Sugi Variant

Sugi Variant/LARS2

LARS2 — 620 ClinVar variants

All ClinVar germline LARS2 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 234 flagged for review →

27 Pathogenic · 10 Pathogenic/Likely pathogenic · 29 Likely pathogenic · 25 Conflicting · 58 Benign · 12 Benign/Likely benign · 241 Likely benign · 218 Uncertain significance

Full LARS2 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions

⚑ Evidence disagreements 234

Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.

Predictors vs ClinVar 11

ClinVar calls these pathogenic, but the computational predictors lean tolerated — the highest-value review flag.

Predictors agree, ClinVar conflicts 14

ClinVar submitters conflict, but the independent predictors unanimously agree — a QC review flag, not a reclassification.

Predictors lean, ClinVar uncertain 148

ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.

Predictors split 61

The independent predictors disagree with each other — read with care.

All LARS2 variants

Pathogenic 27

Pathogenic/Likely pathogenic 10

Likely pathogenic 29

Conflicting classifications of pathogenicity 25

Benign 58

Benign/Likely benign 12

Likely benign 241

Uncertain significance 218