LATS2 — 159 ClinVar variants

All ClinVar germline LATS2 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 126 flagged for review →

1 Likely pathogenic · 13 Benign · 1 Benign/Likely benign · 11 Likely benign · 133 Uncertain significance

Full LATS2 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions

⚑ Evidence disagreements 126

Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.

Predictors lean, ClinVar uncertain 107

ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.

Predictors split 19

The independent predictors disagree with each other — read with care.

All LATS2 variants

Likely pathogenic 1

p.Val901fs No assertion criteria malignant peritoneal mesothelioma

Benign 13

c.2665+5A>G Multiple submitters
p.Asp1013Asn Multiple submitters
p.Asp534= Multiple submitters
p.Asp852Glu Multiple submitters
p.Gly563Arg Multiple submitters
p.Leu386= Multiple submitters
p.Pro280= Multiple submitters
p.Pro519= Multiple submitters
p.Ser822= Multiple submitters
p.Thr431= Multiple submitters
p.467PA[8] Single submitter
p.Arg887= Single submitter
p.Ser974= Single submitter

Benign/Likely benign 1

p.Arg378= Multiple submitters

Likely benign 11

p.Ala1066Ser Single submitter
p.Ala472= Single submitter
p.Ala975Thr Single submitter
p.Asn549Ser Single submitter
p.Asn930Ser Single submitter
p.Gln1079= Single submitter
p.His1035= Single submitter
p.Leu186Met Single submitter
p.Leu705= Single submitter
p.Thr165Ala Single submitter
p.Thr202Ala Single submitter

Uncertain significance 133

p.Ala1021Thr Single submitter ⚠
p.Ala1036Glu Single submitter ⚠
p.Ala181Val Single submitter ⚠
p.Ala39Thr Single submitter ⚠
p.Ala428Asp Single submitter ⚠
p.Ala438Thr Single submitter ⚠
p.Ala464Thr Single submitter ⚠
p.Ala468Glu Single submitter ⚠
p.Ala470Ser Single submitter ⚠
p.Ala493Ser Single submitter ⚠
p.Ala768Thr Single submitter
p.Arg1054Gln Single submitter ⚠
p.Arg255Gln Single submitter ⚠
p.Arg271Cys Single submitter
p.Arg377Pro Single submitter ⚠
p.Arg391Gly Single submitter ⚠
p.Arg448Leu Single submitter ⚠
p.Arg558Cys Single submitter ⚠
p.Arg558Leu Single submitter ⚠
p.Arg590Lys Single submitter ⚠
p.Arg593His Single submitter ⚠
p.Arg849Gln Single submitter ⚠
p.Arg849Trp Single submitter ⚠
p.Arg887Cys Single submitter ⚠
p.Arg887His Single submitter ⚠
p.Asn1029Tyr Single submitter ⚠
p.Asn656Asp Single submitter ⚠
p.Asn821Lys Single submitter ⚠
p.Asn847His Single submitter ⚠
p.Asp341Asn Single submitter ⚠
p.Asp56Gly Single submitter ⚠
p.Asp56Val Single submitter ⚠
p.Cys513Tyr Single submitter ⚠
p.Cys537Arg Single submitter ⚠
p.Cys686Trp Single submitter
p.Gln1084His Single submitter ⚠
p.Gln148Lys Single submitter ⚠
p.Gln249His Single submitter ⚠
p.Gln74Glu Single submitter ⚠
p.Gln833Arg Single submitter ⚠
p.Gln985Leu Single submitter ⚠
p.Glu1034Gly Single submitter
p.Glu206Ala Single submitter ⚠
p.Glu24Asp Single submitter ⚠
p.Glu588Ala Single submitter
p.Gly1060Glu Single submitter ⚠
p.Gly188Ser Single submitter ⚠
p.Gly193Ser Single submitter ⚠
p.Gly197Ser Single submitter ⚠
p.Gly200Cys Single submitter ⚠
p.Gly218Arg Single submitter ⚠
p.Gly250Cys Single submitter ⚠
p.Gly268Arg Single submitter ⚠
p.Gly296Glu Single submitter ⚠
p.Gly299Ser Single submitter ⚠
p.Gly310Arg Single submitter ⚠
p.Gly310Glu Single submitter ⚠
p.Gly385Ser Single submitter ⚠
p.Gly420Val Single submitter ⚠
p.Gly498Arg Single submitter ⚠
p.Gly508Arg Single submitter ⚠
p.Gly539Ser Single submitter ⚠
p.Gly547Val Single submitter ⚠
p.Gly566Val Single submitter ⚠
p.Gly71Arg Single submitter ⚠
p.His257Pro Single submitter ⚠
p.His315Tyr Single submitter ⚠
p.His326Gln Single submitter ⚠
p.His442Tyr Single submitter ⚠
p.His691Gln Single submitter ⚠
p.His691Pro Single submitter ⚠
p.His789Asn Single submitter ⚠
p.Ile772Val Single submitter ⚠
p.Ile976Val Single submitter ⚠
p.Leu523Pro Single submitter ⚠
p.Leu536Pro Single submitter ⚠
p.Lys556Asn Single submitter ⚠
p.Lys568Arg Single submitter ⚠
p.Met667Val Single submitter ⚠
p.Met997Val Single submitter ⚠
p.Phe304Leu Single submitter ⚠
p.Phe304Ser Single submitter ⚠
p.Pro1010Leu Single submitter ⚠
p.Pro1010Ser Single submitter ⚠
p.Pro1033Ser Single submitter ⚠
p.Pro221Leu Single submitter ⚠
p.Pro221Ser Single submitter ⚠
p.Pro247Leu Single submitter ⚠
p.Pro247Ser Single submitter ⚠
p.Pro256Leu Single submitter ⚠
p.Pro273Ser Single submitter ⚠
p.Pro297Arg Single submitter ⚠
p.Pro307Ser Single submitter ⚠
p.Pro314Gln Single submitter ⚠
p.Pro316Ala Single submitter ⚠
p.Pro384Leu Single submitter ⚠
p.Pro38Ser Single submitter ⚠
p.Pro398Leu Single submitter ⚠
p.Pro429His Single submitter ⚠
p.Pro469Ser Single submitter ⚠
p.Pro479Leu Single submitter ⚠
p.Pro509Ser Single submitter ⚠
p.Pro514Ser Single submitter ⚠
p.Pro516Ala Single submitter
p.Pro517Ser Single submitter ⚠
p.Pro519Ser Single submitter ⚠
p.Pro68Ser Single submitter ⚠
p.Pro764Thr Single submitter ⚠
p.Pro916Ser Single submitter ⚠
p.Pro971Ser Single submitter ⚠
p.Ser1074Cys Single submitter ⚠
p.Ser195Gly Single submitter ⚠
p.Ser380Pro Single submitter ⚠
p.Ser461Leu Single submitter ⚠
p.Ser543Thr Single submitter ⚠
p.Ser557Gly Single submitter ⚠
p.Ser584Thr Single submitter ⚠
p.Ser846Pro Single submitter ⚠
p.Ser91Leu Single submitter ⚠
p.Ser979Phe Single submitter ⚠
p.Thr1019Ser Single submitter ⚠
p.Thr433Met Single submitter
p.Thr436Met Single submitter ⚠
p.Thr931Met Single submitter ⚠
p.Thr949Ile Single submitter ⚠
p.Thr992Asn Single submitter ⚠
p.Thr9Ala Single submitter ⚠
p.Tyr214Cys Single submitter ⚠
p.Tyr214His Single submitter ⚠
p.Val219Ala Single submitter ⚠
p.Val394Leu Single submitter ⚠
p.Val444Leu Single submitter ⚠
p.Val990Ile Single submitter ⚠