Sugi Variant

Sugi Variant/KRT4

KRT4 — 198 ClinVar variants

All ClinVar germline KRT4 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 110 flagged for review →

3 Pathogenic · 14 Conflicting · 36 Benign · 9 Benign/Likely benign · 28 Likely benign · 108 Uncertain significance

Full KRT4 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions

⚑ Evidence disagreements 110

Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.

Predictors agree, ClinVar conflicts 10

ClinVar submitters conflict, but the independent predictors unanimously agree — a QC review flag, not a reclassification.

Predictors lean, ClinVar uncertain 56

ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.

Predictors split 44

The independent predictors disagree with each other — read with care.

All KRT4 variants

Pathogenic 3

Conflicting classifications of pathogenicity 14

Benign 36

Benign/Likely benign 9

Likely benign 28

Uncertain significance 108