LENG8 — 145 ClinVar variants
All ClinVar germline LENG8 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 124 flagged for review →
1 Conflicting · 5 Benign · 13 Likely benign · 126 Uncertain significance
Full LENG8 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 124
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors agree, ClinVar conflicts 1
ClinVar submitters conflict, but the independent predictors unanimously agree — a QC review flag, not a reclassification.
Predictors lean, ClinVar uncertain 109
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- LENG8 p.Ala133Thr Uncertain significance Single submitter
- LENG8 p.Ala156Val Uncertain significance Single submitter
- LENG8 p.Ala199Thr Uncertain significance Single submitter
- LENG8 p.Ala244Thr Uncertain significance Single submitter
- LENG8 p.Ala360Thr Uncertain significance Single submitter
- LENG8 p.Ala369Val Uncertain significance Single submitter
- LENG8 p.Ala372Val Uncertain significance Single submitter
- LENG8 p.Ala477Val Uncertain significance Single submitter
- LENG8 p.Ala496Val Uncertain significance Single submitter
- LENG8 p.Ala55Val Uncertain significance Single submitter
- LENG8 p.Ala652Thr Uncertain significance Single submitter
- LENG8 p.Ala664Val Uncertain significance Single submitter
- LENG8 p.Ala751Val Uncertain significance Single submitter
- LENG8 p.Ala768Thr Uncertain significance Single submitter
- LENG8 p.Ala78Ser Uncertain significance Single submitter
- LENG8 p.Arg299Cys Uncertain significance Single submitter
- LENG8 p.Arg337Gln Uncertain significance Single submitter
- LENG8 p.Arg345Gln Uncertain significance Single submitter
- LENG8 p.Arg392Gln Uncertain significance Single submitter
- LENG8 p.Arg394Trp Uncertain significance Single submitter
- LENG8 p.Arg420Cys Uncertain significance Single submitter
- LENG8 p.Arg420His Uncertain significance Single submitter
- LENG8 p.Arg433Cys Uncertain significance Single submitter
- LENG8 p.Arg479His Uncertain significance Single submitter
- LENG8 p.Arg505Gln Uncertain significance Single submitter
- LENG8 p.Arg512Gln Uncertain significance Single submitter
- LENG8 p.Arg512Trp Uncertain significance Single submitter
- LENG8 p.Arg522His Uncertain significance Single submitter
- LENG8 p.Arg523Cys Uncertain significance Single submitter
- LENG8 p.Arg607Trp Uncertain significance Single submitter
- LENG8 p.Arg688Gln Uncertain significance Single submitter
- LENG8 p.Arg688Gly Uncertain significance Single submitter
- LENG8 p.Arg688Leu Uncertain significance Single submitter
- LENG8 p.Arg770Gln Uncertain significance Single submitter
- LENG8 p.Arg9His Uncertain significance Single submitter
- LENG8 p.Asn171Ile Uncertain significance Single submitter
- LENG8 p.Asn64Ser Uncertain significance Single submitter
- LENG8 p.Cys554Phe Uncertain significance Single submitter
- LENG8 p.Cys584Trp Uncertain significance Single submitter
- LENG8 p.Cys584Tyr Uncertain significance Single submitter
- LENG8 p.Gln257Arg Uncertain significance Single submitter
- LENG8 p.Gln264Arg Uncertain significance Single submitter
- LENG8 p.Gln75Arg Uncertain significance Single submitter
- LENG8 p.Gln796Arg Uncertain significance Single submitter
- LENG8 p.Gln8Arg Uncertain significance Single submitter
- LENG8 p.Glu268Lys Uncertain significance Single submitter
- LENG8 p.Glu358Asp Uncertain significance Single submitter
- LENG8 p.Gly147Ser Uncertain significance Single submitter
- LENG8 p.Gly186Ala Uncertain significance Single submitter
- LENG8 p.Gly376Arg Uncertain significance Single submitter
- LENG8 p.Gly377Asp Uncertain significance Single submitter
- LENG8 p.Gly377Val Uncertain significance Single submitter
- LENG8 p.Gly383Arg Uncertain significance Single submitter
- LENG8 p.Gly388Arg Uncertain significance Single submitter
- LENG8 p.Gly389Cys Uncertain significance Single submitter
- LENG8 p.Gly391Ser Uncertain significance Single submitter
- LENG8 p.Gly465Ser Uncertain significance Single submitter
- LENG8 p.Gly467Val Uncertain significance Single submitter
- LENG8 p.Gly56Ser Uncertain significance Single submitter
- LENG8 p.Gly65Val Uncertain significance Single submitter
- LENG8 p.His720Gln Uncertain significance Single submitter
- LENG8 p.Leu140Met Uncertain significance Single submitter
- LENG8 p.Leu564Phe Uncertain significance Single submitter
- LENG8 p.Leu690Gln Uncertain significance Single submitter
- LENG8 p.Leu728Phe Uncertain significance Single submitter
- LENG8 p.Leu776Val Uncertain significance Single submitter
- LENG8 p.Lys738Arg Uncertain significance Single submitter
- LENG8 p.Met107Ile Uncertain significance Single submitter
- LENG8 p.Met107Thr Uncertain significance Single submitter
- LENG8 p.Met585Val Uncertain significance Single submitter
- LENG8 p.Pro167Leu Uncertain significance Single submitter
- LENG8 p.Pro172Ser Uncertain significance Single submitter
- LENG8 p.Pro172Thr Uncertain significance Single submitter
- LENG8 p.Pro185Ser Uncertain significance Single submitter
- LENG8 p.Pro198Leu Uncertain significance Single submitter
- LENG8 p.Pro212Ala Uncertain significance Single submitter
- LENG8 p.Pro212Arg Uncertain significance Single submitter
- LENG8 p.Pro215His Uncertain significance Single submitter
- LENG8 p.Pro215Ser Uncertain significance Single submitter
- LENG8 p.Pro265Ser Uncertain significance Single submitter
- LENG8 p.Pro32Leu Uncertain significance Single submitter
- LENG8 p.Pro365Ser Uncertain significance Single submitter
- LENG8 p.Pro385Ser Uncertain significance Single submitter
- LENG8 p.Pro458Leu Uncertain significance Single submitter
- LENG8 p.Pro460Ala Uncertain significance Single submitter
- LENG8 p.Pro783Leu Uncertain significance Single submitter
- LENG8 p.Ser163Leu Uncertain significance Single submitter
- LENG8 p.Ser170Leu Uncertain significance Single submitter
- LENG8 p.Ser181Gly Uncertain significance Single submitter
- LENG8 p.Ser249Gly Uncertain significance Single submitter
- LENG8 p.Ser336Asn Uncertain significance Single submitter
- LENG8 p.Ser371Leu Uncertain significance Single submitter
- LENG8 p.Ser413Pro Uncertain significance Single submitter
- LENG8 p.Ser52Thr Uncertain significance Single submitter
- LENG8 p.Ser535Arg Uncertain significance Single submitter
- LENG8 p.Ser725Thr Uncertain significance Single submitter
- LENG8 p.Thr187Pro Uncertain significance Single submitter
- LENG8 p.Thr246Asn Uncertain significance Single submitter
- LENG8 p.Thr31Met Uncertain significance Single submitter
- LENG8 p.Thr384Ala Uncertain significance Single submitter
- LENG8 p.Thr429Met Uncertain significance Single submitter
- LENG8 p.Thr620Met Uncertain significance Single submitter
- LENG8 p.Thr781Met Uncertain significance Single submitter
- LENG8 p.Tyr685Asn Uncertain significance Single submitter
- LENG8 p.Val406Ile Uncertain significance Single submitter
- LENG8 p.Val453Leu Uncertain significance Single submitter
- LENG8 p.Val586Ile Uncertain significance Single submitter
- LENG8 p.Val586Phe Uncertain significance Single submitter
- LENG8 p.Val739Leu Uncertain significance Single submitter
Predictors split 14
The independent predictors disagree with each other — read with care.
- LENG8 p.Ala2Val Uncertain significance Single submitter
- LENG8 p.Arg241Leu Uncertain significance Single submitter
- LENG8 p.Arg356Gln Uncertain significance Single submitter
- LENG8 p.Arg356Trp Uncertain significance Single submitter
- LENG8 p.Arg463Trp Uncertain significance Single submitter
- LENG8 p.Asp595Glu Uncertain significance Single submitter
- LENG8 p.Cys695Tyr Uncertain significance Single submitter
- LENG8 p.Glu766Lys Uncertain significance Single submitter
- LENG8 p.Gly233Asp Uncertain significance Single submitter
- LENG8 p.Gly709Asp Uncertain significance Single submitter
- LENG8 p.Lys355Asn Uncertain significance Single submitter
- LENG8 p.Phe407Leu Uncertain significance Single submitter
- LENG8 p.Pro242His Uncertain significance Single submitter
- LENG8 p.Pro722Ser Uncertain significance Single submitter
All LENG8 variants
Conflicting classifications of pathogenicity 1
- p.Glu211Lys Single submitter ⚠
Benign 5
- c.1732-9C>T No assertion criteria LENG8-related disorder
- p.Arg430Cys No assertion criteria LENG8-related disorder
- p.Gln85His No assertion criteria LENG8-related disorder
- p.Ile557Val No assertion criteria LENG8-related disorder
- p.Ile630= No assertion criteria LENG8-related disorder
Likely benign 13
- c.*438C>T Single submitter
- p.Ala486= Single submitter
- p.Gly57Ser Single submitter
- p.Thr384= Single submitter
- p.Ala597= No assertion criteria LENG8-related disorder
- p.Arg616= No assertion criteria LENG8-related disorder
- p.Gly464= No assertion criteria LENG8-related disorder
- p.His34= No assertion criteria LENG8-related disorder
- p.Leu325= No assertion criteria LENG8-related disorder
- p.Pro198= No assertion criteria LENG8-related disorder
- p.Pro341= No assertion criteria LENG8-related disorder
- p.Pro750= No assertion criteria LENG8-related disorder
- p.Thr645= No assertion criteria LENG8-related disorder
Uncertain significance 126
- p.Ala133Thr Single submitter ⚠
- p.Ala156Val Single submitter ⚠
- p.Ala199Thr Single submitter ⚠
- p.Ala244Thr Single submitter ⚠
- p.Ala2Val Single submitter ⚠
- p.Ala360Thr Single submitter ⚠
- p.Ala369Val Single submitter ⚠
- p.Ala372Val Single submitter ⚠
- p.Ala477Val Single submitter ⚠
- p.Ala496Val Single submitter ⚠
- p.Ala55Val Single submitter ⚠
- p.Ala652Thr Single submitter ⚠
- p.Ala664Val Single submitter ⚠
- p.Ala751Val Single submitter ⚠
- p.Ala768Thr Single submitter ⚠
- p.Ala78Ser Single submitter ⚠
- p.Arg241Leu Single submitter ⚠
- p.Arg299Cys Single submitter ⚠
- p.Arg337Gln Single submitter ⚠
- p.Arg345Gln Single submitter ⚠
- p.Arg356Gln Single submitter ⚠
- p.Arg356Trp Single submitter ⚠
- p.Arg392Gln Single submitter ⚠
- p.Arg394Trp Single submitter ⚠
- p.Arg420Cys Single submitter ⚠
- p.Arg420His Single submitter ⚠
- p.Arg433Cys Single submitter ⚠
- p.Arg463Trp Single submitter ⚠
- p.Arg479His Single submitter ⚠
- p.Arg505Gln Single submitter ⚠
- p.Arg512Gln Single submitter ⚠
- p.Arg512Trp Single submitter ⚠
- p.Arg522His Single submitter ⚠
- p.Arg523Cys Single submitter ⚠
- p.Arg607Trp Single submitter ⚠
- p.Arg688Gln Single submitter ⚠
- p.Arg688Gly Single submitter ⚠
- p.Arg688Leu Single submitter ⚠
- p.Arg770Gln Single submitter ⚠
- p.Arg9His Single submitter ⚠
- p.Asn171Ile Single submitter ⚠
- p.Asn64Ser Single submitter ⚠
- p.Asp595Glu Single submitter ⚠
- p.Cys554Phe Single submitter ⚠
- p.Cys584Trp Single submitter ⚠
- p.Cys584Tyr Single submitter ⚠
- p.Cys695Tyr Single submitter ⚠
- p.Gln257Arg Single submitter ⚠
- p.Gln264Arg Single submitter ⚠
- p.Gln75Arg Single submitter ⚠
- p.Gln796Arg Single submitter ⚠
- p.Gln8Arg Single submitter ⚠
- p.Glu268Lys Single submitter ⚠
- p.Glu358Asp Single submitter ⚠
- p.Glu766Lys Single submitter ⚠
- p.Gly147Ser Single submitter ⚠
- p.Gly186Ala Single submitter ⚠
- p.Gly233Asp Single submitter ⚠
- p.Gly376Arg Single submitter ⚠
- p.Gly377Asp Single submitter ⚠
- p.Gly377Val Single submitter ⚠
- p.Gly383Arg Single submitter ⚠
- p.Gly388Arg Single submitter ⚠
- p.Gly389Cys Single submitter ⚠
- p.Gly391Ser Single submitter ⚠
- p.Gly465Ser Single submitter ⚠
- p.Gly467Val Single submitter ⚠
- p.Gly56Ser Single submitter ⚠
- p.Gly657fs Single submitter
- p.Gly65Val Single submitter ⚠
- p.Gly709Asp Single submitter ⚠
- p.His720Gln Single submitter ⚠
- p.Leu140Met Single submitter ⚠
- p.Leu564Phe Single submitter ⚠
- p.Leu690Gln Single submitter ⚠
- p.Leu728Phe Single submitter ⚠
- p.Leu776Val Single submitter ⚠
- p.Lys355Asn Single submitter ⚠
- p.Lys738Arg Single submitter ⚠
- p.Met107Ile Single submitter ⚠
- p.Met107Thr Single submitter ⚠
- p.Met585Val Single submitter ⚠
- p.Phe243fs Single submitter
- p.Phe407Leu Single submitter ⚠
- p.Pro167Leu Single submitter ⚠
- p.Pro172Ser Single submitter ⚠
- p.Pro172Thr Single submitter ⚠
- p.Pro185Ser Single submitter ⚠
- p.Pro198Leu Single submitter ⚠
- p.Pro212Ala Single submitter ⚠
- p.Pro212Arg Single submitter ⚠
- p.Pro215His Single submitter ⚠
- p.Pro215Ser Single submitter ⚠
- p.Pro242His Single submitter ⚠
- p.Pro265Ser Single submitter ⚠
- p.Pro32Leu Single submitter ⚠
- p.Pro365Ser Single submitter ⚠
- p.Pro385Ser Single submitter ⚠
- p.Pro458Leu Single submitter ⚠
- p.Pro460Ala Single submitter ⚠
- p.Pro722Ser Single submitter ⚠
- p.Pro783Leu Single submitter ⚠
- p.Ser163Leu Single submitter ⚠
- p.Ser170Leu Single submitter ⚠
- p.Ser181Gly Single submitter ⚠
- p.Ser249Gly Single submitter ⚠
- p.Ser336Asn Single submitter ⚠
- p.Ser371Leu Single submitter ⚠
- p.Ser413Pro Single submitter ⚠
- p.Ser52Thr Single submitter ⚠
- p.Ser535Arg Single submitter ⚠
- p.Ser725Thr Single submitter ⚠
- p.Thr187Pro Single submitter ⚠
- p.Thr246Asn Single submitter ⚠
- p.Thr31Met Single submitter ⚠
- p.Thr384Ala Single submitter ⚠
- p.Thr429Met Single submitter ⚠
- p.Thr620Met Single submitter ⚠
- p.Thr781Met Single submitter ⚠
- p.Tyr685Asn Single submitter ⚠
- p.Tyr727Cys Single submitter
- p.Val406Ile Single submitter ⚠
- p.Val453Leu Single submitter ⚠
- p.Val586Ile Single submitter ⚠
- p.Val586Phe Single submitter ⚠
- p.Val739Leu Single submitter ⚠