KLK8 — 52 ClinVar variants
All ClinVar germline KLK8 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 34 flagged for review →
7 Likely benign · 45 Uncertain significance
Full KLK8 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 34
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 27
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- KLK8 p.Ala48Val Uncertain significance Single submitter
- KLK8 p.Ala8Ser Uncertain significance Single submitter
- KLK8 p.Arg27Gly Uncertain significance Single submitter
- KLK8 p.Arg5Gln Uncertain significance Single submitter
- KLK8 p.Arg7Pro Uncertain significance Single submitter
- KLK8 p.Asn244Asp Uncertain significance Single submitter
- KLK8 p.Asp250Ala Uncertain significance Single submitter
- KLK8 p.Cys208Tyr Uncertain significance Single submitter
- KLK8 p.Gln129His Uncertain significance Single submitter
- KLK8 p.Gln54Arg Uncertain significance Single submitter
- KLK8 p.Glu185Lys Uncertain significance Single submitter
- KLK8 p.Gly190Glu Uncertain significance Single submitter
- KLK8 p.Gly19Arg Uncertain significance Single submitter
- KLK8 p.Ile104Val Uncertain significance Single submitter
- KLK8 p.Lys151Gln Uncertain significance Single submitter
- KLK8 p.Lys253Arg Uncertain significance Single submitter
- KLK8 p.Lys254Thr Uncertain significance Single submitter
- KLK8 p.Met13Thr Uncertain significance Single submitter
- KLK8 p.Pro41Ser Uncertain significance Single submitter
- KLK8 p.Pro4His Uncertain significance Single submitter
- KLK8 p.Pro4Thr Uncertain significance Single submitter
- KLK8 p.Ser111Gly Uncertain significance Single submitter
- KLK8 p.Ser112Asn Uncertain significance Single submitter
- KLK8 p.Ser202Gly Uncertain significance Single submitter
- KLK8 p.Thr170Ser Uncertain significance Single submitter
- KLK8 p.Val114Met Uncertain significance Single submitter
- KLK8 p.Val33Ala Uncertain significance Single submitter
Predictors split 7
The independent predictors disagree with each other — read with care.
- KLK8 p.Asp237Tyr Uncertain significance Single submitter
- KLK8 p.Gly149Ser Uncertain significance Single submitter
- KLK8 p.Gly220Ser Uncertain significance Single submitter
- KLK8 p.Leu123Val Uncertain significance Single submitter
- KLK8 p.Pro148His Uncertain significance Single submitter
- KLK8 p.Pro189Ser Uncertain significance Single submitter
- KLK8 p.Thr159Ala Uncertain significance Single submitter
All KLK8 variants
Likely benign 7
- c.71-127A>T Single submitter
- c.71-87C>T Single submitter
- p.Asp113Asn Single submitter
- p.Asp237Glu Single submitter
- p.Gly210= Single submitter
- p.Gly214= Single submitter
- p.Ser140Asn Single submitter
Uncertain significance 45
- c.71-114T>C Single submitter
- c.71-132G>A Single submitter
- c.71-132G>T Single submitter
- c.71-18C>G Single submitter
- c.71-51C>T Single submitter
- c.71-63G>C Single submitter
- c.71-97G>A Single submitter
- c.71-99C>T Single submitter
- p.Ala48Val Single submitter ⚠
- p.Ala8Ser Single submitter ⚠
- p.Arg127Cys Single submitter
- p.Arg127Pro Single submitter
- p.Arg27Gly Single submitter ⚠
- p.Arg5Gln Single submitter ⚠
- p.Arg7Pro Single submitter ⚠
- p.Asn244Asp Single submitter ⚠
- p.Asp237Tyr Single submitter ⚠
- p.Asp250Ala Single submitter ⚠
- p.Cys208Tyr Single submitter ⚠
- p.Gln129His Single submitter ⚠
- p.Gln54Arg Single submitter ⚠
- p.Glu185Lys Single submitter ⚠
- p.Gly149Ser Single submitter ⚠
- p.Gly190Glu Single submitter ⚠
- p.Gly19Arg Single submitter ⚠
- p.Gly220Ser Single submitter ⚠
- p.Ile104Val Single submitter ⚠
- p.Leu123Val Single submitter ⚠
- p.Lys151Gln Single submitter ⚠
- p.Lys253Arg Single submitter ⚠
- p.Lys254Thr Single submitter ⚠
- p.Met13Thr Single submitter ⚠
- p.Pro148His Single submitter ⚠
- p.Pro189Ser Single submitter ⚠
- p.Pro232Arg Single submitter
- p.Pro41Ser Single submitter ⚠
- p.Pro4His Single submitter ⚠
- p.Pro4Thr Single submitter ⚠
- p.Ser111Gly Single submitter ⚠
- p.Ser112Asn Single submitter ⚠
- p.Ser202Gly Single submitter ⚠
- p.Thr159Ala Single submitter ⚠
- p.Thr170Ser Single submitter ⚠
- p.Val114Met Single submitter ⚠
- p.Val33Ala Single submitter ⚠