KLK3 — 62 ClinVar variants
All ClinVar germline KLK3 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 36 flagged for review →
13 Benign · 11 Likely benign · 38 Uncertain significance
Full KLK3 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 36
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 26
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- KLK3 p.Ala135Thr Uncertain significance Single submitter
- KLK3 p.Ala18Thr Uncertain significance Single submitter
- KLK3 p.Asn108Thr Uncertain significance Single submitter
- KLK3 p.Asp182Val Uncertain significance Single submitter
- KLK3 p.Asp212Asn Uncertain significance Single submitter
- KLK3 p.Cys173Tyr Uncertain significance Single submitter
- KLK3 p.Cys198Phe Uncertain significance Single submitter
- KLK3 p.Cys66Arg Uncertain significance Single submitter
- KLK3 p.Gly230Asp Uncertain significance Single submitter
- KLK3 p.Gly28Val Uncertain significance Single submitter
- KLK3 p.Gly52Ser Uncertain significance Single submitter
- KLK3 p.His248Pro Uncertain significance Single submitter
- KLK3 p.His78Gln Uncertain significance Single submitter
- KLK3 p.Leu123Gln Uncertain significance Single submitter
- KLK3 p.Leu176Phe Uncertain significance Single submitter
- KLK3 p.Leu223Phe Uncertain significance Single submitter
- KLK3 p.Phe165Ser Uncertain significance Single submitter
- KLK3 p.Pro37His Uncertain significance Single submitter
- KLK3 p.Thr13Met Uncertain significance Single submitter
- KLK3 p.Trp157Cys Uncertain significance Single submitter
- KLK3 p.Trp2Gly Uncertain significance Single submitter
- KLK3 p.Val183Leu Uncertain significance Single submitter
- KLK3 p.Val192Leu Uncertain significance Single submitter
- KLK3 p.Val258Leu Uncertain significance Single submitter
- KLK3 p.Val49Leu Uncertain significance Single submitter
- KLK3 p.Val55Gly Uncertain significance Single submitter
Predictors split 10
The independent predictors disagree with each other — read with care.
- KLK3 p.Ala43Asp Uncertain significance Single submitter
- KLK3 p.Gly114Cys Uncertain significance Single submitter
- KLK3 p.Gly114Val Uncertain significance Single submitter
- KLK3 p.Gly221Arg Uncertain significance Single submitter
- KLK3 p.Gly87Asp Uncertain significance Single submitter
- KLK3 p.His56Arg Uncertain significance Single submitter
- KLK3 p.Pro57Leu Uncertain significance Single submitter
- KLK3 p.Thr133Met Uncertain significance Single submitter
- KLK3 p.Thr227Met Uncertain significance Single submitter
- KLK3 p.Trp202Cys Uncertain significance Single submitter
All KLK3 variants
Benign 13
- c.*15C>T Multiple submitters
- p.Glu32Lys Multiple submitters
- p.Thr227= Multiple submitters
- p.Gln39Leu Single submitter
- c.631-424G>A No assertion criteria KLK3-related disorder
- c.631-425C>T No assertion criteria KLK3-related disorder
- p.Ala18= No assertion criteria KLK3-related disorder
- p.Arg125Cys No assertion criteria KLK3-related disorder
- p.Gln39= No assertion criteria KLK3-related disorder
- p.Gly16= No assertion criteria KLK3-related disorder
- p.Leu132Ile No assertion criteria KLK3-related disorder
- p.Pro233= No assertion criteria KLK3-related disorder
- p.Ser79= No assertion criteria KLK3-related disorder
Likely benign 11
- p.Arg109Gln Single submitter
- p.Arg201His Single submitter
- p.Arg45His Single submitter
- p.His177= Single submitter
- p.Trp202Leu Single submitter
- c.47-9C>G No assertion criteria KLK3-related disorder
- p.Gly149= No assertion criteria KLK3-related disorder
- p.Gly215= No assertion criteria KLK3-related disorder
- p.His119= No assertion criteria KLK3-related disorder
- p.Ser210Trp No assertion criteria KLK3-related disorder
- p.Tyr153= No assertion criteria KLK3-related disorder
Uncertain significance 38
- p.Ala135Thr Single submitter ⚠
- p.Ala18Thr Single submitter ⚠
- p.Ala43Asp Single submitter ⚠
- p.Arg201Cys Single submitter
- p.Arg24Gln Single submitter
- p.Asn108Thr Single submitter ⚠
- p.Asp182Val Single submitter ⚠
- p.Asp212Asn Single submitter ⚠
- p.Cys173Tyr Single submitter ⚠
- p.Cys198Phe Single submitter ⚠
- p.Cys66Arg Single submitter ⚠
- p.Gly114Cys Single submitter ⚠
- p.Gly114Val Single submitter ⚠
- p.Gly221Arg Single submitter ⚠
- p.Gly230Asp Single submitter ⚠
- p.Gly28Val Single submitter ⚠
- p.Gly52Ser Single submitter ⚠
- p.Gly87Asp Single submitter ⚠
- p.His248Pro Single submitter ⚠
- p.His56Arg Single submitter ⚠
- p.His78Gln Single submitter ⚠
- p.Leu123Gln Single submitter ⚠
- p.Leu176Phe Single submitter ⚠
- p.Leu223Phe Single submitter ⚠
- p.Phe165Ser Single submitter ⚠
- p.Pro37His Single submitter ⚠
- p.Pro57Leu Single submitter ⚠
- p.Thr133Met Single submitter ⚠
- p.Thr13Met Single submitter ⚠
- p.Thr227Met Single submitter ⚠
- p.Trp157Cys Single submitter ⚠
- p.Trp202Cys Single submitter ⚠
- p.Trp2Gly Single submitter ⚠
- p.Val183Leu Single submitter ⚠
- p.Val192Leu Single submitter ⚠
- p.Val258Leu Single submitter ⚠
- p.Val49Leu Single submitter ⚠
- p.Val55Gly Single submitter ⚠