KLK6 — 28 ClinVar variants
All ClinVar germline KLK6 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 25 flagged for review →
1 Benign · 2 Likely benign · 25 Uncertain significance
Full KLK6 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 25
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 19
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- KLK6 p.Ala101Thr Uncertain significance Single submitter
- KLK6 p.Ala101Val Uncertain significance Single submitter
- KLK6 p.Ala113Thr Uncertain significance Single submitter
- KLK6 p.Ala116Thr Uncertain significance Single submitter
- KLK6 p.Ala171Val Uncertain significance Single submitter
- KLK6 p.Arg165His Uncertain significance Single submitter
- KLK6 p.Asn235Lys Uncertain significance Single submitter
- KLK6 p.Asp29Asn Uncertain significance Single submitter
- KLK6 p.Gln238His Uncertain significance Single submitter
- KLK6 p.Glu18Lys Uncertain significance Single submitter
- KLK6 p.Gly214Asp Uncertain significance Single submitter
- KLK6 p.Gly225Glu Uncertain significance Single submitter
- KLK6 p.Gly26Arg Uncertain significance Single submitter
- KLK6 p.Leu127Pro Uncertain significance Single submitter
- KLK6 p.Pro126Leu Uncertain significance Single submitter
- KLK6 p.Ser137Asn Uncertain significance Single submitter
- KLK6 p.Ser197Phe Uncertain significance Single submitter
- KLK6 p.Thr59Ile Uncertain significance Single submitter
- KLK6 p.Val89Leu Uncertain significance Single submitter
Predictors split 6
The independent predictors disagree with each other — read with care.
- KLK6 p.Arg78Trp Benign Multiple submitters
- KLK6 p.Arg91Trp Uncertain significance Single submitter
- KLK6 p.Gln156Arg Uncertain significance Single submitter
- KLK6 p.Leu39Val Uncertain significance Single submitter
- KLK6 p.Pro173Ser Uncertain significance Single submitter
- KLK6 p.Ser83Phe Likely benign Single submitter
All KLK6 variants
Benign 1
- p.Arg78Trp Multiple submitters ⚠
Likely benign 2
- p.Arg78Gln Single submitter
- p.Ser83Phe Single submitter ⚠
Uncertain significance 25
- p.Ala101Thr Single submitter ⚠
- p.Ala101Val Single submitter ⚠
- p.Ala113Thr Single submitter ⚠
- p.Ala116Thr Single submitter ⚠
- p.Ala171Val Single submitter ⚠
- p.Arg114Cys Single submitter
- p.Arg165His Single submitter ⚠
- p.Arg91Trp Single submitter ⚠
- p.Asn235Lys Single submitter ⚠
- p.Asp29Asn Single submitter ⚠
- p.Gln156Arg Single submitter ⚠
- p.Gln238His Single submitter ⚠
- p.Glu18Lys Single submitter ⚠
- p.Gly214Asp Single submitter ⚠
- p.Gly225Glu Single submitter ⚠
- p.Gly26Arg Single submitter ⚠
- p.Leu127Pro Single submitter ⚠
- p.Leu39Val Single submitter ⚠
- p.Pro126Leu Single submitter ⚠
- p.Pro173Ser Single submitter ⚠
- p.Pro217Ser Single submitter
- p.Ser137Asn Single submitter ⚠
- p.Ser197Phe Single submitter ⚠
- p.Thr59Ile Single submitter ⚠
- p.Val89Leu Single submitter ⚠