LAP3 — 86 ClinVar variants
All ClinVar germline LAP3 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 79 flagged for review →
2 Likely benign · 84 Uncertain significance
Full LAP3 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 79
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 63
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- LAP3 p.Ala105Ser Uncertain significance Single submitter
- LAP3 p.Ala151Ser Uncertain significance Single submitter
- LAP3 p.Ala175Thr Uncertain significance Single submitter
- LAP3 p.Ala244Thr Uncertain significance Single submitter
- LAP3 p.Ala30Thr Uncertain significance Single submitter
- LAP3 p.Ala30Val Uncertain significance Single submitter
- LAP3 p.Ala404Asp Uncertain significance Single submitter
- LAP3 p.Ala461Glu Uncertain significance Single submitter
- LAP3 p.Ala483Glu Uncertain significance Single submitter
- LAP3 p.Arg15Gln Uncertain significance Single submitter
- LAP3 p.Arg15Gly Uncertain significance Single submitter
- LAP3 p.Arg20Ser Uncertain significance Single submitter
- LAP3 p.Arg21Cys Uncertain significance Single submitter
- LAP3 p.Arg428His Uncertain significance Single submitter
- LAP3 p.Arg496Trp Uncertain significance Single submitter
- LAP3 p.Asn113Thr Uncertain significance Single submitter
- LAP3 p.Asn197Tyr Uncertain significance Single submitter
- LAP3 p.Asn382Thr Uncertain significance Single submitter
- LAP3 p.Asp109Asn Uncertain significance Single submitter
- LAP3 p.Asp134Tyr Uncertain significance Single submitter
- LAP3 p.Asp163Asn Uncertain significance Single submitter
- LAP3 p.Asp163Gly Uncertain significance Single submitter
- LAP3 p.Asp427Ala Uncertain significance Single submitter
- LAP3 p.Asp92Asn Uncertain significance Single submitter
- LAP3 p.Glu217Lys Uncertain significance Single submitter
- LAP3 p.Glu257Lys Uncertain significance Single submitter
- LAP3 p.Glu420Lys Uncertain significance Single submitter
- LAP3 p.Gly179Glu Uncertain significance Single submitter
- LAP3 p.Gly307Glu Uncertain significance Single submitter
- LAP3 p.Gly341Ser Uncertain significance Single submitter
- LAP3 p.Gly394Asp Uncertain significance Single submitter
- LAP3 p.Gly401Glu Uncertain significance Single submitter
- LAP3 p.Gly460Arg Uncertain significance Single submitter
- LAP3 p.Ile284Val Uncertain significance Single submitter
- LAP3 p.Ile40Thr Uncertain significance Single submitter
- LAP3 p.Ile73Met Uncertain significance Single submitter
- LAP3 p.Leu191Met Uncertain significance Single submitter
- LAP3 p.Leu387His Uncertain significance Single submitter
- LAP3 p.Leu4Met Uncertain significance Single submitter
- LAP3 p.Leu62Phe Uncertain significance Single submitter
- LAP3 p.Leu6Phe Uncertain significance Single submitter
- LAP3 p.Lys321Asn Uncertain significance Single submitter
- LAP3 p.Lys384Thr Uncertain significance Single submitter
- LAP3 p.Met299Thr Uncertain significance Single submitter
- LAP3 p.Met32Arg Uncertain significance Single submitter
- LAP3 p.Met396Ile Uncertain significance Single submitter
- LAP3 p.Met396Val Uncertain significance Single submitter
- LAP3 p.Phe215Ile Uncertain significance Single submitter
- LAP3 p.Phe471Leu Uncertain significance Single submitter
- LAP3 p.Pro475Ser Uncertain significance Single submitter
- LAP3 p.Ser138Leu Uncertain significance Single submitter
- LAP3 p.Ser174Leu Uncertain significance Single submitter
- LAP3 p.Ser228Asn Uncertain significance Single submitter
- LAP3 p.Ser54Asn Uncertain significance Single submitter
- LAP3 p.Thr83Ile Uncertain significance Single submitter
- LAP3 p.Trp415Cys Uncertain significance Single submitter
- LAP3 p.Trp415Ser Uncertain significance Single submitter
- LAP3 p.Tyr178Cys Uncertain significance Single submitter
- LAP3 p.Val19Leu Uncertain significance Single submitter
- LAP3 p.Val317Met Uncertain significance Single submitter
- LAP3 p.Val407Phe Uncertain significance Single submitter
- LAP3 p.Val472Ile Uncertain significance Single submitter
- LAP3 p.Val49Leu Uncertain significance Single submitter
Predictors split 16
The independent predictors disagree with each other — read with care.
- LAP3 p.Ala148Thr Uncertain significance Single submitter
- LAP3 p.Ala320Thr Uncertain significance Single submitter
- LAP3 p.Ala390Ser Uncertain significance Single submitter
- LAP3 p.Arg351Gly Uncertain significance Single submitter
- LAP3 p.Asn488Asp Uncertain significance Single submitter
- LAP3 p.Asp47Asn Uncertain significance Single submitter
- LAP3 p.Gly403Asp Uncertain significance Single submitter
- LAP3 p.His437Arg Uncertain significance Single submitter
- LAP3 p.Ile329Thr Uncertain significance Single submitter
- LAP3 p.Leu101Phe Uncertain significance Single submitter
- LAP3 p.Lys417Ile Uncertain significance Single submitter
- LAP3 p.Met486Leu Uncertain significance Single submitter
- LAP3 p.Ser227Gly Uncertain significance Single submitter
- LAP3 p.Ser515Asn Uncertain significance Single submitter
- LAP3 p.Tyr41Cys Uncertain significance Single submitter
- LAP3 p.Val485Met Uncertain significance Single submitter
All LAP3 variants
Likely benign 2
- p.Arg214Lys Single submitter
- p.Lys224Arg Single submitter
Uncertain significance 84
- p.Ala105Ser Single submitter ⚠
- p.Ala148Thr Single submitter ⚠
- p.Ala151Ser Single submitter ⚠
- p.Ala175Thr Single submitter ⚠
- p.Ala199Gly Single submitter
- p.Ala244Thr Single submitter ⚠
- p.Ala30Thr Single submitter ⚠
- p.Ala30Val Single submitter ⚠
- p.Ala320Thr Single submitter ⚠
- p.Ala390Ser Single submitter ⚠
- p.Ala404Asp Single submitter ⚠
- p.Ala461Glu Single submitter ⚠
- p.Ala483Glu Single submitter ⚠
- p.Arg15Gln Single submitter ⚠
- p.Arg15Gly Single submitter ⚠
- p.Arg20Ser Single submitter ⚠
- p.Arg21Cys Single submitter ⚠
- p.Arg351Gly Single submitter ⚠
- p.Arg428His Single submitter ⚠
- p.Arg496Trp Single submitter ⚠
- p.Asn113Thr Single submitter ⚠
- p.Asn197Tyr Single submitter ⚠
- p.Asn382Thr Single submitter ⚠
- p.Asn488Asp Single submitter ⚠
- p.Asp109Asn Single submitter ⚠
- p.Asp134Tyr Single submitter ⚠
- p.Asp163Asn Single submitter ⚠
- p.Asp163Gly Single submitter ⚠
- p.Asp427Ala Single submitter ⚠
- p.Asp47Asn Single submitter ⚠
- p.Asp92Asn Single submitter ⚠
- p.Gln133His Single submitter
- p.Glu217Lys Single submitter ⚠
- p.Glu257Lys Single submitter ⚠
- p.Glu420Lys Single submitter ⚠
- p.Glu509Asp Single submitter
- p.Gly179Glu Single submitter ⚠
- p.Gly246Arg Single submitter
- p.Gly307Glu Single submitter ⚠
- p.Gly341Ser Single submitter ⚠
- p.Gly394Asp Single submitter ⚠
- p.Gly401Glu Single submitter ⚠
- p.Gly403Asp Single submitter ⚠
- p.Gly460Arg Single submitter ⚠
- p.His437Arg Single submitter ⚠
- p.Ile284Val Single submitter ⚠
- p.Ile329Thr Single submitter ⚠
- p.Ile40Thr Single submitter ⚠
- p.Ile73Met Single submitter ⚠
- p.Leu101Phe Single submitter ⚠
- p.Leu191Met Single submitter ⚠
- p.Leu334Val Single submitter
- p.Leu387His Single submitter ⚠
- p.Leu4Met Single submitter ⚠
- p.Leu62Phe Single submitter ⚠
- p.Leu6Phe Single submitter ⚠
- p.Lys321Asn Single submitter ⚠
- p.Lys384Thr Single submitter ⚠
- p.Lys417Ile Single submitter ⚠
- p.Met299Thr Single submitter ⚠
- p.Met32Arg Single submitter ⚠
- p.Met396Ile Single submitter ⚠
- p.Met396Val Single submitter ⚠
- p.Met486Leu Single submitter ⚠
- p.Phe215Ile Single submitter ⚠
- p.Phe471Leu Single submitter ⚠
- p.Pro475Ser Single submitter ⚠
- p.Ser138Leu Single submitter ⚠
- p.Ser174Leu Single submitter ⚠
- p.Ser227Gly Single submitter ⚠
- p.Ser228Asn Single submitter ⚠
- p.Ser515Asn Single submitter ⚠
- p.Ser54Asn Single submitter ⚠
- p.Thr83Ile Single submitter ⚠
- p.Trp415Cys Single submitter ⚠
- p.Trp415Ser Single submitter ⚠
- p.Tyr178Cys Single submitter ⚠
- p.Tyr41Cys Single submitter ⚠
- p.Val19Leu Single submitter ⚠
- p.Val317Met Single submitter ⚠
- p.Val407Phe Single submitter ⚠
- p.Val472Ile Single submitter ⚠
- p.Val485Met Single submitter ⚠
- p.Val49Leu Single submitter ⚠