KPNA2 — 33 ClinVar variants
All ClinVar germline KPNA2 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 28 flagged for review →
2 Benign · 1 Likely benign · 30 Uncertain significance
Full KPNA2 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 28
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 24
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- KPNA2 p.Ala143Val Uncertain significance Single submitter
- KPNA2 p.Ala176Val Uncertain significance Single submitter
- KPNA2 p.Ala243Thr Uncertain significance Single submitter
- KPNA2 p.Ala60Thr Uncertain significance Single submitter
- KPNA2 p.Arg197Gln Uncertain significance Single submitter
- KPNA2 p.Asn346Thr Uncertain significance Single submitter
- KPNA2 p.Asn505Tyr Uncertain significance Single submitter
- KPNA2 p.Gln71Leu Uncertain significance Single submitter
- KPNA2 p.Glu499Lys Uncertain significance Single submitter
- KPNA2 p.Glu66Asp Uncertain significance Single submitter
- KPNA2 p.Ile121Val Uncertain significance Single submitter
- KPNA2 p.Ile178Val Uncertain significance Single submitter
- KPNA2 p.Lys123Arg Uncertain significance Single submitter
- KPNA2 p.Lys435Arg Uncertain significance Single submitter
- KPNA2 p.Pro122Leu Uncertain significance Single submitter
- KPNA2 p.Ser387Cys Uncertain significance Single submitter
- KPNA2 p.Ser54Asn Uncertain significance Single submitter
- KPNA2 p.Thr131Ser Uncertain significance Single submitter
- KPNA2 p.Thr271Ile Uncertain significance Single submitter
- KPNA2 p.Thr61Ala Uncertain significance Single submitter
- KPNA2 p.Thr61Ile Uncertain significance Single submitter
- KPNA2 p.Thr73Ile Uncertain significance Single submitter
- KPNA2 p.Tyr415Phe Uncertain significance Single submitter
- KPNA2 p.Val195Gly Uncertain significance Single submitter
Predictors split 4
The independent predictors disagree with each other — read with care.
All KPNA2 variants
Likely benign 1
- p.Pro347Ser Single submitter
Uncertain significance 30
- p.Ala143Val Single submitter ⚠
- p.Ala176Val Single submitter ⚠
- p.Ala243Thr Single submitter ⚠
- p.Ala60Thr Single submitter ⚠
- p.Arg13His Single submitter ⚠
- p.Arg197Gln Single submitter ⚠
- p.Asn346Ile Single submitter
- p.Asn346Thr Single submitter ⚠
- p.Asn505Tyr Single submitter ⚠
- p.Asp79Val Single submitter ⚠
- p.Gln71Leu Single submitter ⚠
- p.Glu499Lys Single submitter ⚠
- p.Glu66Asp Single submitter ⚠
- p.Ile121Val Single submitter ⚠
- p.Ile178Val Single submitter ⚠
- p.Lys123Arg Single submitter ⚠
- p.Lys435Arg Single submitter ⚠
- p.Pro122Leu Single submitter ⚠
- p.Pro63Leu Single submitter ⚠
- p.Ser387Cys Single submitter ⚠
- p.Ser512Phe Single submitter ⚠
- p.Ser54Asn Single submitter ⚠
- p.Thr131Ser Single submitter ⚠
- p.Thr271Ile Single submitter ⚠
- p.Thr61Ala Single submitter ⚠
- p.Thr61Ile Single submitter ⚠
- p.Thr73Ile Single submitter ⚠
- p.Tyr415Phe Single submitter ⚠
- p.Val195Gly Single submitter ⚠
- p.Val401Met Single submitter