KLHL6 — 69 ClinVar variants
All ClinVar germline KLHL6 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 58 flagged for review →
3 Likely benign · 66 Uncertain significance
Full KLHL6 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 58
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 49
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- KLHL6 p.Ala233Thr Uncertain significance Single submitter
- KLHL6 p.Ala25Pro Uncertain significance Single submitter
- KLHL6 p.Ala452Thr Uncertain significance Single submitter
- KLHL6 p.Ala524Ser Uncertain significance Single submitter
- KLHL6 p.Ala52Ser Uncertain significance Single submitter
- KLHL6 p.Ala52Val Uncertain significance Single submitter
- KLHL6 p.Arg144Gln Uncertain significance Single submitter
- KLHL6 p.Arg308Ser Uncertain significance Single submitter
- KLHL6 p.Arg411Leu Uncertain significance Single submitter
- KLHL6 p.Asn478Ser Uncertain significance Single submitter
- KLHL6 p.Asp225Asn Uncertain significance Single submitter
- KLHL6 p.Asp37Ala Uncertain significance Single submitter
- KLHL6 p.Cys284Ser Uncertain significance Single submitter
- KLHL6 p.Cys539Tyr Uncertain significance Single submitter
- KLHL6 p.Gln199Arg Uncertain significance Single submitter
- KLHL6 p.Glu237Gln Uncertain significance Single submitter
- KLHL6 p.Glu259Lys Uncertain significance Single submitter
- KLHL6 p.Glu363Gln Uncertain significance Single submitter
- KLHL6 p.Glu363Lys Uncertain significance Single submitter
- KLHL6 p.Glu439Gln Uncertain significance Single submitter
- KLHL6 p.Gly8Asp Uncertain significance Single submitter
- KLHL6 p.His245Gln Uncertain significance Single submitter
- KLHL6 p.His358Arg Uncertain significance Single submitter
- KLHL6 p.His389Arg Uncertain significance Single submitter
- KLHL6 p.Ile435Val Uncertain significance Single submitter
- KLHL6 p.Ile509Val Uncertain significance Single submitter
- KLHL6 p.Ile553Met Uncertain significance Single submitter
- KLHL6 p.Leu592Arg Uncertain significance Single submitter
- KLHL6 p.Lys190Thr Uncertain significance Single submitter
- KLHL6 p.Lys48Asn Uncertain significance Single submitter
- KLHL6 p.Met296Arg Uncertain significance Single submitter
- KLHL6 p.Met296Val Uncertain significance Single submitter
- KLHL6 p.Pro264Leu Uncertain significance Single submitter
- KLHL6 p.Pro26Arg Uncertain significance Single submitter
- KLHL6 p.Pro285Leu Uncertain significance Single submitter
- KLHL6 p.Pro354Leu Uncertain significance Single submitter
- KLHL6 p.Ser163Arg Uncertain significance Single submitter
- KLHL6 p.Ser224Asn Uncertain significance Single submitter
- KLHL6 p.Ser248Pro Uncertain significance Single submitter
- KLHL6 p.Ser32Pro Uncertain significance Single submitter
- KLHL6 p.Ser537Asn Uncertain significance Single submitter
- KLHL6 p.Ser84Phe Uncertain significance Single submitter
- KLHL6 p.Thr125Ile Uncertain significance Single submitter
- KLHL6 p.Thr125Ser Uncertain significance Single submitter
- KLHL6 p.Thr440Asn Uncertain significance Single submitter
- KLHL6 p.Val261Met Uncertain significance Single submitter
- KLHL6 p.Val619Ala Uncertain significance Single submitter
-
KLHL6 p.Leu90Val
Uncertain significance
No assertion criteria
Monoclonal B-Cell Lymphocytosis
-
KLHL6 p.Phe83Leu
Uncertain significance
No assertion criteria
Monoclonal B-Cell Lymphocytosis
Predictors split 9
The independent predictors disagree with each other — read with care.
- KLHL6 p.Arg156Trp Uncertain significance Single submitter
- KLHL6 p.Arg244Trp Uncertain significance Single submitter
- KLHL6 p.Asn150Lys Uncertain significance Single submitter
- KLHL6 p.Ile611Ser Uncertain significance Single submitter
- KLHL6 p.Met322Thr Uncertain significance Single submitter
- KLHL6 p.Phe271Tyr Uncertain significance Single submitter
- KLHL6 p.Pro581Leu Uncertain significance Single submitter
- KLHL6 p.Thr328Lys Uncertain significance Single submitter
- KLHL6 p.Val438Met Uncertain significance Single submitter
All KLHL6 variants
Likely benign 3
- p.Ala9Thr Single submitter
- p.Thr130= Single submitter
- p.Thr35Arg Single submitter
Uncertain significance 66
- p.Ala168Asp Single submitter
- p.Ala233Thr Single submitter ⚠
- p.Ala25Pro Single submitter ⚠
- p.Ala452Thr Single submitter ⚠
- p.Ala524Ser Single submitter ⚠
- p.Ala52Ser Single submitter ⚠
- p.Ala52Val Single submitter ⚠
- p.Arg144Gln Single submitter ⚠
- p.Arg156Trp Single submitter ⚠
- p.Arg244Trp Single submitter ⚠
- p.Arg308Ser Single submitter ⚠
- p.Arg411Leu Single submitter ⚠
- p.Asn150Lys Single submitter ⚠
- p.Asn478Ser Single submitter ⚠
- p.Asp159His Single submitter
- p.Asp225Asn Single submitter ⚠
- p.Asp37Ala Single submitter ⚠
- p.Cys284Ser Single submitter ⚠
- p.Cys539Tyr Single submitter ⚠
- p.Gln199Arg Single submitter ⚠
- p.Glu237Gln Single submitter ⚠
- p.Glu259Lys Single submitter ⚠
- p.Glu363Gln Single submitter ⚠
- p.Glu363Lys Single submitter ⚠
- p.Glu439Gln Single submitter ⚠
- p.Gly8Asp Single submitter ⚠
- p.His245Gln Single submitter ⚠
- p.His358Arg Single submitter ⚠
- p.His389Arg Single submitter ⚠
- p.Ile435Val Single submitter ⚠
- p.Ile509Val Single submitter ⚠
- p.Ile553Met Single submitter ⚠
- p.Ile611Ser Single submitter ⚠
- p.Leu592Arg Single submitter ⚠
- p.Lys190Thr Single submitter ⚠
- p.Lys48Asn Single submitter ⚠
- p.Met296Arg Single submitter ⚠
- p.Met296Val Single submitter ⚠
- p.Met322Thr Single submitter ⚠
- p.Phe271Tyr Single submitter ⚠
- p.Pro255Leu Single submitter
- p.Pro264Leu Single submitter ⚠
- p.Pro26Arg Single submitter ⚠
- p.Pro285Leu Single submitter ⚠
- p.Pro354Leu Single submitter ⚠
- p.Pro581Leu Single submitter ⚠
- p.Ser163Arg Single submitter ⚠
- p.Ser207Pro Single submitter
- p.Ser224Asn Single submitter ⚠
- p.Ser248Pro Single submitter ⚠
- p.Ser306Leu Single submitter
- p.Ser32Pro Single submitter ⚠
- p.Ser537Asn Single submitter ⚠
- p.Ser84Phe Single submitter ⚠
- p.Thr125Ile Single submitter ⚠
- p.Thr125Ser Single submitter ⚠
- p.Thr130Met Single submitter
- p.Thr328Lys Single submitter ⚠
- p.Thr440Asn Single submitter ⚠
- p.Val239Met Single submitter
- p.Val261Met Single submitter ⚠
- p.Val373Ala Single submitter
- p.Val438Met Single submitter ⚠
- p.Val619Ala Single submitter ⚠
- p.Leu90Val No assertion criteria Monoclonal B-Cell Lymphocytosis ⚠
- p.Phe83Leu No assertion criteria Monoclonal B-Cell Lymphocytosis ⚠