LANCL2 — 69 ClinVar variants
All ClinVar germline LANCL2 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 62 flagged for review →
1 Benign · 3 Likely benign · 65 Uncertain significance
Full LANCL2 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 62
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 48
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- LANCL2 p.Ala277Val Uncertain significance Single submitter
- LANCL2 p.Ala334Val Uncertain significance Single submitter
- LANCL2 p.Ala37Glu Uncertain significance Single submitter
- LANCL2 p.Ala424Thr Uncertain significance Single submitter
- LANCL2 p.Ala44Val Uncertain significance Single submitter
- LANCL2 p.Arg128Gln Uncertain significance Single submitter
- LANCL2 p.Arg200Trp Uncertain significance Single submitter
- LANCL2 p.Arg297Cys Uncertain significance Single submitter
- LANCL2 p.Arg297His Uncertain significance Single submitter
- LANCL2 p.Arg302Gln Uncertain significance Single submitter
- LANCL2 p.Arg361Trp Uncertain significance Single submitter
- LANCL2 p.Arg438Gln Uncertain significance Single submitter
- LANCL2 p.Arg438Trp Uncertain significance Single submitter
- LANCL2 p.Asn312Ser Uncertain significance Single submitter
- LANCL2 p.Asp131Tyr Uncertain significance Single submitter
- LANCL2 p.Cys100Ser Uncertain significance Single submitter
- LANCL2 p.Glu283Lys Uncertain significance Single submitter
- LANCL2 p.Gly202Ala Uncertain significance Single submitter
- LANCL2 p.Gly261Ala Uncertain significance Single submitter
- LANCL2 p.Gly365Arg Uncertain significance Single submitter
- LANCL2 p.Gly407Arg Uncertain significance Single submitter
- LANCL2 p.Gly423Asp Uncertain significance Single submitter
- LANCL2 p.Gly60Ser Uncertain significance Single submitter
- LANCL2 p.His64Arg Uncertain significance Single submitter
- LANCL2 p.His64Gln Uncertain significance Single submitter
- LANCL2 p.His64Tyr Uncertain significance Single submitter
- LANCL2 p.Ile74Met Uncertain significance Single submitter
- LANCL2 p.Ile81Met Uncertain significance Single submitter
- LANCL2 p.Leu11His Uncertain significance Single submitter
- LANCL2 p.Leu197His Uncertain significance Single submitter
- LANCL2 p.Leu197Phe Uncertain significance Single submitter
- LANCL2 p.Leu331Phe Uncertain significance Single submitter
- LANCL2 p.Leu38Val Uncertain significance Single submitter
- LANCL2 p.Lys336Glu Uncertain significance Single submitter
- LANCL2 p.Met274Arg Uncertain significance Single submitter
- LANCL2 p.Pro154Arg Uncertain significance Single submitter
- LANCL2 p.Pro249Leu Uncertain significance Single submitter
- LANCL2 p.Pro29Leu Uncertain significance Single submitter
- LANCL2 p.Pro53Thr Uncertain significance Single submitter
- LANCL2 p.Ser129Cys Uncertain significance Single submitter
- LANCL2 p.Ser41Phe Uncertain significance Single submitter
- LANCL2 p.Thr124Ser Uncertain significance Single submitter
- LANCL2 p.Thr4Ile Uncertain significance Single submitter
- LANCL2 p.Thr55Pro Uncertain significance Single submitter
- LANCL2 p.Tyr31Cys Uncertain significance Single submitter
- LANCL2 p.Val133Ile Uncertain significance Single submitter
- LANCL2 p.Val145Phe Uncertain significance Single submitter
- LANCL2 p.Val280Ala Uncertain significance Single submitter
Predictors split 14
The independent predictors disagree with each other — read with care.
- LANCL2 p.Ala35Pro Uncertain significance Single submitter
- LANCL2 p.Arg183Ile Uncertain significance Single submitter
- LANCL2 p.Arg392Gln Uncertain significance Single submitter
- LANCL2 p.Arg8Ser Uncertain significance Single submitter
- LANCL2 p.Glu32Lys Uncertain significance Single submitter
- LANCL2 p.Glu3Lys Uncertain significance Single submitter
- LANCL2 p.Gly67Arg Uncertain significance Single submitter
- LANCL2 p.Leu238Ser Uncertain significance Single submitter
- LANCL2 p.Leu390Phe Uncertain significance Single submitter
- LANCL2 p.Pro249Arg Uncertain significance Single submitter
- LANCL2 p.Pro434Leu Uncertain significance Single submitter
- LANCL2 p.Thr370Ile Uncertain significance Single submitter
- LANCL2 p.Thr384Met Uncertain significance Single submitter
- LANCL2 p.Val219Met Uncertain significance Single submitter
All LANCL2 variants
Benign 1
- p.Ser308= Single submitter
Likely benign 3
- p.Asn229Ser Single submitter
- p.Gln188Arg Single submitter
- p.Val50Ala Single submitter
Uncertain significance 65
- p.Ala277Val Single submitter ⚠
- p.Ala334Val Single submitter ⚠
- p.Ala35Pro Single submitter ⚠
- p.Ala37Glu Single submitter ⚠
- p.Ala424Thr Single submitter ⚠
- p.Ala44Val Single submitter ⚠
- p.Arg128Gln Single submitter ⚠
- p.Arg183Ile Single submitter ⚠
- p.Arg200Trp Single submitter ⚠
- p.Arg247Cys Single submitter
- p.Arg297Cys Single submitter ⚠
- p.Arg297His Single submitter ⚠
- p.Arg302Gln Single submitter ⚠
- p.Arg361Trp Single submitter ⚠
- p.Arg392Gln Single submitter ⚠
- p.Arg438Gln Single submitter ⚠
- p.Arg438Trp Single submitter ⚠
- p.Arg8Ser Single submitter ⚠
- p.Asn312Ser Single submitter ⚠
- p.Asp131Tyr Single submitter ⚠
- p.Cys100Ser Single submitter ⚠
- p.Glu283Lys Single submitter ⚠
- p.Glu32Lys Single submitter ⚠
- p.Glu3Lys Single submitter ⚠
- p.Gly202Ala Single submitter ⚠
- p.Gly261Ala Single submitter ⚠
- p.Gly365Arg Single submitter ⚠
- p.Gly374Ser Single submitter
- p.Gly407Arg Single submitter ⚠
- p.Gly423Asp Single submitter ⚠
- p.Gly60Ser Single submitter ⚠
- p.Gly67Arg Single submitter ⚠
- p.His64Arg Single submitter ⚠
- p.His64Gln Single submitter ⚠
- p.His64Tyr Single submitter ⚠
- p.Ile74Met Single submitter ⚠
- p.Ile81Met Single submitter ⚠
- p.Leu11His Single submitter ⚠
- p.Leu197His Single submitter ⚠
- p.Leu197Phe Single submitter ⚠
- p.Leu238Ser Single submitter ⚠
- p.Leu331Phe Single submitter ⚠
- p.Leu38Val Single submitter ⚠
- p.Leu390Phe Single submitter ⚠
- p.Lys336Glu Single submitter ⚠
- p.Met274Arg Single submitter ⚠
- p.Pro154Arg Single submitter ⚠
- p.Pro249Arg Single submitter ⚠
- p.Pro249Leu Single submitter ⚠
- p.Pro29Leu Single submitter ⚠
- p.Pro434Leu Single submitter ⚠
- p.Pro53Thr Single submitter ⚠
- p.Ser129Cys Single submitter ⚠
- p.Ser41Phe Single submitter ⚠
- p.Thr124Ser Single submitter ⚠
- p.Thr370Ile Single submitter ⚠
- p.Thr384Met Single submitter ⚠
- p.Thr4Ile Single submitter ⚠
- p.Thr55Pro Single submitter ⚠
- p.Tyr31Cys Single submitter ⚠
- p.Val133Ile Single submitter ⚠
- p.Val145Phe Single submitter ⚠
- p.Val219Met Single submitter ⚠
- p.Val227Ala Single submitter
- p.Val280Ala Single submitter ⚠