Sugi Variant

Sugi Variant/KRT6A

KRT6A — 252 ClinVar variants

All ClinVar germline KRT6A variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 113 flagged for review →

15 Pathogenic · 4 Pathogenic/Likely pathogenic · 11 Likely pathogenic · 6 Conflicting · 32 Benign · 14 Benign/Likely benign · 48 Likely benign · 122 Uncertain significance

Full KRT6A gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions

⚑ Evidence disagreements 113

Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.

Predictors agree, ClinVar conflicts 6

ClinVar submitters conflict, but the independent predictors unanimously agree — a QC review flag, not a reclassification.

Predictors lean, ClinVar uncertain 74

ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.

Predictors split 33

The independent predictors disagree with each other — read with care.

All KRT6A variants

Pathogenic 15

Pathogenic/Likely pathogenic 4

Likely pathogenic 11

Conflicting classifications of pathogenicity 6

Benign 32

Benign/Likely benign 14

Likely benign 48

Uncertain significance 122