LCP1 — 58 ClinVar variants
All ClinVar germline LCP1 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 54 flagged for review →
1 Pathogenic · 3 Benign · 1 Likely benign · 53 Uncertain significance
Full LCP1 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 54
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 30
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- LCP1 p.Ala247Val Uncertain significance Single submitter
- LCP1 p.Ala341Val Uncertain significance Single submitter
- LCP1 p.Arg141Gln Uncertain significance Single submitter
- LCP1 p.Arg347Trp Uncertain significance Single submitter
- LCP1 p.Asn149Asp Uncertain significance Single submitter
- LCP1 p.Asn32Ser Uncertain significance Single submitter
- LCP1 p.Asn440Ser Uncertain significance Single submitter
- LCP1 p.Asn517Ser Uncertain significance Single submitter
- LCP1 p.Asp311Asn Uncertain significance Single submitter
- LCP1 p.Cys346Ser Uncertain significance Single submitter
- LCP1 p.Gln65Arg Uncertain significance Single submitter
- LCP1 p.Gly80Ser Uncertain significance Single submitter
- LCP1 p.Ile559Val Uncertain significance Single submitter
- LCP1 p.Leu248Met Uncertain significance Single submitter
- LCP1 p.Leu580Pro Uncertain significance Single submitter
- LCP1 p.Lys297Glu Uncertain significance Single submitter
- LCP1 p.Lys533Arg Uncertain significance Single submitter
- LCP1 p.Lys545Arg Uncertain significance Single submitter
- LCP1 p.Lys545Asn Uncertain significance Single submitter
- LCP1 p.Met146Ile Uncertain significance Single submitter
- LCP1 p.Met322Val Uncertain significance Single submitter
- LCP1 p.Met613Thr Uncertain significance Single submitter
- LCP1 p.Pro375Thr Uncertain significance Single submitter
- LCP1 p.Pro601Ser Uncertain significance Single submitter
- LCP1 p.Ser119Ala Uncertain significance Single submitter
- LCP1 p.Thr614Ile Uncertain significance Single submitter
- LCP1 p.Thr84Ala Uncertain significance Single submitter
- LCP1 p.Val318Ile Uncertain significance Single submitter
- LCP1 p.Val597Leu Uncertain significance Single submitter
- LCP1 p.Val597Met Uncertain significance Single submitter
Predictors split 24
The independent predictors disagree with each other — read with care.
- LCP1 p.Ala389Thr Uncertain significance Single submitter
- LCP1 p.Ala59Val Uncertain significance Single submitter
- LCP1 p.Arg326Trp Uncertain significance Single submitter
- LCP1 p.Arg347Gln Uncertain significance Single submitter
- LCP1 p.Arg398Gln Uncertain significance Single submitter
- LCP1 p.Arg412Gln Uncertain significance Single submitter
- LCP1 p.Arg488His Uncertain significance Single submitter
- LCP1 p.Asp72Tyr Uncertain significance Single submitter
- LCP1 p.Asp8Asn Uncertain significance Single submitter
- LCP1 p.Cys336Arg Uncertain significance Single submitter
- LCP1 p.Ile167Val Uncertain significance Single submitter
- LCP1 p.Leu264Ile Uncertain significance Single submitter
- LCP1 p.Met262Thr Uncertain significance Single submitter
- LCP1 p.Met58Ile Uncertain significance Single submitter
- LCP1 p.Pro445Leu Uncertain significance Single submitter
- LCP1 p.Pro544Ala Benign Single submitter
- LCP1 p.Pro544Leu Uncertain significance Single submitter
- LCP1 p.Ser257Arg Uncertain significance Single submitter
- LCP1 p.Thr150Met Uncertain significance Single submitter
- LCP1 p.Thr394Ala Uncertain significance Single submitter
- LCP1 p.Thr548Ala Uncertain significance Single submitter
- LCP1 p.Val112Ile Uncertain significance Single submitter
- LCP1 p.Val350Ile Uncertain significance Single submitter
- LCP1 p.Val615Met Uncertain significance Single submitter
All LCP1 variants
Pathogenic 1
- p.Tyr374Ter Single submitter hereditary breast ovarian cancer syndrome
Benign 3
- p.Ala40Val Multiple submitters
- c.1502+9G>T Single submitter
- p.Pro544Ala Single submitter ⚠
Likely benign 1
- p.Gln65Lys Single submitter
Uncertain significance 53
- p.Ala247Val Single submitter ⚠
- p.Ala341Val Single submitter ⚠
- p.Ala389Thr Single submitter ⚠
- p.Ala59Val Single submitter ⚠
- p.Arg141Gln Single submitter ⚠
- p.Arg326Trp Single submitter ⚠
- p.Arg347Gln Single submitter ⚠
- p.Arg347Trp Single submitter ⚠
- p.Arg398Gln Single submitter ⚠
- p.Arg412Gln Single submitter ⚠
- p.Arg488His Single submitter ⚠
- p.Asn149Asp Single submitter ⚠
- p.Asn32Ser Single submitter ⚠
- p.Asn440Ser Single submitter ⚠
- p.Asn517Ser Single submitter ⚠
- p.Asp311Asn Single submitter ⚠
- p.Asp72Tyr Single submitter ⚠
- p.Asp8Asn Single submitter ⚠
- p.Cys336Arg Single submitter ⚠
- p.Cys346Ser Single submitter ⚠
- p.Gln65Arg Single submitter ⚠
- p.Gly80Ser Single submitter ⚠
- p.Ile167Val Single submitter ⚠
- p.Ile559Val Single submitter ⚠
- p.Leu248Met Single submitter ⚠
- p.Leu264Ile Single submitter ⚠
- p.Leu580Pro Single submitter ⚠
- p.Lys297Glu Single submitter ⚠
- p.Lys533Arg Single submitter ⚠
- p.Lys545Arg Single submitter ⚠
- p.Lys545Asn Single submitter ⚠
- p.Met146Ile Single submitter ⚠
- p.Met262Thr Single submitter ⚠
- p.Met322Val Single submitter ⚠
- p.Met58Ile Single submitter ⚠
- p.Met613Thr Single submitter ⚠
- p.Pro375Thr Single submitter ⚠
- p.Pro445Leu Single submitter ⚠
- p.Pro544Leu Single submitter ⚠
- p.Pro601Ser Single submitter ⚠
- p.Ser119Ala Single submitter ⚠
- p.Ser257Arg Single submitter ⚠
- p.Thr150Met Single submitter ⚠
- p.Thr394Ala Single submitter ⚠
- p.Thr548Ala Single submitter ⚠
- p.Thr614Ile Single submitter ⚠
- p.Thr84Ala Single submitter ⚠
- p.Val112Ile Single submitter ⚠
- p.Val318Ile Single submitter ⚠
- p.Val350Ile Single submitter ⚠
- p.Val597Leu Single submitter ⚠
- p.Val597Met Single submitter ⚠
- p.Val615Met Single submitter ⚠