LASP1 — 32 ClinVar variants
All ClinVar germline LASP1 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 25 flagged for review →
2 Benign · 2 Likely benign · 28 Uncertain significance
Full LASP1 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 25
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 20
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- LASP1 p.Ala102Val Uncertain significance Single submitter
- LASP1 p.Ala199Thr Uncertain significance Single submitter
- LASP1 p.Arg130His Uncertain significance Single submitter
- LASP1 p.Arg154Gln Uncertain significance Single submitter
- LASP1 p.Arg197Cys Uncertain significance Single submitter
- LASP1 p.Arg7Gln Uncertain significance Single submitter
- LASP1 p.Asp145Val Uncertain significance Single submitter
- LASP1 p.Glu106Lys Uncertain significance Single submitter
- LASP1 p.Gly201Ser Uncertain significance Single submitter
- LASP1 p.Gly202Arg Uncertain significance Single submitter
- LASP1 p.Ile195Thr Uncertain significance Single submitter
- LASP1 p.Lys111Arg Uncertain significance Single submitter
- LASP1 p.Met131Val Uncertain significance Single submitter
- LASP1 p.Met139Val Uncertain significance Single submitter
- LASP1 p.Pro161Leu Uncertain significance Single submitter
- LASP1 p.Pro200Ser Uncertain significance Single submitter
-
LASP1 p.Pro69Leu
Uncertain significance
Single submitter
hereditary breast ovarian cancer syndrome
- LASP1 p.Ser150Gly Uncertain significance Single submitter
- LASP1 p.Tyr152Asn Uncertain significance Single submitter
- LASP1 p.Tyr207Cys Uncertain significance Single submitter
Predictors split 5
The independent predictors disagree with each other — read with care.
All LASP1 variants
Likely benign 2
- p.Pro165= Single submitter
- p.Val230Ile Single submitter
Uncertain significance 28
- p.Ala102Val Single submitter ⚠
- p.Ala199Thr Single submitter ⚠
- p.Ala216Thr Single submitter ⚠
- p.Arg130His Single submitter ⚠
- p.Arg154Gln Single submitter ⚠
- p.Arg154Trp Single submitter ⚠
- p.Arg197Cys Single submitter ⚠
- p.Arg7Gln Single submitter ⚠
- p.Asp145Val Single submitter ⚠
- p.Asp237Asn Single submitter
- p.Glu106Lys Single submitter ⚠
- p.Gly201Ser Single submitter ⚠
- p.Gly202Arg Single submitter ⚠
- p.Gly204Arg Single submitter ⚠
- p.Ile195Thr Single submitter ⚠
- p.Lys111Arg Single submitter ⚠
- p.Met131Val Single submitter ⚠
- p.Met139Val Single submitter ⚠
- p.Pro161Leu Single submitter ⚠
- p.Pro165Leu Single submitter ⚠
- p.Pro200Ser Single submitter ⚠
- p.Pro69Leu Single submitter hereditary breast ovarian cancer syndrome ⚠
- p.Ser150Gly Single submitter ⚠
- p.Thr243Met Single submitter
- p.Thr243Ser Single submitter ⚠
- p.Thr38Ser Single submitter
- p.Tyr152Asn Single submitter ⚠
- p.Tyr207Cys Single submitter ⚠