs ClinVar 4

ClinVar calls these pathogenic, but the computational predictors lean tolerated — the highest-value review flag.

Predictors lean, ClinVar uncertain 12

ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.

Predictors split 3

The independent predictors disagree with each other — read with care.

All KLF6 variants

Pathogenic 6

Benign 3

Benign/Likely benign 1

  • p.Arg201= Multiple submitters hypotensive disorder

Likely benign 1

Uncertain significance 15