LAMTOR3 — 17 ClinVar variants
All ClinVar germline LAMTOR3 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 14 flagged for review →
17 Uncertain significance
Full LAMTOR3 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 14
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 9
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- LAMTOR3 p.Arg85His Uncertain significance Single submitter
- LAMTOR3 p.Asn39Ser Uncertain significance Single submitter
- LAMTOR3 p.Glu109Lys Uncertain significance Single submitter
- LAMTOR3 p.Phe83Leu Uncertain significance Single submitter
- LAMTOR3 p.Ser105Gly Uncertain significance Single submitter
- LAMTOR3 p.Ser51Tyr Uncertain significance Single submitter
- LAMTOR3 p.Ser96Asn Uncertain significance Single submitter
- LAMTOR3 p.Tyr10Cys Uncertain significance Single submitter
- LAMTOR3 p.Tyr74Asn Uncertain significance Single submitter
Predictors split 5
The independent predictors disagree with each other — read with care.
All LAMTOR3 variants
Uncertain significance 17
- p.Ala21Gly Single submitter
- p.Arg46Gln Single submitter ⚠
- p.Arg85His Single submitter ⚠
- p.Asn39Ser Single submitter ⚠
- p.Glu109Lys Single submitter ⚠
- p.His43Gln Single submitter ⚠
- p.Ile72Met Single submitter
- p.Ile93Leu Single submitter
- p.Phe83Leu Single submitter ⚠
- p.Pro31Ala Single submitter ⚠
- p.Ser105Gly Single submitter ⚠
- p.Ser51Tyr Single submitter ⚠
- p.Ser96Asn Single submitter ⚠
- p.Ser97Arg Single submitter ⚠
- p.Tyr10Cys Single submitter ⚠
- p.Tyr74Asn Single submitter ⚠
- p.Val121Leu Single submitter ⚠