KLK5 — 47 ClinVar variants
All ClinVar germline KLK5 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 37 flagged for review →
5 Likely benign · 42 Uncertain significance
Full KLK5 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 37
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 31
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- KLK5 p.Ala54Val Uncertain significance Single submitter
- KLK5 p.Ala83Ser Uncertain significance Single submitter
- KLK5 p.Arg161Gly Uncertain significance Single submitter
- KLK5 p.Arg170Gly Uncertain significance Single submitter
- KLK5 p.Arg223Lys Uncertain significance Single submitter
- KLK5 p.Asn208Ser Uncertain significance Single submitter
- KLK5 p.Asn252Lys Uncertain significance Single submitter
- KLK5 p.Asp226Asn Uncertain significance Single submitter
- KLK5 p.Asp72Asn Uncertain significance Single submitter
- KLK5 p.Gly119Ser Uncertain significance Single submitter
- KLK5 p.Gly149Ser Uncertain significance Single submitter
- KLK5 p.Gly22Val Uncertain significance Single submitter
- KLK5 p.Gly243Ser Uncertain significance Single submitter
- KLK5 p.Gly246Arg Uncertain significance Single submitter
- KLK5 p.Gly273Asp Uncertain significance Single submitter
- KLK5 p.Gly51Glu Uncertain significance Single submitter
- KLK5 p.His76Tyr Uncertain significance Single submitter
- KLK5 p.Ile16Met Uncertain significance Single submitter
- KLK5 p.Leu12Pro Uncertain significance Single submitter
- KLK5 p.Leu20Val Uncertain significance Single submitter
- KLK5 p.Lys167Arg Uncertain significance Single submitter
- KLK5 p.Lys194Glu Uncertain significance Single submitter
- KLK5 p.Pro141Ala Uncertain significance Single submitter
- KLK5 p.Pro272Ser Uncertain significance Single submitter
- KLK5 p.Pro6Ser Uncertain significance Single submitter
- KLK5 p.Ser46Arg Uncertain significance Single submitter
- KLK5 p.Thr17Ala Uncertain significance Single submitter
- KLK5 p.Trp80Arg Uncertain significance Single submitter
- KLK5 p.Val169Gly Uncertain significance Single submitter
- KLK5 p.Val23Asp Uncertain significance Single submitter
- KLK5 p.Val98Ala Uncertain significance Single submitter
Predictors split 6
The independent predictors disagree with each other — read with care.
- KLK5 p.Ala267Ser Uncertain significance Single submitter
- KLK5 p.Arg117Cys Uncertain significance Single submitter
- KLK5 p.Arg268Trp Uncertain significance Single submitter
- KLK5 p.Asn152Asp Uncertain significance Single submitter
- KLK5 p.Gln242Arg Uncertain significance Single submitter
- KLK5 p.Val137Phe Uncertain significance Single submitter
All KLK5 variants
Likely benign 5
- p.Arg164His Single submitter
- p.Arg268Gln Single submitter
- p.Glu218Lys Single submitter
- p.His26Arg Single submitter
- p.Val33Ala Single submitter
Uncertain significance 42
- p.Ala267Ser Single submitter ⚠
- p.Ala54Val Single submitter ⚠
- p.Ala83Ser Single submitter ⚠
- p.Arg117Cys Single submitter ⚠
- p.Arg161Gly Single submitter ⚠
- p.Arg170Gly Single submitter ⚠
- p.Arg223Lys Single submitter ⚠
- p.Arg268Trp Single submitter ⚠
- p.Asn152Asp Single submitter ⚠
- p.Asn208Ser Single submitter ⚠
- p.Asn252Lys Single submitter ⚠
- p.Asp226Asn Single submitter ⚠
- p.Asp226Gly Single submitter
- p.Asp72Asn Single submitter ⚠
- p.Gln242Arg Single submitter ⚠
- p.Gly119Ser Single submitter ⚠
- p.Gly149Ser Single submitter ⚠
- p.Gly22Val Single submitter ⚠
- p.Gly243Ser Single submitter ⚠
- p.Gly246Arg Single submitter ⚠
- p.Gly273Asp Single submitter ⚠
- p.Gly51Glu Single submitter ⚠
- p.His76Tyr Single submitter ⚠
- p.Ile16Met Single submitter ⚠
- p.Leu12Pro Single submitter ⚠
- p.Leu20Val Single submitter ⚠
- p.Lys167Arg Single submitter ⚠
- p.Lys194Glu Single submitter ⚠
- p.Pro141Ala Single submitter ⚠
- p.Pro148Arg Single submitter
- p.Pro222Leu Single submitter
- p.Pro222Ser Single submitter
- p.Pro272Ser Single submitter ⚠
- p.Pro6Ser Single submitter ⚠
- p.Ser46Arg Single submitter ⚠
- p.Ser64Arg Single submitter
- p.Thr17Ala Single submitter ⚠
- p.Trp80Arg Single submitter ⚠
- p.Val137Phe Single submitter ⚠
- p.Val169Gly Single submitter ⚠
- p.Val23Asp Single submitter ⚠
- p.Val98Ala Single submitter ⚠