KLK7 — 50 ClinVar variants
All ClinVar germline KLK7 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 44 flagged for review →
4 Benign · 46 Uncertain significance
Full KLK7 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 44
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 38
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- KLK7 p.Thr153Met Uncertain significance Multiple submitters
- KLK7 p.Ala191Val Uncertain significance Single submitter
- KLK7 p.Ala68Thr Uncertain significance Single submitter
- KLK7 p.Arg63Cys Uncertain significance Single submitter
- KLK7 p.Arg63Pro Uncertain significance Single submitter
- KLK7 p.Arg92Thr Uncertain significance Single submitter
- KLK7 p.Asn51His Uncertain significance Single submitter
- KLK7 p.Asn61Ser Uncertain significance Single submitter
- KLK7 p.Asp156Glu Uncertain significance Single submitter
- KLK7 p.Asp195Ala Uncertain significance Single submitter
- KLK7 p.Asp87Glu Uncertain significance Single submitter
- KLK7 p.Cys144Gly Uncertain significance Single submitter
- KLK7 p.Cys165Ser Uncertain significance Single submitter
- KLK7 p.Glu138Lys Uncertain significance Single submitter
- KLK7 p.Gly103Ala Uncertain significance Single submitter
- KLK7 p.Gly103Ser Uncertain significance Single submitter
- KLK7 p.Gly148Ser Uncertain significance Single submitter
- KLK7 p.Gly217Ser Uncertain significance Single submitter
- KLK7 p.Ile245Thr Uncertain significance Single submitter
- KLK7 p.Leu170Ile Uncertain significance Single submitter
- KLK7 p.Leu183Ser Uncertain significance Single submitter
- KLK7 p.Lys178Arg Uncertain significance Single submitter
- KLK7 p.Lys197Arg Uncertain significance Single submitter
- KLK7 p.Lys197Asn Uncertain significance Single submitter
- KLK7 p.Lys243Asn Uncertain significance Single submitter
- KLK7 p.Lys251Asn Uncertain significance Single submitter
- KLK7 p.Met114Thr Uncertain significance Single submitter
- KLK7 p.Pro139Ser Uncertain significance Single submitter
- KLK7 p.Pro140Ala Uncertain significance Single submitter
- KLK7 p.Pro8Leu Uncertain significance Single submitter
- KLK7 p.Ser126Pro Uncertain significance Single submitter
- KLK7 p.Ser172Cys Uncertain significance Single submitter
- KLK7 p.Ser98Ala Uncertain significance Single submitter
- KLK7 p.Thr177Arg Uncertain significance Single submitter
- KLK7 p.Trp43Arg Uncertain significance Single submitter
- KLK7 p.Val110Ile Uncertain significance Single submitter
- KLK7 p.Val45Ala Uncertain significance Single submitter
- KLK7 p.Val78Met Uncertain significance Single submitter
Predictors split 6
The independent predictors disagree with each other — read with care.
- KLK7 p.Asn199His Uncertain significance Single submitter
- KLK7 p.Cys176Ser Uncertain significance Single submitter
- KLK7 p.Leu53Pro Uncertain significance Single submitter
- KLK7 p.Leu9Gln Uncertain significance Single submitter
- KLK7 p.Pro208Leu Uncertain significance Single submitter
- KLK7 p.Val166Met Uncertain significance Single submitter
All KLK7 variants
Benign 4
- p.Cys226= Multiple submitters
- p.Pro208= Multiple submitters
- p.Ser147= Multiple submitters
- p.Thr242Ile Multiple submitters
Uncertain significance 46
- p.Thr153Met Multiple submitters ⚠
- p.Ala191Val Single submitter ⚠
- p.Ala68Thr Single submitter ⚠
- p.Arg63Cys Single submitter ⚠
- p.Arg63Pro Single submitter ⚠
- p.Arg92Thr Single submitter ⚠
- p.Asn199His Single submitter ⚠
- p.Asn51His Single submitter ⚠
- p.Asn61Ser Single submitter ⚠
- p.Asp156Glu Single submitter ⚠
- p.Asp195Ala Single submitter ⚠
- p.Asp87Glu Single submitter ⚠
- p.Cys144Gly Single submitter ⚠
- p.Cys165Ser Single submitter ⚠
- p.Cys176Ser Single submitter ⚠
- p.Glu138Lys Single submitter ⚠
- p.Gly103Ala Single submitter ⚠
- p.Gly103Ser Single submitter ⚠
- p.Gly148Ser Single submitter ⚠
- p.Gly217Ser Single submitter ⚠
- p.Gly39Arg Single submitter
- p.Ile245Thr Single submitter ⚠
- p.Leu170Ile Single submitter ⚠
- p.Leu183Ser Single submitter ⚠
- p.Leu53Pro Single submitter ⚠
- p.Leu9Gln Single submitter ⚠
- p.Lys178Arg Single submitter ⚠
- p.Lys197Arg Single submitter ⚠
- p.Lys197Asn Single submitter ⚠
- p.Lys240Asn Single submitter
- p.Lys243Asn Single submitter ⚠
- p.Lys251Asn Single submitter ⚠
- p.Met114Thr Single submitter ⚠
- p.Pro139Ser Single submitter ⚠
- p.Pro140Ala Single submitter ⚠
- p.Pro208Leu Single submitter ⚠
- p.Pro8Leu Single submitter ⚠
- p.Ser126Pro Single submitter ⚠
- p.Ser172Cys Single submitter ⚠
- p.Ser98Ala Single submitter ⚠
- p.Thr177Arg Single submitter ⚠
- p.Trp43Arg Single submitter ⚠
- p.Val110Ile Single submitter ⚠
- p.Val166Met Single submitter ⚠
- p.Val45Ala Single submitter ⚠
- p.Val78Met Single submitter ⚠