KRT8 — 81 ClinVar variants
All ClinVar germline KRT8 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 51 flagged for review →
8 Benign · 3 Benign/Likely benign · 17 Likely benign · 53 Uncertain significance
Full KRT8 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 51
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 38
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- KRT8 p.Ala334Thr Uncertain significance Single submitter
- KRT8 p.Ala351Thr Uncertain significance Single submitter
- KRT8 p.Ala86Val Uncertain significance Single submitter
- KRT8 p.Arg149Trp Uncertain significance Single submitter
- KRT8 p.Arg186Gly Uncertain significance Single submitter
- KRT8 p.Arg275Gln Uncertain significance Single submitter
- KRT8 p.Arg302His Uncertain significance Single submitter
- KRT8 p.Arg316Trp Uncertain significance Single submitter
- KRT8 p.Arg362Gln Uncertain significance Single submitter
- KRT8 p.Arg372Cys Uncertain significance Single submitter
- KRT8 p.Arg372His Uncertain significance Single submitter
- KRT8 p.Arg392Gly Uncertain significance Single submitter
- KRT8 p.Arg454Leu Uncertain significance Single submitter
- KRT8 p.Asn191Ser Uncertain significance Single submitter
- KRT8 p.Asn222Lys Uncertain significance Single submitter
- KRT8 p.Asp255His Uncertain significance Single submitter
- KRT8 p.Asp479Glu Uncertain significance Single submitter
- KRT8 p.Gln7Pro Uncertain significance Single submitter
- KRT8 p.Glu209Lys Uncertain significance Single submitter
- KRT8 p.Glu339Lys Uncertain significance Single submitter
- KRT8 p.Gly429Ser Uncertain significance Single submitter
- KRT8 p.Gly444Ser Uncertain significance Single submitter
-
KRT8 p.Gly471Glu
Uncertain significance
Single submitter
hepatitis C virus, susceptibility to
- KRT8 p.Ile183Asn Uncertain significance Single submitter
- KRT8 p.Leu147Val Uncertain significance Single submitter
- KRT8 p.Leu159Met Uncertain significance Single submitter
- KRT8 p.Leu344Val Uncertain significance Single submitter
- KRT8 p.Leu430Ile Uncertain significance Single submitter
- KRT8 p.Leu73Arg Uncertain significance Single submitter
- KRT8 p.Met367Ile Uncertain significance Single submitter
- KRT8 p.Pro17Ser Uncertain significance Single submitter
- KRT8 p.Ser243Phe Uncertain significance Single submitter
- KRT8 p.Ser24Phe Uncertain significance Single submitter
- KRT8 p.Ser9Ala Uncertain significance Single submitter
- KRT8 p.Thr468Lys Uncertain significance Single submitter
- KRT8 p.Tyr54Cys Uncertain significance Single submitter
- KRT8 p.Val200Met Uncertain significance Single submitter
- KRT8 p.Val245Met Uncertain significance Single submitter
Predictors split 13
The independent predictors disagree with each other — read with care.
- KRT8 p.Gly62Cys Benign/Likely benign Multiple submitters
-
KRT8 p.Ile63Val
Benign/Likely benign
Multiple submitters
inflammatory bowel disease
- KRT8 p.Lys464Asn Uncertain significance Multiple submitters
-
KRT8 p.Tyr54His
Benign/Likely benign
Multiple submitters
hepatitis C virus, susceptibility to
- KRT8 p.Arg40Gln Uncertain significance Single submitter
- KRT8 p.Gly422Val Uncertain significance Single submitter
- KRT8 p.Met310Ile Uncertain significance Single submitter
- KRT8 p.Ser247Ala Uncertain significance Single submitter
- KRT8 p.Ser425Leu Uncertain significance Single submitter
- KRT8 p.Ser445Cys Uncertain significance Single submitter
- KRT8 p.Ser58Asn Uncertain significance Single submitter
- KRT8 p.Thr131Met Uncertain significance Single submitter
- KRT8 p.Val380Ile Likely benign Single submitter
All KRT8 variants
Benign 8
- c.-4T>C Multiple submitters
- p.Ala333= Multiple submitters
- p.Arg341His Multiple submitters
- p.Gly434Ser Multiple submitters
- c.1261+9C>T Single submitter
- c.39-2208G>A Single submitter
- p.Val480Ile Single submitter
- c.-10T>A No assertion criteria KRT8-related disorder
Benign/Likely benign 3
- p.Gly62Cys Multiple submitters ⚠
- p.Ile63Val Multiple submitters inflammatory bowel disease ⚠
- p.Tyr54His Multiple submitters hepatitis C virus, susceptibility to ⚠
Likely benign 17
- c.1203-8G>T Single submitter
- c.595-9A>C Single submitter
- c.981+9C>G Single submitter
- p.Ala447Val Single submitter hepatitis C virus, susceptibility to
- p.Asn379= Single submitter
- p.Leu435= Single submitter
- p.Leu435Phe Single submitter
- p.Phe452= Single submitter
- p.Pro29= Single submitter
- p.Ser258Gly Single submitter
- p.Thr455= Single submitter
- p.Val380Ile Single submitter ⚠
- c.-29G>A No assertion criteria KRT8-related disorder
- p.Ala319Ser No assertion criteria KRT8-related disorder
- p.Ala338= No assertion criteria KRT8-related disorder
- p.Asn191= No assertion criteria KRT8-related disorder
- p.Lys122Thr No assertion criteria EBV-positive nodal T- and NK-cell lymphoma
Uncertain significance 53
- p.Lys464Asn Multiple submitters ⚠
- p.Ala334Thr Single submitter ⚠
- p.Ala351Thr Single submitter ⚠
- p.Ala86Val Single submitter ⚠
- p.Arg149Trp Single submitter ⚠
- p.Arg186Gly Single submitter ⚠
- p.Arg273Cys Single submitter
- p.Arg275Gln Single submitter ⚠
- p.Arg302His Single submitter ⚠
- p.Arg316Trp Single submitter ⚠
- p.Arg32Pro Single submitter
- p.Arg362Gln Single submitter ⚠
- p.Arg369Trp Single submitter
- p.Arg372Cys Single submitter ⚠
- p.Arg372His Single submitter ⚠
- p.Arg392Gly Single submitter ⚠
- p.Arg40Gln Single submitter ⚠
- p.Arg454Leu Single submitter ⚠
- p.Asn191Ser Single submitter ⚠
- p.Asn222Lys Single submitter ⚠
- p.Asp255His Single submitter ⚠
- p.Asp479Glu Single submitter ⚠
- p.Gln283His Single submitter
- p.Gln7Pro Single submitter ⚠
- p.Glu209Lys Single submitter ⚠
- p.Glu339Lys Single submitter ⚠
- p.Gly422Val Single submitter ⚠
- p.Gly429Ser Single submitter ⚠
- p.Gly444Ser Single submitter ⚠
- p.Gly471Glu Single submitter hepatitis C virus, susceptibility to ⚠
- p.Ile183Asn Single submitter ⚠
- p.Leu147Val Single submitter ⚠
- p.Leu159Met Single submitter ⚠
- p.Leu344Val Single submitter ⚠
- p.Leu430Ile Single submitter ⚠
- p.Leu73Arg Single submitter ⚠
- p.Met310Ile Single submitter ⚠
- p.Met367Ile Single submitter ⚠
- p.Pro17Ser Single submitter ⚠
- p.Ser243Phe Single submitter ⚠
- p.Ser247Ala Single submitter ⚠
- p.Ser24Phe Single submitter ⚠
- p.Ser425Leu Single submitter ⚠
- p.Ser445Cys Single submitter ⚠
- p.Ser58Asn Single submitter ⚠
- p.Ser9Ala Single submitter ⚠
- p.Thr131Met Single submitter ⚠
- p.Thr468Lys Single submitter ⚠
- p.Tyr228Cys Single submitter
- p.Tyr54Cys Single submitter ⚠
- p.Val200Met Single submitter ⚠
- p.Val245Met Single submitter ⚠
- c.1202+1G>A No assertion criteria