KPNA6 — 33 ClinVar variants
All ClinVar germline KPNA6 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 32 flagged for review →
33 Uncertain significance
Full KPNA6 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 32
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 23
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- KPNA6 p.Ala61Ser Uncertain significance Single submitter
- KPNA6 p.Arg135Lys Uncertain significance Single submitter
- KPNA6 p.Arg228Gln Uncertain significance Single submitter
- KPNA6 p.Arg259His Uncertain significance Single submitter
- KPNA6 p.Arg450Gln Uncertain significance Single submitter
- KPNA6 p.Asn11Ser Uncertain significance Single submitter
- KPNA6 p.Asn136His Uncertain significance Single submitter
- KPNA6 p.Asn367Ser Uncertain significance Single submitter
- KPNA6 p.Asn378Ser Uncertain significance Single submitter
- KPNA6 p.Asp117Asn Uncertain significance Single submitter
- KPNA6 p.Asp92Asn Uncertain significance Single submitter
- KPNA6 p.Cys253Tyr Uncertain significance Single submitter
- KPNA6 p.Glu532Asp Uncertain significance Single submitter
- KPNA6 p.Ile352Val Uncertain significance Single submitter
- KPNA6 p.Ile375Val Uncertain significance Single submitter
- KPNA6 p.Leu211Ile Uncertain significance Single submitter
- KPNA6 p.Leu279Met Uncertain significance Single submitter
- KPNA6 p.Lys424Asn Uncertain significance Single submitter
- KPNA6 p.Met4Val Uncertain significance Single submitter
- KPNA6 p.Pro381Arg Uncertain significance Single submitter
- KPNA6 p.Ser178Leu Uncertain significance Single submitter
- KPNA6 p.Ser510Ile Uncertain significance Single submitter
- KPNA6 p.Val463Ile Uncertain significance Single submitter
Predictors split 9
The independent predictors disagree with each other — read with care.
- KPNA6 p.Ala168Ser Uncertain significance Single submitter
- KPNA6 p.Arg128Gln Uncertain significance Single submitter
- KPNA6 p.Asp507Asn Uncertain significance Single submitter
- KPNA6 p.Glu455Gln Uncertain significance Single submitter
- KPNA6 p.Ile321Val Uncertain significance Single submitter
- KPNA6 p.Ile375Thr Uncertain significance Single submitter
- KPNA6 p.Lys349Arg Uncertain significance Single submitter
- KPNA6 p.Met85Ile Uncertain significance Single submitter
- KPNA6 p.Val80Gly Uncertain significance Single submitter
All KPNA6 variants
Uncertain significance 33
- p.Ala168Ser Single submitter ⚠
- p.Ala61Ser Single submitter ⚠
- p.Arg128Gln Single submitter ⚠
- p.Arg135Lys Single submitter ⚠
- p.Arg228Gln Single submitter ⚠
- p.Arg259His Single submitter ⚠
- p.Arg368fs Single submitter
- p.Arg450Gln Single submitter ⚠
- p.Asn11Ser Single submitter ⚠
- p.Asn136His Single submitter ⚠
- p.Asn367Ser Single submitter ⚠
- p.Asn378Ser Single submitter ⚠
- p.Asp117Asn Single submitter ⚠
- p.Asp507Asn Single submitter ⚠
- p.Asp92Asn Single submitter ⚠
- p.Cys253Tyr Single submitter ⚠
- p.Glu455Gln Single submitter ⚠
- p.Glu532Asp Single submitter ⚠
- p.Ile321Val Single submitter ⚠
- p.Ile352Val Single submitter ⚠
- p.Ile375Thr Single submitter ⚠
- p.Ile375Val Single submitter ⚠
- p.Leu211Ile Single submitter ⚠
- p.Leu279Met Single submitter ⚠
- p.Lys349Arg Single submitter ⚠
- p.Lys424Asn Single submitter ⚠
- p.Met4Val Single submitter ⚠
- p.Met85Ile Single submitter ⚠
- p.Pro381Arg Single submitter ⚠
- p.Ser178Leu Single submitter ⚠
- p.Ser510Ile Single submitter ⚠
- p.Val463Ile Single submitter ⚠
- p.Val80Gly Single submitter ⚠